GlobalRPh Renal Dosing Masterv6.6
GlobalRPh source record

Ciprofloxacin

GlobalRPh source pageBase record retrieved 2026-09-05See the evidence for this drug2 sources available - open source summaries, references and comparisons
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Professional source

UCSF - ciprofloxacin

Product / population
Adults; systemic oral or IV ciprofloxacin, not otic/ophthalmic products.
Renal measure
CrCl in mL/min where specified; no equation inferred.

Dosing / renal protocol and limits

Standard treatment at CrCl >=30 mL/min uses either 400 mg IV every 12 hours or 500 mg orally twice daily. Below 30, use either 400 mg IV daily or 500 mg orally daily.

For Pseudomonas, Gram-negative bacteremia or induction of staphylococcal hardware infection, CrCl >50 uses 400 mg IV every 8 hours or 750 mg orally every 12 hours; CrCl 30-50 uses 400 mg IV or 500 mg orally every 12 hours; below 30 uses the daily regimen above.

IHD: 400 mg IV or 500 mg orally each evening. CVVHD: 400 mg IV every 8 hours or 500 mg orally every 12 hours. IV and oral choices are alternatives, not concurrent doses.

Source revision: Revision date not stated in the reviewed page. | Retrieved: 2026-09-05. Retrieval date is not the revision date.

Source: https://idmp.ucsf.edu/content/ciprofloxacin

Scope: Locally included source-specific summary. Regimen differences are not automatically resolved. GlobalRPh v6.6.

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Retrieved: 2026-09-05

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Professional guidance

UCSF - ciprofloxacin

Adults; systemic oral or IV ciprofloxacin, not otic/ophthalmic products.

Renal method: CrCl in mL/min where specified; no equation inferred.
Retrieved: 2026-09-05

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Original content / product scopeUCSF - ciprofloxacin
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Original GlobalRPh protocol

Clinical facts and comments transcribed into a structured reading format. This is not a byte-for-byte HTML archive. Original source: https://globalrph.com/renal/ciprofloxacin/

Usual Dosing (Adults)

Oral: 250 to 750 mg every 12 hours. IV: 200 to 400 mg every 12 hours. Febrile neutropenia: 400 mg IV every 8 hours.

Ciprofloxacin injection is administered by IV infusion over 60 minutes. Slowly infusing a dilute solution into a larger vein minimizes discomfort and venous irritation. Individual dosing considers infection severity/nature, organism susceptibility, host defenses and renal/hepatic function.

Source IV adult dosage guidelines:

Infection/severityDoseIntervalUsual duration
Urinary tract, mild/moderate200 mgEvery 12 hours7 to 14 days
Urinary tract, severe/complicated400 mgEvery 12 hours7 to 14 days
Lower respiratory, mild/moderate400 mgEvery 12 hours7 to 14 days
Lower respiratory, severe/complicated400 mgEvery 8 hours7 to 14 days
Nosocomial pneumonia, mild/moderate/severe400 mgEvery 8 hours10 to 14 days
Skin/skin structure, mild/moderate400 mgEvery 12 hours7 to 14 days
Skin/skin structure, severe/complicated400 mgEvery 8 hours7 to 14 days
Bone/joint, mild/moderate400 mgEvery 12 hours>=4 to 6 weeks
Bone/joint, severe/complicated400 mgEvery 8 hours>=4 to 6 weeks
Complicated intra-abdominal, with metronidazole400 mgEvery 12 hours7 to 14 days
Acute sinusitis, mild/moderate400 mgEvery 12 hours10 days
Chronic bacterial prostatitis, mild/moderate400 mgEvery 12 hours28 days
Severe febrile neutropenia, empirical therapyCiprofloxacin 400 mg plus piperacillin 50 mg/kg (piperacillin maximum 24 g/day)Ciprofloxacin every 8 hours; piperacillin every 4 hours7 to 14 days
Inhalational anthrax post-exposure400 mgEvery 12 hours60 days total IV plus oral

These indications refer to the designated pathogens. For anthrax, initiate as soon as possible after suspected or confirmed exposure; the source notes that the indication is based on serum concentrations as a surrogate endpoint reasonably likely to predict benefit.

