GlobalRPh Renal Dosing Masterv6.6
Evidence addition

Cefuroxime sodium - injection

Local official-label summaryBase record retrieved 2026-09-05See the evidence for this drug2 sources available - open source summaries, references and comparisons

cefuroxime sodium / Zinacef

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Official source

Cefuroxime sodium for injection, USP

Product / population
Adult IV/IM powder for solution; Sagent product.
Renal measure
Not specified; verify before use
Usual adult dosing

Usual infections: 750 mg to 1.5 g every 8 hours. Severe/complicated or bone/joint infections: 1.5 g every 8 hours. Life-threatening infection may require 1.5 g every 6 hours; meningitis dosing must not exceed 3 g every 8 hours.

Renal adjustment

CrCl >20 mL/min: 750 mg to 1.5 g every 8 hours; 10-20: 750 mg every 12 hours; <10: 750 mg every 24 hours. The label directs an additional dose at the end of HD because cefuroxime is dialyzable. Do not apply the oral axetil schedule to this injectable product.

Source revision: | Retrieved: 2026-09-05. Retrieval date is not the revision date.

Source: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=0a145288-733a-4966-b7ae-dc96eb103d8c

Scope: Source-read local summary; source-specific recommendations are not automatically interchangeable. GlobalRPh v6.6.

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Evidence sources and renal implications

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GlobalRPh RX List

GlobalRPh RX List - ZINACEF

Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.

Adult parenteral cefuroxime sodium; not oral axetil.

Renal method: Adult creatinine clearance, mL/min; steady-state creatinine assumption.
Retrieved: 2026-09-07

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Original content / product scopeCefuroxime sodium for injection, USPGlobalRPh RX List - ZINACEF
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Exact product and population matter. This added page contains locally stored, source-specific clinical summaries. Historical handbook information, when present, is identified separately and may conflict with U.S. labeling. Confirm indication, population, kidney-function method, monitoring and the full prescribing information before applying a regimen.
Locally stored source content

Exact product and population

Product identity selected for the separately displayed source protocols below. Reference: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=0a145288-733a-4966-b7ae-dc96eb103d8c

Product and population scope

Adult IV/IM cefuroxime sodium; not oral cefuroxime axetil. Select the correct formulation before applying renal doses.

cefuroxime-injection:scope · Source section: Selected U.S. label: product title, route, dosage form and indicationRenal section finder
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FDA / DailyMed dosing and renal information

Official

Cefuroxime sodium for injection, USP

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NIH/NLM DailyMed - U.S. prescribing information · Adult IV/IM powder for solution; Sagent product.

Renal method: Not specified in this summary.
Source date:
Retrieved: 2026-09-05

Source-read local summary; source-specific recommendations are not automatically interchangeable.

Usual adult dosing

Usual infections: 750 mg to 1.5 g every 8 hours. Severe/complicated or bone/joint infections: 1.5 g every 8 hours. Life-threatening infection may require 1.5 g every 6 hours; meningitis dosing must not exceed 3 g every 8 hours.

cefuroxime-injection:dm-0a145288-733a-4966-b7ae-dc96eb103d8c-1 · Source locator: Dosage and Administration: Adults

Renal adjustment

CrCl >20 mL/min: 750 mg to 1.5 g every 8 hours; 10-20: 750 mg every 12 hours; <10: 750 mg every 24 hours. The label directs an additional dose at the end of HD because cefuroxime is dialyzable. Do not apply the oral axetil schedule to this injectable product.

cefuroxime-injection:dm-0a145288-733a-4966-b7ae-dc96eb103d8c-2 · Source locator: Dosage and Administration: Impaired Renal Function, Table 2

Source identity and provenance
Source
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=0a145288-733a-4966-b7ae-dc96eb103d8c
Retrieved
2026-09-05
Exact label title
Cefuroxime sodium for injection, USP
DailyMed Set ID
0a145288-733a-4966-b7ae-dc96eb103d8c
Labeler
Sagent Pharmaceuticals
DailyMed page updated
2025-03-27
FDA application
Abbreviated New Drug Application
U.S. product identity basis
Exact named product and route appear in the selected U.S. prescription label; current retail availability was not independently assessed.
Hash meaning
Locally authored source summary, not original SPL/XML/PDF bytes
Local summary SHA-256
57bd4a59db519fbd01448d49911d3e057719cbfced6a830536e36d18471dc883
Locally imported selected renal sections

GlobalRPh RX List renal information

Rxlist

GlobalRPh RX List - ZINACEF

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GlobalRPh-hosted RX List · Adult parenteral cefuroxime sodium; not oral axetil.

Renal method: Adult creatinine clearance, mL/min; steady-state creatinine assumption.
Source date: Source revision date not established in selected retrieval.
Retrieved: 2026-09-07

Label mirror, not independent corroboration. This is selected locally stored RX List content. Full monograph import and current official-label review are not implied.
Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.

Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph.

Renal dosing, restrictions and evidence limits

Adult injection doses: CrCl above 20 mL/min, 750 mg to 1.5 g every eight hours; CrCl 10-20, 750 mg every twelve hours; below 10, 750 mg every twenty-four hours. The source calls for a further dose after each hemodialysis session but does not specify that supplemental amount in the selected footnote. Its creatinine-clearance equation assumes steady-state serum creatinine. These are injection instructions, not the oral cefuroxime-axetil schedule.

RDM37-rxlist-cefuroxime-injection-0ae769cdf2-C1 · Source locator: Dosage Table 2 and dialysis footnote.

Source identity and provenance
Source family
product_label_mirror
Source
https://globalrph.com/rx-list/zinacef-drug/
Retrieved
2026-09-07
Renal-function method
Adult creatinine clearance, mL/min; steady-state creatinine assumption.
Source date/version
Source revision date not established in selected retrieval.
Hash meaning
SHA-256 of local authored summary only; not original HTML, PDF or SPL bytes.
Local summary SHA-256
3a74ee234d0d1a044b0c0a645e2355a883090bae0f306967fa041982fc1a2b93

Provenance and preservation

Additional summaries stored on this page: 1 official-label, 1 RX List, 0 professional, 0 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=0a145288-733a-4966-b7ae-dc96eb103d8c
Source retrieval
2026-09-05. This is not the source publication or label revision date.
Original source type
official formulation addition
Local text SHA-256
23c9227ba24038e717ea5a66b87733dbb668f0cf82b2010f32ac40566e54d401
Import versus clinical validation
Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

This page is an additional exact-product entry, not a recovered GlobalRPh monograph. Its primary scope text and separately attributed clinical summaries are locally included.

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