GlobalRPh Renal Dosing Masterv6.8
Product-specific reference

Clofarabine IV injection (Clolar)

Local official-label summarySource retrieved 2026-10-02See the evidence for this drug2 sources available - open source summaries, references and comparisons

clofarabine / Clolar

READ THE SOURCE-SPECIFIC ANSWER

Renal guidance at a glance

Cautions / source differences (1)
Review first - source-specific qualification

Before use: Clofarabine IV injection (Clolar)

Renal thresholds agree in the selected passages, but source revisions differ (manufacturer 2019; RX 2022). Full current-label reconciliation is pending.

Before applying: Confirm the current oncology protocol, exact patient population and label before use. No recommendation is inferred for CrCl <30 or dialysis.

Evidence for this qualification

Selected source reconciliation only; independent clinician adjudication pending.

Confirm the product, indication and renal measure. The selected summary is not a complete prescribing monograph.

Choose a source to read (2)

Display order is not a clinical ranking. Date of retrieval is not the label revision date. Sources are never merged into one regimen. Other sources and conflicts remain below.

Official source

Clofarabine IV injection (Clolar) - selected label sections

Product / population
CLOLAR IV injection: labeled pediatric population ages 1 to 21 with relapsed/refractory ALL after at least two prior regimens. Not a general adult oncology dosing protocol.
Renal measure
Creatinine clearance (CrCl), mL/min, as stated in the label; retain the source-specific age and renal-assessment context.
Source revision
12/2019
Retrieved
2026-10-02 (not the revision date)

The official product label and its RX mirror are one underlying evidence family, not two independent clinical validations. Confirm the current exact product label before prescribing.

Renal guidance and important limits

Limits that apply to these rows

Labeled baseline regimen is 52 mg/m2 IV over 2 hours daily for 5 consecutive days. Baseline renal reduction and later toxicity-driven changes are separate decisions.

Monitor renal function and minimize nephrotoxic co-medications during treatment. Oncology protocol review is required.

Source currency limitation: manufacturer page is dated 12/2019, whereas the RX mirror is dated 07/2022. The shared selected renal instructions do not establish that the full older label is current.

Clofarabine IV injection (Clolar) - selected renal instructions
Renal settingSource-specific action and limits
CrCl 30 to 60 mL/min, including 60Reduce the starting dose by 50%. This is not a newly calculated patient-specific dose.
CrCl <30 mL/min or dialysisInsufficient information for a recommended dose. Do not extrapolate the 50% reduction.
Read the retained text before reformatting
Renal settingSource-specific action and limits
CrCl 30 to 60 mL/min, including 60Reduce the starting dose by 50%. This is not a newly calculated patient-specific dose.
CrCl <30 mL/min or dialysisInsufficient information for a recommended dose. Do not extrapolate the 50% reduction.

Labeled baseline regimen is 52 mg/m2 IV over 2 hours daily for 5 consecutive days. Baseline renal reduction and later toxicity-driven changes are separate decisions.

Monitor renal function and minimize nephrotoxic co-medications during treatment. Oncology protocol review is required.

Source currency limitation: manufacturer page is dated 12/2019, whereas the RX mirror is dated 07/2022. The shared selected renal instructions do not establish that the full older label is current.

Source revision: 12/2019 | Retrieved: 2026-10-02. Retrieval date is not the revision date.

Source: https://products.sanofi.us/clolar/clolar.html

Scope: Selected renal sections summarized locally. Not a complete monograph or independent clinical approval. GlobalRPh v6.8.

Full source card / provenance

All sources, comparison tools and evidence navigation
Added / rechecked in v6.8

Read source findings

Read source-specific summaries and their qualifications. Retrieval date is not label revision date. Recent review does not imply clinical approval.

Official

Clofarabine IV injection (Clolar) - selected label sections

Before using this finding

Confirm the current oncology protocol, exact patient population and label before use. No recommendation is inferred for CrCl <30 or dialysis.

Dialysis evidence: No dialysis regimen established in selected content

Retrieved: 2026-10-02
Source revision: 12/2019

Renal measure: Creatinine clearance (CrCl), mL/min, as stated in the label; retain the source-specific age and renal-assessment context.

Read this dated source finding
Rxlist

Clofarabine IV injection (Clolar) - RX mirror renal summary

Before using this finding

Confirm the current oncology protocol, exact patient population and label before use. No recommendation is inferred for CrCl <30 or dialysis.