Parenteral therapy may be switched to oral tablets or suspension when warranted at the physician's discretion.

Equivalent AUC regimens:

Oral doseEquivalent IV dose
250 mg every 12 hours200 mg every 12 hours
500 mg every 12 hours400 mg every 12 hours
750 mg every 12 hours400 mg every 8 hours
GRPH-ciprofloxacin-01 · Source section: Usual Dosing (Adults)Renal section finder

Renal Dosing

Manufacturer's recommendations as reproduced on the GlobalRPh source:

Oral immediate-release: CrCl >50 mL/min no adjustment; 30 to 50: 250 to 500 mg every 12 hours; 5 to 29: 250 to 500 mg every 18 hours. ESRD on intermittent hemodialysis or peritoneal dialysis: 250 to 500 mg every 24 hours, after dialysis on dialysis days.

IV: CrCl >=30 mL/min no adjustment; 5 to 29: 200 to 400 mg every 18 to 24 hours.

Alternative strategy (the source cites Drug Prescribing in Renal Failure): oral and IV, CrCl >50 mL/min no adjustment; 10 to 50: 50% to 75% of usual dose every 12 hours; <10: 50% of usual dose every 12 hours.

GRPH-ciprofloxacin-02 · Source section: Renal DosingRenal section finder

Hemodialysis

See the manufacturer regimen above. The separate source dialysis section also lists: IV 200 to 400 mg every 24 hours or 200 mg every 12 hours; oral 250 mg every 12 hours or 250 to 500 mg every 24 hours. Schedule doses after dialysis on dialysis days.

GRPH-ciprofloxacin-03 · Source section: HemodialysisRenal section finder
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University and professional protocols

Professional

UCSF - ciprofloxacin

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UCSF Infectious Diseases Management Program · Adults; systemic oral or IV ciprofloxacin, not otic/ophthalmic products.

Renal method: CrCl in mL/min where specified; no equation inferred.
Source date: Revision date not stated in the reviewed page.
Retrieved: 2026-09-05

Locally included source-specific summary. Regimen differences are not automatically resolved.

Dosing / renal protocol and limits

Standard treatment at CrCl >=30 mL/min uses either 400 mg IV every 12 hours or 500 mg orally twice daily. Below 30, use either 400 mg IV daily or 500 mg orally daily.

For Pseudomonas, Gram-negative bacteremia or induction of staphylococcal hardware infection, CrCl >50 uses 400 mg IV every 8 hours or 750 mg orally every 12 hours; CrCl 30-50 uses 400 mg IV or 500 mg orally every 12 hours; below 30 uses the daily regimen above.

IHD: 400 mg IV or 500 mg orally each evening. CVVHD: 400 mg IV every 8 hours or 500 mg orally every 12 hours. IV and oral choices are alternatives, not concurrent doses.

RDM30-014-ciprofloxacin-1 · Source locator: UCSF - ciprofloxacin; renal/dosing sections and stated qualifiers

Source identity and provenance
Source
https://idmp.ucsf.edu/content/ciprofloxacin
Retrieved
2026-09-05
Renal-function method
CrCl in mL/min where specified; no equation inferred.
Source date/version
Revision date not stated in the reviewed page.
Hash meaning
Locally authored summary text; not original SPL, HTML or PDF bytes
Local summary SHA-256
86db8f0afc9eeb7edb694a1236289e44daf06c815e01bd2366ad685857f29c24

Provenance and preservation

Additional summaries stored on this page: 0 official-label, 0 RX List, 1 professional, 0 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source
https://globalrph.com/renal/ciprofloxacin/
Source retrieval
2026-09-05. This is not the source publication or label revision date.
Original source type
globalrph individual
Local text SHA-256
78b738cbfbf14b04752cd9e0dff91dca9803903b65924d20484ffa9688623318
Import versus clinical validation
Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

The original individual GlobalRPh pages commonly cite NIH/NLM DailyMed and instruct readers to review the applicable package insert for updates. That historical reference is preserved as context; it is not counted as an independently retrieved current label.

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