UCSF - AVYCAZ extended-infusion protocol
- Product / population
- Adults; IV ceftazidime/avibactam combined dose; ID/antimicrobial-stewardship restricted.
- Renal measure
- CrCl in mL/min where specified; no equation inferred.
- Source revision
- Revision date not stated in the reviewed page.
- Retrieved
- 2026-09-05 (not the revision date)
The website writes <5 rather than <=5. Exact-boundary ambiguity is retained.
Dosing / renal protocol and limits
The columns omit exactly 5. All these institutional infusions last 3 hours; do not silently substitute the product-label infusion duration.
| CrCl, mL/min | Source-specific dose / instruction |
|---|---|
| >50 | 2.5 g every 8 hours |
| 31-50 | 1.25 g every 8 hours |
| 16-30 | 0.94 g every 12 hours |
| 6-15 | 0.94 g every 24 hours |
| <5 | 0.94 g every 48 hours |
Dialysis guidance - separate source-specific schedules
| Dialysis setting / indication | Source-specific schedule |
|---|---|
| IHD | 0.94 g initially, then each evening |
| IHD alternative - minimal residual function and less severe infection | 0.94 g every 48 hours in the evening |
| CVVHD | 2.5 g every 8 hours |
Read the retained text before reformatting
Doses refer to the combined product and are infused IV over 3 hours. CrCl columns as published (>50 / 31-50 / 16-30 / 6-15 / <5 mL/min) correspond to 2.5 g every 8 hours / 1.25 g every 8 hours / 0.94 g every 12 hours / 0.94 g daily / 0.94 g every 48 hours.
The published columns omit exactly 5 mL/min; that boundary is not repaired by assumption.
IHD: 0.94 g initially, then each evening. For minimal residual kidney function and less severe infection, an alternative is 0.94 g every 48 hours in the evening. CVVHD: 2.5 g every 8 hours. All these institutional infusions last 3 hours; retain separately from product-label infusion instructions.
Source: https://idmp.ucsf.edu/content/ceftazidime-avibactam-avycaz