Original GlobalRPh source
- Product / population
- Preserved GlobalRPh source, not a freshly verified product label
- Renal measure
- Use the method specified in the original source
- Source revision
- Historical source; revision not established here
- Retrieved
- 2026-09-05 (not the revision date)
Historical source: not automatically current. Review current official labeling and separately attributed additions before use.
Usual Dosing (Adults)
Usual: 1 to 2 grams IV every 8 to 12 hours. Severe: 2 grams IV every 8 hours.
Source dosing table:
| Indication | Dose | Interval |
|---|---|---|
| Usual adult | 1 g IV/IM | Every 8 to 12 hours |
| Uncomplicated urinary tract | 250 mg IV/IM | Every 12 hours |
| Bone and joint | 2 g IV | Every 12 hours |
| Complicated urinary tract | 500 mg IV/IM | Every 8 to 12 hours |
| Uncomplicated pneumonia or mild skin/skin structure | 500 mg to 1 g IV/IM | Every 8 hours |
| Serious gynecologic or intra-abdominal | 2 g IV | Every 8 hours |
| Meningitis | 2 g IV | Every 8 hours |
| Very severe life-threatening infections, especially immunocompromised | 2 g IV | Every 8 hours |
| Cystic fibrosis lung infection due to Pseudomonas with normal renal function | 30 to 50 mg/kg IV; maximum 6 g/day | Every 8 hours |
| Neonates 0 to 4 weeks | 30 mg/kg IV | Every 12 hours |
| Infants and children 1 month to 12 years | 30 to 50 mg/kg IV; maximum 6 g/day | Every 8 hours |
The higher pediatric dose is for immunocompromised patients, cystic fibrosis, or meningitis. In cystic fibrosis patients clinical improvement has occurred, but bacteriologic cures cannot be expected in chronic respiratory disease and cystic fibrosis.
Renal Dosing
| CrCl (mL/min) | Dose |
|---|---|
| >50 | No change |
| 31 to 50 | 1 g every 12 hours |
| 16 to 30 | 1 g every 24 hours |
| 6 to 15 | 500 mg every 24 hours |
| <5 or dialysis | 500 mg every 48 hours |
All renal doses may be increased by 50% in severe infections, as stated in the source.
Hemodialysis
1 g loading dose, then 1 g after each hemodialysis session. Alternative: 1 g every 48 hours plus 1 g after each hemodialysis.
CAPD: 1 g once, then 500 mg every 24 hours.
