GlobalRPh Renal Dosing Masterv6.6
GlobalRPh source record

Ceftaroline (Teflaro)

GlobalRPh source pageBase record retrieved 2026-09-05See the evidence for this drug2 sources available - open source summaries, references and comparisons
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Professional source

UCSF - ceftaroline: standard and severe-infection schedules

Product / population
Adults; source-specific institutional guidance. Match route, indication and renal replacement modality.
Renal measure
CrCl in mL/min where specified; no equation inferred.

Dosing / renal protocol and limits

Limits that apply to these rows

Printed bands overlap at 30. Higher-frequency dosing is institutional. Some serious infections with CrCl <50 or IHD may instead use every-12-hour dosing after ID pharmacy review.

Skin infection or CAP with low MRSA risk - IV
CrCl, mL/minSource-specific dose / instruction
>50600 mg every 12 hours
30-50400 mg every 12 hours
15-30300 mg every 12 hours
<15200 mg every 12 hours
Severe infection / suspected or documented MRSA pneumonia - IV
CrCl, mL/minSource-specific dose / instruction
>50600 mg every 8 hours
30-50400 mg every 8 hours
15-30300 mg every 8 hours
<15200 mg every 8 hours
Dialysis guidance - separate source-specific schedules
Ceftaroline - dialysis
Dialysis setting / indicationSource-specific schedule
IHD - first indication group200 mg every 12 hours
IHD - severe infection200 mg every 8 hours
Continuous HD - first indication group400 mg every 12 hours
Continuous HD - severe infection600 mg every 12 hours
Read the retained text before reformatting

CrCl bands >50 / 30-50 / 15-30 / <15 mL/min correspond to IV doses 600 / 400 / 300 / 200 mg. For skin infection or community-acquired pneumonia with low MRSA risk, give every 12 hours. For severe infection or pneumonia with suspected/documented MRSA, this institutional regimen uses every 8 hours. The source overlaps at 30.

Intermittent HD: 200 mg every 12 hours for the first group or every 8 hours for severe infection. Continuous HD: 400 mg every 12 hours for the first group or 600 mg every 12 hours for severe infection. Some serious infections with CrCl <50 or IHD may use every-12-hour dosing after ID pharmacy review. The higher-frequency strategy is source-specific.

Source revision: Revision date not stated in the reviewed page. | Retrieved: 2026-09-05. Retrieval date is not the revision date.

Source: https://idmp.ucsf.edu/content/ceftaroline

Scope: Locally included source-specific summary. Regimen differences are not automatically resolved. GlobalRPh v6.6.

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Evidence sources and renal implications

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Preserved historical content; not revalidated as current prescribing guidance.

Renal method: Read the measure and population stated in the original source sections.
Retrieved: 2026-09-05

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Professional guidance

UCSF - ceftaroline: standard and severe-infection schedules

Adults; source-specific institutional guidance. Match route, indication and renal replacement modality.

Renal method: CrCl in mL/min where specified; no equation inferred.
Retrieved: 2026-09-05

Read local renal resultOpen original reference

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Renal dosing and precautions

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Original content / product scopeUCSF - ceftaroline: standard and severe-infection schedules
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Historical source content is not a current prescription. Original GlobalRPh recommendations are preserved, not automatically certified as current. Product-label and professional additions below are separately attributed. Confirm indication, population, kidney-function method, monitoring and the full prescribing information before applying a regimen.
Locally stored source content

Original GlobalRPh protocol

Clinical facts and comments transcribed into a structured reading format. This is not a byte-for-byte HTML archive. Original source: https://globalrph.com/renal/ceftaroline/

Indications and usage

Teflaro (ceftaroline fosamil) is indicated for acute bacterial skin and skin structure infections (ABSSSI) caused by susceptible S. aureus (including methicillin-susceptible and methicillin-resistant isolates), S. pyogenes, S. agalactiae, E. coli, K. pneumoniae and K. oxytoca.

Community-acquired bacterial pneumonia (CABP): S. pneumoniae (including concurrent bacteremia), S. aureus (methicillin-susceptible isolates only), H. influenzae, K. pneumoniae, K. oxytoca and E. coli.

Use only for proven or strongly suspected susceptible bacterial ABSSSI or CABP. Obtain appropriate specimens to isolate and identify causative organisms and determine susceptibility. When available, culture and susceptibility information should guide selection or modification; otherwise local epidemiology and susceptibility patterns may contribute.