Dialysis evidence: No dialysis regimen established in selected content

Retrieved: 2026-10-02
Source revision: 07/2022

Renal measure: Creatinine clearance (CrCl), mL/min, as stated in the label; retain the source-specific age and renal-assessment context.

Read this dated source finding
See all retained evidence sources
Source-specific interpretation

What the dialysis evidence actually supports

Removal information alone does not define a maintenance dose, supplemental dose or dialysis schedule. A reported regimen still requires its product, indication, renal measure and dialysis assumptions to match the patient.

Clofarabine IV injection (Clolar) - selected label sections

Source retrieved 2026-10-02

No dialysis regimen established in selected content

Read the source and its limits

Clofarabine IV injection (Clolar) - RX mirror renal summary

Source retrieved 2026-10-02

No dialysis regimen established in selected content

Read the source and its limits

These manual classifications apply only to the identified selected sections, not every retained source or the entire prescribing information. They are not dosing clearance.

Source-first renal review

Evidence sources and renal implications

Choose a source to jump directly to its locally stored result. Qualitative precautions and evidence gaps remain visible even when no numerical clearance schedule is supplied.

Read 1 source difference / applicability notes

Official product label

Clofarabine IV injection (Clolar) - selected label sections

Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.
Before using this finding

Confirm the current oncology protocol, exact patient population and label before use. No recommendation is inferred for CrCl <30 or dialysis.

Dialysis evidence: No dialysis regimen established in selected content

CLOLAR IV injection: labeled pediatric population ages 1 to 21 with relapsed/refractory ALL after at least two prior regimens. Not a general adult oncology dosing protocol.

Renal method: Creatinine clearance (CrCl), mL/min, as stated in the label; retain the source-specific age and renal-assessment context.
Retrieved: 2026-10-02

Read local renal resultOpen original reference
GlobalRPh RX List

Clofarabine IV injection (Clolar) - RX mirror renal summary

Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.
Before using this finding

Confirm the current oncology protocol, exact patient population and label before use. No recommendation is inferred for CrCl <30 or dialysis.

Dialysis evidence: No dialysis regimen established in selected content

CLOLAR IV injection: labeled pediatric population ages 1 to 21 with relapsed/refractory ALL after at least two prior regimens. Not a general adult oncology dosing protocol.

Renal method: Creatinine clearance (CrCl), mL/min, as stated in the label; retain the source-specific age and renal-assessment context.
Retrieved: 2026-10-02

Read local renal resultOpen original reference

Source presence is not independent validation. A label mirror is not a second independent source; review the original reference and exact formulation.

Find text within this drug
Find a term without leaving this drug

Search the stored clinical text

Locate a word or phrase within this drug's source summaries. Choose all sources or one source to focus the search. The selection never hides warnings or source text, changes a dose, or proves that a renal finding is absent.

Find:

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All source summaries, original wording and provenance
Before applying a renal protocol

Check the setting. Compare whole sources.

No patient-specific dose is calculated. Context choices only display reminders; they do not validate, hide or change any regimen.

Share a reproducible source review

Choose sources below, then open a print-ready comparison with product scope, renal method, dates and cautions. Links can pin the exact local cards; they never contain patient values or choose a dose.

Open / share selected sources
Jump to renal guidanceRead 1 difference / caution notesClinician guide

Select two distinct source versions. The complete stored summaries will appear below.

Build a source-review outline for documentation

This creates a blank decision outline with the source identities you select, not a dose recommendation or completed clinical assessment. No patient fields are collected, saved or sent. Complete the clinical decisions in your approved documentation system.

Choose one or two sources above or use the source checkboxes below.

Renal-context checklist: population, kidney trend and dialysis

These prompts are a reading aid, not a prescription checklist or proof that all requirements have been met. No selections are stored or sent to a server.

Read the exact source scope, renal metric and date before selecting a row. No applicability assessment has been performed.

See source-specific renal methods and the clinical interpretation guide for the supporting context.

Read before choosing a regimen

Source differences and product cautions

Search differences across all drugs

These are specific issues found during source review, not an automated judgment that one source is universally correct. A label mirror and its original label are not independent evidence.

source scope and renal guidance

Before use: Clofarabine IV injection (Clolar)

Renal thresholds agree in the selected passages, but source revisions differ (manufacturer 2019; RX 2022). Full current-label reconciliation is pending.

