Ceftolozane / tazobactam (Zerbaxa)

All adult doses are total combination amounts, IV every 8 hours over 1 hour. For cIAI/cUTI, baseline is 1.5 g; for HABP/VABP, 3 g. Add metronidazole for cIAI.

On IHD days administer as soon as possible after completion. Monitor changing CrCl at least daily. The 51-to-<90 label band retains baseline doses. Pediatric renal and infusion schedules are separate and must not be inferred from these adult doses.

Age 2 to below 18 years: use a validated pediatric eGFR equation (mL/min/1.73 m2). For cIAI/cUTI, total combination mg/kg every eight hours at eGFR 51 to below 90, 30-50 and 15-29 are respectively 30, 15 and 7.5; infuse over one hour. For HABP/VABP, corresponding doses are 75, 37.5 and 18.75 mg/kg every eight hours over two hours. Intermittent HD: cIAI/cUTI loads 15 mg/kg then 3 mg/kg every eight hours; pneumonia loads 45 mg/kg then 9 mg/kg every eight hours. Give post-HD doses as early as possible after dialysis. Above 50 kg for cIAI/cUTI or 40 kg for pneumonia, do not exceed the adult renal dose. Below eGFR 15 without HD, dosing is not established. Renal-impairment dosing is not recommended below age two. Reassess changing eGFR daily. cIAI also requires metronidazole. These 2026 regimens supersede the older mirror's broad pediatric renal evidence gap.

All doses are the combined ceftolozane/tazobactam quantity and are infused over one hour. On dialysis days give as soon as possible after dialysis. For changing renal function, assess CrCl at least daily and adjust accordingly. These are adult recommendations; no pediatric fallback is supplied. The three-hour infusion used in some institutional protocols is a separate source-specific approach.

Adult doses are total combination amounts, each infused over one hour every eight hours. For complicated intra-abdominal or urinary infection, the source uses 1.5 g above CrCl 50, 750 mg at 30-50, and 375 mg at 15-29 mL/min. For hospital-acquired/ventilator-associated pneumonia, corresponding doses are 3 g, 1.5 g and 750 mg. Hemodialysis: the abdominal/urinary regimen is a 750 mg loading dose then 150 mg every eight hours; pneumonia uses 2.25 g then 450 mg every eight hours. On dialysis days, administer after dialysis as early as possible. No nondialysis regimen below CrCl 15 is established. Recheck changing CrCl at least daily. Abdominal infection also requires metronidazole. This May 2022 mirror does not contain the pediatric renal regimens added to the separately stored May 2026 label.

Adults: cUTI/cIAI baseline 1.5 g IV every 8 hours; CrCl 30-50, 750 mg every 8 hours; 15-29, 375 mg every 8 hours; HD, 750 mg load then 150 mg every 8 hours.

HAP/VAP or septic shock: baseline 3 g every 8 hours; 30-50, 1.5 g every 8 hours; 15-29, 750 mg every 8 hours; HD, 2.25 g load then 450 mg every 8 hours. Inpatient infusions run over 4 hours, unlike the label's 1 hour. Only the adult rows are summarized.