GRPH-ceftaroline-01 · Source section: Indications and usageRenal section finder

Usual Dosing (Adults)

Adults >=18 years: 600 mg IV every 12 hours, infused over 1 hour. Duration is guided by severity/site and clinical and bacteriological progress: ABSSSI 5 to 14 days; CABP 5 to 7 days.

GRPH-ceftaroline-02 · Source section: Usual Dosing (Adults)Renal section finder

Renal Dosing

Cockcroft-Gault creatinine clearance:

CrCl (mL/min)Dose
>50No adjustment
>30 to <=50400 mg IV over 1 hour every 12 hours
>=15 to <=30300 mg IV over 1 hour every 12 hours
ESRD <15, including hemodialysis200 mg IV over 1 hour every 12 hours
GRPH-ceftaroline-03 · Source section: Renal DosingRenal section finder

Hemodialysis

Teflaro is hemodialyzable. Administer after hemodialysis on dialysis days.

GRPH-ceftaroline-04 · Source section: HemodialysisRenal section finder
Separate professional-source layer

University and professional protocols

Professional

UCSF - ceftaroline: standard and severe-infection schedules

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UCSF Infectious Diseases Management Program · Adults; source-specific institutional guidance. Match route, indication and renal replacement modality.

Renal method: CrCl in mL/min where specified; no equation inferred.
Source date: Revision date not stated in the reviewed page.
Retrieved: 2026-09-05

Locally included source-specific summary. Regimen differences are not automatically resolved.

Dosing / renal protocol and limits

Limits that apply to these rows

Printed bands overlap at 30. Higher-frequency dosing is institutional. Some serious infections with CrCl <50 or IHD may instead use every-12-hour dosing after ID pharmacy review.

Skin infection or CAP with low MRSA risk - IV
CrCl, mL/minSource-specific dose / instruction
>50600 mg every 12 hours
30-50400 mg every 12 hours
15-30300 mg every 12 hours
<15200 mg every 12 hours
Severe infection / suspected or documented MRSA pneumonia - IV
CrCl, mL/minSource-specific dose / instruction
>50600 mg every 8 hours
30-50400 mg every 8 hours
15-30300 mg every 8 hours
<15200 mg every 8 hours
Dialysis guidance - separate source-specific schedules
Ceftaroline - dialysis
Dialysis setting / indicationSource-specific schedule
IHD - first indication group200 mg every 12 hours
IHD - severe infection200 mg every 8 hours
Continuous HD - first indication group400 mg every 12 hours
Continuous HD - severe infection600 mg every 12 hours
Read the retained text before reformatting

CrCl bands >50 / 30-50 / 15-30 / <15 mL/min correspond to IV doses 600 / 400 / 300 / 200 mg. For skin infection or community-acquired pneumonia with low MRSA risk, give every 12 hours. For severe infection or pneumonia with suspected/documented MRSA, this institutional regimen uses every 8 hours. The source overlaps at 30.

Intermittent HD: 200 mg every 12 hours for the first group or every 8 hours for severe infection. Continuous HD: 400 mg every 12 hours for the first group or 600 mg every 12 hours for severe infection. Some serious infections with CrCl <50 or IHD may use every-12-hour dosing after ID pharmacy review. The higher-frequency strategy is source-specific.

RDM30-041-ceftaroline-1 · Source locator: UCSF - ceftaroline: standard and severe-infection schedules; renal/dosing sections and stated qualifiers

Source identity and provenance
Source
https://idmp.ucsf.edu/content/ceftaroline
Retrieved
2026-09-05
Renal-function method
CrCl in mL/min where specified; no equation inferred.
Source date/version
Revision date not stated in the reviewed page.
Hash meaning
Locally authored summary text; not original SPL, HTML or PDF bytes
Local summary SHA-256
94f03f3b747f167199b2721687b95102008fc4b89f5cec0da6885c0d6f497b1b

Provenance and preservation

Additional summaries stored on this page: 0 official-label, 0 RX List, 1 professional, 0 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source
https://globalrph.com/renal/ceftaroline/
Source retrieval
2026-09-05. This is not the source publication or label revision date.
Original source type
globalrph individual
Local text SHA-256
7e3b6ca10768863016fb9e9ebb538bee2daab5bb8a7ccc96a133991b901aaadd
Import versus clinical validation
Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

The original individual GlobalRPh pages commonly cite NIH/NLM DailyMed and instruct readers to review the applicable package insert for updates. That historical reference is preserved as context; it is not counted as an independently retrieved current label.

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