How to use this: Confirm the current oncology protocol, exact patient population and label before use. No recommendation is inferred for CrCl <30 or dialysis.

Clofarabine IV injection (Clolar) - selected label sectionsClofarabine IV injection (Clolar) - RX mirror renal summary

Selected source reconciliation only; independent clinician adjudication pending.

Go directly to the relevant source section

Renal dosing and precautions

Choose a source, then jump to its renal or dialysis section. These links locate stored text; they do not merge regimens or certify that sources agree.

Independent clinical review is pending. These selected summaries are not an approved institutional dosing protocol. Confirm the exact product, the complete current source and local policy before use.
Official source

Clofarabine IV injection (Clolar) - selected label sections

CLOLAR IV injection: labeled pediatric population ages 1 to 21 with relapsed/refractory ALL after at least two prior regimens. Not a general adult oncology dosing protocol.

Method: Creatinine clearance (CrCl), mL/min, as stated in the label; retain the source-specific age and renal-assessment context.

Renal guidance and important limitsRead this complete source summary
Rxlist source

Clofarabine IV injection (Clolar) - RX mirror renal summary

CLOLAR IV injection: labeled pediatric population ages 1 to 21 with relapsed/refractory ALL after at least two prior regimens. Not a general adult oncology dosing protocol.

Method: Creatinine clearance (CrCl), mL/min, as stated in the label; retain the source-specific age and renal-assessment context.

Renal guidance and important limitsRead this complete source summary

No dialysis or renal heading shown? Read the complete source summary. Absence of a heading is not evidence that dose adjustment is unnecessary.

Compare or copy source versions

All content below is stored locally. Read a whole source version; do not combine its dose with another source's interval, renal metric or dialysis assumptions.

Original content / product scopeClofarabine IV injection (Clolar) - selected label sectionsClofarabine IV injection (Clolar) - RX mirror renal summary
Choose two source checkboxes below.
Exact product and population matter. This added page contains locally stored, source-specific clinical summaries. Historical handbook information, when present, is identified separately and may conflict with U.S. labeling. Confirm indication, population, kidney-function method, monitoring and the full prescribing information before applying a regimen.

Important source distinctions

The official product label and its RX mirror are one underlying evidence family, not two independent clinical validations. Confirm the current exact product label before prescribing.

Locally stored source content

Exact product and population

Product identity selected for the separately displayed source protocols below. Reference: https://products.sanofi.us/clolar/clolar.html

Exact product and population

CLOLAR IV injection: labeled pediatric population ages 1 to 21 with relapsed/refractory ALL after at least two prior regimens. Not a general adult oncology dosing protocol.

RDM68-clofarabine-clolar-808ff2287f · Source section: Selected primary product label: indications / formulationRenal section finder
Separate U.S. product-label layer

FDA / DailyMed dosing and renal information

Official

Clofarabine IV injection (Clolar) - selected label sections

Open original reference

Open / share this exact local source

Sanofi / CLOLAR prescribing information · CLOLAR IV injection: labeled pediatric population ages 1 to 21 with relapsed/refractory ALL after at least two prior regimens. Not a general adult oncology dosing protocol.

Renal method: Creatinine clearance (CrCl), mL/min, as stated in the label; retain the source-specific age and renal-assessment context.
Source date: 12/2019
Retrieved: 2026-10-02

Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.
Before using this finding

Confirm the current oncology protocol, exact patient population and label before use. No recommendation is inferred for CrCl <30 or dialysis.

Dialysis evidence: No dialysis regimen established in selected content

Selected renal sections summarized locally. Not a complete monograph or independent clinical approval.

Renal guidance and important limits

Limits that apply to these rows

Labeled baseline regimen is 52 mg/m2 IV over 2 hours daily for 5 consecutive days. Baseline renal reduction and later toxicity-driven changes are separate decisions.

Monitor renal function and minimize nephrotoxic co-medications during treatment. Oncology protocol review is required.

Source currency limitation: manufacturer page is dated 12/2019, whereas the RX mirror is dated 07/2022. The shared selected renal instructions do not establish that the full older label is current.

