GlobalRPh Renal Dosing Masterv6.6
GlobalRPh source record

Ceftriaxone

GlobalRPh source pageBase record retrieved 2026-09-05See the evidence for this drug3 sources available - open source summaries, references and comparisons

Rocephin

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Professional source

UCSF - ceftriaxone

Product / population
Adults; source-specific institutional guidance. Match route, indication and renal replacement modality.
Renal measure
No routine renal dose adjustment in the listed adult indications.

Dosing / renal protocol and limits

Adult IV regimens are not routinely reduced for kidney dysfunction or hemodialysis in this source. Standard treatment uses 2 g daily; UTI uses 1 g daily. Meningitis and enterococcal endocarditis treated with concomitant ampicillin use 2 g every 12 hours. Obesity (BMI >30) can warrant individualized higher dosing with ID/pharmacy input. The indication-specific regimen is retained rather than treating all renal patients as receiving one dose.

Source revision: Revision date not stated in the reviewed page. | Retrieved: 2026-09-05. Retrieval date is not the revision date.

Source: https://idmp.ucsf.edu/content/ceftriaxone

Scope: Locally included source-specific summary. Regimen differences are not automatically resolved. GlobalRPh v6.6.

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Evidence sources and renal implications

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Preserved GlobalRPh source

Preserved original GlobalRPh source

Preserved historical content; not revalidated as current prescribing guidance.

Renal method: Read the measure and population stated in the original source sections.
Retrieved: 2026-09-05

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Professional guidance

UCSF - ceftriaxone

Adults; source-specific institutional guidance. Match route, indication and renal replacement modality.

Renal method: No routine renal dose adjustment in the listed adult indications.
Retrieved: 2026-09-05

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Renal dosing and precautions

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Professional source

Stanford adult Ceftriaxone

Adult institutional dosing; not a manufacturer-label replacement.

Method: Not stated in selected source.

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Original content / product scopeStanford adult CeftriaxoneUCSF - ceftriaxone
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Historical source content is not a current prescription. Original GlobalRPh recommendations are preserved, not automatically certified as current. Product-label and professional additions below are separately attributed. Confirm indication, population, kidney-function method, monitoring and the full prescribing information before applying a regimen.

Important source distinctions

The gonorrhea regimen and dialysis comments are preserved historical GlobalRPh content, not a statement of current guideline recommendations.

Locally stored source content

Original GlobalRPh protocol

Clinical facts and comments transcribed into a structured reading format. This is not a byte-for-byte HTML archive. Original source: https://globalrph.com/renal/ceftriaxone/

Usual Dosing (Adults)

Adults: 1 to 2 grams daily, once daily or in two equal doses. For MSSA the source comments that 2 to 4 g/day may be required to achieve >90% target attainment. Maximum 4 g/day.

If chlamydial infection is suspected, add appropriate coverage because ceftriaxone has no activity against this organism. The historical source lists gonorrhea: 250 mg IM once. Surgical prophylaxis: 1 g IV 0.5 to 2 hours before surgery.

Continue therapy for at least 2 days after signs and symptoms have disappeared. Usual duration is 4 to 14 days; complicated infections may require longer. S. pyogenes infections require at least 10 days. No dose adjustment is necessary with renal or hepatic dysfunction alone.

GRPH-ceftriaxone-01 · Source section: Usual Dosing (Adults)Renal section finder

Renal Dosing

No renal adjustment; monitor blood levels in dialysis patients. In patients with both renal and hepatic dysfunction, dosage should not exceed 2 g/day.

GRPH-ceftriaxone-02 · Source section: Renal DosingRenal section finder

Hemodialysis

No specific manufacturer recommendations beyond blood-level monitoring; the source states dosage should not exceed 2 g/day. Peritoneal dialysis: 750 mg every 12 hours.

GRPH-ceftriaxone-03 · Source section: HemodialysisRenal section finder
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University and professional protocols

Professional

Stanford adult Ceftriaxone

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Stanford Antimicrobial Safety and Sustainability Program · Adult institutional dosing; not a manufacturer-label replacement.

Renal method: Not specified in this summary.
Source date: Antibiotic Subcommittee approved August 2026
Retrieved: 2026-09-05

Source-read local summary; source-specific recommendations are not automatically interchangeable.

Source-specific regimen

Adult IV: usual 1-2 g daily; endovascular, osteomyelitis or PJI 2 g daily; meningitis or E. faecalis endocarditis 2 g every 12 hours. The table specifies no renal, HD or CRRT change.

ceftriaxone:stanford-ceftriaxone-1 · Source locator: PDF page 3, Ceftriaxone row

Source identity and provenance
Source
https://med.stanford.edu/content/dam/sm/bugsanddrugs/documents/antimicrobial-dosing-protocols/SHC-ABX-Dosing-Guide.pdf
Retrieved
2026-09-05
Source date/version
Antibiotic Subcommittee approved August 2026
Hash meaning
Locally authored source summary, not original SPL/XML/PDF bytes
Local summary SHA-256
45cb208904dffa9eee53ddc70939dfd3651de0499f58be0262542afaaccfde4d
Professional

UCSF - ceftriaxone

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UCSF Infectious Diseases Management Program · Adults; source-specific institutional guidance. Match route, indication and renal replacement modality.

Renal method: No routine renal dose adjustment in the listed adult indications.
Source date: Revision date not stated in the reviewed page.
Retrieved: 2026-09-05

Locally included source-specific summary. Regimen differences are not automatically resolved.

Dosing / renal protocol and limits

Adult IV regimens are not routinely reduced for kidney dysfunction or hemodialysis in this source. Standard treatment uses 2 g daily; UTI uses 1 g daily. Meningitis and enterococcal endocarditis treated with concomitant ampicillin use 2 g every 12 hours. Obesity (BMI >30) can warrant individualized higher dosing with ID/pharmacy input. The indication-specific regimen is retained rather than treating all renal patients as receiving one dose.

RDM30-012-ceftriaxone-1 · Source locator: UCSF - ceftriaxone; renal/dosing sections and stated qualifiers

Source identity and provenance
Source
https://idmp.ucsf.edu/content/ceftriaxone
Retrieved
2026-09-05
Renal-function method
No routine renal dose adjustment in the listed adult indications.
Source date/version
Revision date not stated in the reviewed page.
Hash meaning
Locally authored summary text; not original SPL, HTML or PDF bytes
Local summary SHA-256
260d56a9a4edd87b1c0433d53c1d2fd8a060bbcd37cf51329a55a07d6486e2cb

Provenance and preservation

Additional summaries stored on this page: 0 official-label, 0 RX List, 2 professional, 0 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source
https://globalrph.com/renal/ceftriaxone/
Source retrieval
2026-09-05. This is not the source publication or label revision date.
Original source type
globalrph individual
Local text SHA-256
f45ea5dd8930c1eb574fa71cb4e2b1c26b68db34a2c47b45d7f0d7f6507f9d8c
Import versus clinical validation
Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

The original individual GlobalRPh pages commonly cite NIH/NLM DailyMed and instruct readers to review the applicable package insert for updates. That historical reference is preserved as context; it is not counted as an independently retrieved current label.

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