Ceftazidime

Reduce maintenance dosing for impaired renal elimination. Select dose and interval using the adult renal table, the infection severity, and the organism's susceptibility. Excess exposure may cause encephalopathy, myoclonus or seizures. Verify the relevant dialysis schedule separately.

Adjust ceftazidime maintenance for impaired clearance. Match the schedule to kidney function, infection severity, and organism susceptibility. High concentrations during reduced urine output can cause neurologic toxicity. Verify the indication and dialysis modality.

The mirror warns of neurotoxicity from high concentrations when usual dosing continues during renal impairment.

The mirror directs a lower total daily dose in renal insufficiency and describes neurologic toxicity with excess exposure.

Short-infusion IV dosing by CrCl: >50, 2 g every 8 hours; 31-50, 2 g every 12 hours; 15-30, 2 g daily; <15, 1 g daily.

IHD: 1 g initially and following each dialysis. CVVHD: 2 g every 12 hours.

A separate specialist-selected extended-infusion strategy uses 2 g over 30 minutes as loading, then maintenance beginning 4 hours later. Maintenance infusions last 4 hours: 2 g every 8 hours above CrCl 50 or every 12 hours at 31-50. Below 31, use short infusion. CVVHD extended infusion also requires ID/pharmacy selection.