GlobalRPh Renal Dosing Masterv6.6
Evidence addition

Crizotinib (XALKORI, adult NSCLC/IMT)

Local RX List renal extractBase record retrieved 2026-09-07See the evidence for this drug1 sources available - open source summaries, references and comparisons

XALKORI

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Renal guidance at a glance

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Rxlist source

GlobalRPh RX List - XALKORI

Product / population
Adult NSCLC or adult IMT only; XALKORI capsules/pellets. No pediatric numeric regimen imported.
Renal measure
Modified Cockcroft-Gault CrCl for adults, mL/min; pediatric Schwartz is not interchangeable.

RX mirror: this is not independent corroboration of its underlying label. Check dated-label and formulation limitations.

Renal dosing, restrictions and evidence limits

For adults with NSCLC or IMT, no renal dose change is recommended at CrCl 30-89 mL/min. With severe impairment (CrCl <30) not requiring dialysis, use the second dose-reduction level: 250 mg orally once daily. The renal section refers explicitly to the dose-reduction table. Dialysis is outside this recommendation. Pediatric ALCL/IMT and young-adult ALCL use different body-surface-area tables; the adult fixed dose must not be transferred to those populations. The source uses modified Cockcroft-Gault for adults and Schwartz for pediatric assessment.

Source revision: Source revision date not established in selected retrieval. | Retrieved: 2026-09-07. Retrieval date is not the revision date.

Source: https://globalrph.com/rx-list/xalkori-drug/

Scope: Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph. GlobalRPh v6.6.

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Source-first renal review

Evidence sources and renal implications

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GlobalRPh RX List

GlobalRPh RX List - XALKORI

Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.

Adult NSCLC or adult IMT only; XALKORI capsules/pellets. No pediatric numeric regimen imported.

Renal method: Modified Cockcroft-Gault CrCl for adults, mL/min; pediatric Schwartz is not interchangeable.
Retrieved: 2026-09-07

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Renal dosing and precautions

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New source summary - independent clinical review pending. Summaries of the identified label sections are included locally. Source import and numeric transcription checks are not independent two-reference validation. Do not treat this card as an approved institutional dosing protocol.

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Original content / product scopeGlobalRPh RX List - XALKORI
Exact product and population matter. This added page contains locally stored, source-specific clinical summaries. Historical handbook information, when present, is identified separately and may conflict with U.S. labeling. Confirm indication, population, kidney-function method, monitoring and the full prescribing information before applying a regimen.
Locally stored source content

Exact product and population

Product identity selected for the separately displayed source protocols below. Reference: https://globalrph.com/rx-list/xalkori-drug/

Exact product and population

Adult NSCLC or adult IMT only; XALKORI capsules/pellets. No pediatric numeric regimen imported.

RDM35-SCOPE-crizotinib-xalkori-adult · Source section: Selected source product scopeRenal section finder
Locally imported selected renal sections

GlobalRPh RX List renal information

Rxlist

GlobalRPh RX List - XALKORI

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GlobalRPh-hosted RX List · Adult NSCLC or adult IMT only; XALKORI capsules/pellets. No pediatric numeric regimen imported.

Renal method: Modified Cockcroft-Gault CrCl for adults, mL/min; pediatric Schwartz is not interchangeable.
Source date: Source revision date not established in selected retrieval.
Retrieved: 2026-09-07

Label mirror, not independent corroboration. This is selected locally stored RX List content. Full monograph import and current official-label review are not implied.
Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.

Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph.

Renal dosing, restrictions and evidence limits

For adults with NSCLC or IMT, no renal dose change is recommended at CrCl 30-89 mL/min. With severe impairment (CrCl <30) not requiring dialysis, use the second dose-reduction level: 250 mg orally once daily. The renal section refers explicitly to the dose-reduction table. Dialysis is outside this recommendation. Pediatric ALCL/IMT and young-adult ALCL use different body-surface-area tables; the adult fixed dose must not be transferred to those populations. The source uses modified Cockcroft-Gault for adults and Schwartz for pediatric assessment.

RDM35-rxlist-crizotinib-xalkori-adult-1aef141a80-C1 · Source locator: Dosage modification for severe renal impairment; Table 4; renal-impairment section.

Source identity and provenance
Source family
product_label_mirror
Source
https://globalrph.com/rx-list/xalkori-drug/
Retrieved
2026-09-07
Renal-function method
Modified Cockcroft-Gault CrCl for adults, mL/min; pediatric Schwartz is not interchangeable.
Source date/version
Source revision date not established in selected retrieval.
Hash meaning
SHA-256 of local authored summary only; not original HTML, PDF or SPL bytes.
Local summary SHA-256
df334aeb8e1cb7753875e62f318125e462e94c26560345baf1707a63155cb177

Provenance and preservation

Additional summaries stored on this page: 0 official-label, 1 RX List, 0 professional, 0 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source
https://globalrph.com/rx-list/xalkori-drug/
Source retrieval
2026-09-07. This is not the source publication or label revision date.
Original source type
rxlist summary
Local text SHA-256
c2bbcc1abb86eaf7e84b36b36f5de82e62e82f2f4e3476392ac0d08eb442dfe3
Import versus clinical validation
Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

This page is an additional exact-product entry, not a recovered GlobalRPh monograph. Its primary scope text and separately attributed clinical summaries are locally included.

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