Clofarabine IV injection (Clolar) - selected renal instructions
Renal settingSource-specific action and limits
CrCl 30 to 60 mL/min, including 60Reduce the starting dose by 50%. This is not a newly calculated patient-specific dose.
CrCl <30 mL/min or dialysisInsufficient information for a recommended dose. Do not extrapolate the 50% reduction.
Read the retained text before reformatting
Renal settingSource-specific action and limits
CrCl 30 to 60 mL/min, including 60Reduce the starting dose by 50%. This is not a newly calculated patient-specific dose.
CrCl <30 mL/min or dialysisInsufficient information for a recommended dose. Do not extrapolate the 50% reduction.

Labeled baseline regimen is 52 mg/m2 IV over 2 hours daily for 5 consecutive days. Baseline renal reduction and later toxicity-driven changes are separate decisions.

Monitor renal function and minimize nephrotoxic co-medications during treatment. Oncology protocol review is required.

Source currency limitation: manufacturer page is dated 12/2019, whereas the RX mirror is dated 07/2022. The shared selected renal instructions do not establish that the full older label is current.

RDM68-clofarabine-clolar-fb7a592eaf · Source locator: Sections 1, 2.1, 2.2, 5.8 and 8.7

Source-specific limits

The official product label and its RX mirror are one underlying evidence family, not two independent clinical validations. Confirm the current exact product label before prescribing.

Source identity and provenance
Source family
product_label
Source
https://products.sanofi.us/clolar/clolar.html
Retrieved
2026-10-02
Renal-function method
Creatinine clearance (CrCl), mL/min, as stated in the label; retain the source-specific age and renal-assessment context.
Source date/version
12/2019
Hash meaning
Local authored summary; not source HTML/XML/PDF bytes
Local summary SHA-256
fb7a592eafd7715d3f8580269f797289b8a1ac82fe3d14446169776e204ee281
Locally imported selected renal sections

GlobalRPh RX List renal information

Rxlist

Clofarabine IV injection (Clolar) - RX mirror renal summary

Open original reference

Open / share this exact local source

GlobalRPh RX List / product-label mirror · CLOLAR IV injection: labeled pediatric population ages 1 to 21 with relapsed/refractory ALL after at least two prior regimens. Not a general adult oncology dosing protocol.

Renal method: Creatinine clearance (CrCl), mL/min, as stated in the label; retain the source-specific age and renal-assessment context.
Source date: 07/2022
Retrieved: 2026-10-02

Label mirror, not independent corroboration. This is selected locally stored RX List content. Full monograph import and current official-label review are not implied.
Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.
Before using this finding

Confirm the current oncology protocol, exact patient population and label before use. No recommendation is inferred for CrCl <30 or dialysis.

Dialysis evidence: No dialysis regimen established in selected content

Selected renal sections summarized locally. Not a complete monograph or independent clinical approval.

Renal guidance and important limits

The July 2022 mirror directs a 50% starting-dose reduction at CrCl 30-60 mL/min. It gives no recommended dose below 30 or during dialysis. It warns about acute renal failure and recommends monitoring with interruption or discontinuation as necessary. The labeled population is ages 1-21 with relapsed/refractory ALL.

RDM68-clofarabine-clolar-105237d650 · Source locator: Named RX renal impairment, dosage and renal-warning sections

Source-specific limits

The official product label and its RX mirror are one underlying evidence family, not two independent clinical validations. Confirm the current exact product label before prescribing.

Source identity and provenance
Source family
product_label
Source
https://globalrph.com/rx-list/clolar-drug/
Retrieved
2026-10-02
Renal-function method
Creatinine clearance (CrCl), mL/min, as stated in the label; retain the source-specific age and renal-assessment context.
Source date/version
07/2022
Hash meaning
Local authored summary; not source HTML/XML/PDF bytes
Local summary SHA-256
105237d6501f27f1b6135bf6c3ad72fada28ec7bbe3fe3ed154464d9626d1f3b

Provenance and preservation

Additional summaries stored on this page: 1 official-label, 1 RX List, 0 professional, 0 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source
https://products.sanofi.us/clolar/clolar.html
Source retrieval
2026-10-02. This is not the source publication or label revision date.
Original source type
multisource addition
Local text SHA-256
808ff2287fcd517a179045a7aeae9b286fd56899df51c0e7f3b67e31a20c28ad
Import versus clinical validation
Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

This page is an additional exact-product entry, not a recovered GlobalRPh monograph. Its primary scope text and separately attributed clinical summaries are locally included.

Read the full coverage report