Official source
Ceftobiprole medocaril sodium (Zevtera, adult IV) - selected U.S. label sections
- Product / population
- U.S. ZEVTERA IV prodrug doses: 667 mg ceftobiprole medocaril sodium is equivalent to 500 mg ceftobiprole; 333 mg is equivalent to 250 mg. Not an international 500 mg vial instruction.
- Renal measure
- Creatinine clearance in mL/min; adult U.S. product table
Selected renal sections only, not a complete monograph. Exact product, indication, patient population, renal method and all other contraindications/interactions remain controlling.
Second independent renal reference and clinician adjudication remain pending; no all-indication, dialysis or pediatric dose may be inferred from an omitted field.
Adult renal table - U.S. prodrug dose units
| CrCl | S. aureus bacteremia | ABSSSI or community-acquired bacterial pneumonia |
|---|---|---|
| 30 to below 50 | 667 mg every 8 hours on days 1-8, then every 12 hours | 667 mg every 12 hours |
| 15 to below 30 | 333 mg every 8 hours on days 1-8, then every 12 hours | 333 mg every 12 hours |
| Below 15, including hemodialysis | 333 mg every 24 hours | 333 mg every 24 hours |
Administer each dose by a 2-hour IV infusion. On hemodialysis days, administer after dialysis.
Augmented renal clearance
For adult CrCl above 150 mL/min, the label specifies 667 mg every 6 hours. This is not a pediatric schedule.
Source: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2bd685df-7dc6-78a6-e063-6294a90a580b