Colistimethate (Colistin) | GlobalRPh Renal Dosing Master

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Historical source

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Historical source: not automatically current. Review current official labeling and separately attributed additions before use.

All dose quantities on this source refer to colistin base activity, not milligrams of colistimethate salt or international units. Historical table and summary contain inconsistencies; they are preserved, not converted into a unified dosing calculator. The original hemodialysis section supplies no regimen.

Usual Dosing (Adults)

Colistimethate sodium injection: vials equivalent to 150 mg colistin base activity (CBA). Reconstitute each vial with 2 mL sterile water for injection, giving 75 mg/mL CBA. Swirl gently to avoid frothing; inspect for particles or discoloration and do not use affected product.

Adults and pediatric patients, IV or IM: 2.5 to 5 mg/kg/day in 2 to 4 divided doses with normal renal function, depending on infection severity. In obesity base dosage on ideal body weight. Reduce daily dosage in renal impairment.

Renal Dosing

The source note says: suggested unit dose 2.5 to 5 mg/kg, but increase the interval between injections in impaired renal function. This wording differs from the daily-dose introduction.

Source Table 1 for adults:

Measure	Normal	Mild	Moderate	Considerable impairment
Plasma creatinine, mg/100 mL	0.7 to 1.2	1.3 to 1.5	1.6 to 2.5	2.6 to 4.0
Urea clearance, % normal	80 to 100	40 to 70	25 to 40	10 to 25
Unit dose, mg	100 to 150	75 to 115	66 to 150	100 to 150
Frequency	4 to 2 times/day	Twice/day	Twice or once/day	Every 36 hours
Total daily dose, mg	300	150 to 230	133 to 150	100
Approximate daily dose, mg/kg/day	5	2.5 to 3.8	2.5	1.5

The source's separate summary reads: normal, 2.5 to 5 mg/kg/day in 2 to 4 doses; mild, 2.5 to 3.8 mg/kg/day in 2 doses; moderate, 1.6 to 2.5 mg/kg/day in 1 to 2 doses; considerable, approximately 1.5 mg/kg every 36 hours.

Hemodialysis

See package insert.

Source revision: Historical source; revision not established here | Retrieved: 2026-09-05. Retrieval date is not the revision date.

Source: https://globalrph.com/renal/colistimethate-colistin/

Scope: Preserved historical source; no fresh clinical approval GlobalRPh v6.6.

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Retrieved: 2026-09-05

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Locally stored source content

Original GlobalRPh protocol

Clinical facts and comments transcribed into a structured reading format. This is not a byte-for-byte HTML archive. Original source: https://globalrph.com/renal/colistimethate-colistin/

Usual Dosing (Adults)

GRPH-colistimethate-colistin-01 · Source section: Usual Dosing (Adults)Renal section finder

Renal Dosing

The source note says: suggested unit dose 2.5 to 5 mg/kg, but increase the interval between injections in impaired renal function. This wording differs from the daily-dose introduction.

Source Table 1 for adults:

Measure	Normal	Mild	Moderate	Considerable impairment
Plasma creatinine, mg/100 mL	0.7 to 1.2	1.3 to 1.5	1.6 to 2.5	2.6 to 4.0
Urea clearance, % normal	80 to 100	40 to 70	25 to 40	10 to 25
Unit dose, mg	100 to 150	75 to 115	66 to 150	100 to 150
Frequency	4 to 2 times/day	Twice/day	Twice or once/day	Every 36 hours
Total daily dose, mg	300	150 to 230	133 to 150	100
Approximate daily dose, mg/kg/day	5	2.5 to 3.8	2.5	1.5

GRPH-colistimethate-colistin-02 · Source section: Renal DosingRenal section finder

Hemodialysis

See package insert.

GRPH-colistimethate-colistin-03 · Source section: HemodialysisRenal section finder

Provenance and preservation

Additional summaries stored on this page: 0 official-label, 0 RX List, 0 professional, 0 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source: https://globalrph.com/renal/colistimethate-colistin/
Source retrieval: 2026-09-05. This is not the source publication or label revision date.
Original source type: globalrph individual
Local text SHA-256: 887fd96d9ef7b06d72ef488e7f07ec071f4c4ac2c75df10e7b5478e4388b2470
Import versus clinical validation: Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

The original individual GlobalRPh pages commonly cite NIH/NLM DailyMed and instruct readers to review the applicable package insert for updates. That historical reference is preserved as context; it is not counted as an independently retrieved current label.

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