Cefotetan | GlobalRPh Renal Dosing Master

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Historical source

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Usual Dosing (Adults)

1 to 2 grams every 12 hours; life-threatening infections: 3 grams IV every 12 hours. Maximum 6 g/day.

Source dosing table:

Site/severity	Total daily dose	Schedule
Urinary tract	1 to 4 g	500 mg every 12 hours IV/IM; or 1 or 2 g every 24 hours IV/IM; or 1 or 2 g every 12 hours IV/IM
Mild to moderate skin and skin structure	2 g	2 g every 24 hours IV, or 1 g every 12 hours IV/IM
Severe skin and skin structure	4 g	2 g every 12 hours IV
Other sites, mild to moderate	2 to 4 g	1 or 2 g every 12 hours IV/IM
Other sites, severe	4 g	2 g every 12 hours IV
Life-threatening infections	6 g	3 g every 12 hours IV

For K. pneumoniae skin infections, the source specifies 1 or 2 g every 12 hours IV/IM. If C. trachomatis is suspected in gynecologic infections, add anti-chlamydial coverage; cefotetan has no activity against it.

Prophylaxis for clean-contaminated or potentially contaminated surgery in adults: 1 or 2 g IV once 30 to 60 minutes before surgery; for cesarean section, give as soon as the cord is clamped.

Renal Dosing

CrCl (mL/min)	Dose
>30	No change
10 to 30	1 to 2 g every 24 hours or 0.5 to 1 g every 12 hours
<10	1 to 2 g every 48 hours or 250 to 500 mg every 12 hours

Hemodialysis

250 to 500 mg every 24 hours on non-dialysis days; 500 mg to 1 g every 24 hours on dialysis days.

Peritoneal dialysis: 1 g every 24 hours.

Source revision: Historical source; revision not established here | Retrieved: 2026-09-05. Retrieval date is not the revision date.

Source: https://globalrph.com/renal/cefotetan/

Scope: Preserved historical source; no fresh clinical approval GlobalRPh v6.6.

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Retrieved: 2026-09-05

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Method: Use the measure stated in the original section.

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Original GlobalRPh protocol

Clinical facts and comments transcribed into a structured reading format. This is not a byte-for-byte HTML archive. Original source: https://globalrph.com/renal/cefotetan/

Usual Dosing (Adults)

1 to 2 grams every 12 hours; life-threatening infections: 3 grams IV every 12 hours. Maximum 6 g/day.

Source dosing table:

Site/severity	Total daily dose	Schedule
Urinary tract	1 to 4 g	500 mg every 12 hours IV/IM; or 1 or 2 g every 24 hours IV/IM; or 1 or 2 g every 12 hours IV/IM
Mild to moderate skin and skin structure	2 g	2 g every 24 hours IV, or 1 g every 12 hours IV/IM
Severe skin and skin structure	4 g	2 g every 12 hours IV
Other sites, mild to moderate	2 to 4 g	1 or 2 g every 12 hours IV/IM
Other sites, severe	4 g	2 g every 12 hours IV
Life-threatening infections	6 g	3 g every 12 hours IV

Prophylaxis for clean-contaminated or potentially contaminated surgery in adults: 1 or 2 g IV once 30 to 60 minutes before surgery; for cesarean section, give as soon as the cord is clamped.

GRPH-cefotetan-01 · Source section: Usual Dosing (Adults)Renal section finder

Renal Dosing

CrCl (mL/min)	Dose
>30	No change
10 to 30	1 to 2 g every 24 hours or 0.5 to 1 g every 12 hours
<10	1 to 2 g every 48 hours or 250 to 500 mg every 12 hours

GRPH-cefotetan-02 · Source section: Renal DosingRenal section finder

Hemodialysis

250 to 500 mg every 24 hours on non-dialysis days; 500 mg to 1 g every 24 hours on dialysis days.

Peritoneal dialysis: 1 g every 24 hours.

GRPH-cefotetan-03 · Source section: HemodialysisRenal section finder

Provenance and preservation

Additional summaries stored on this page: 0 official-label, 0 RX List, 0 professional, 0 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source: https://globalrph.com/renal/cefotetan/
Source retrieval: 2026-09-05. This is not the source publication or label revision date.
Original source type: globalrph individual
Local text SHA-256: a5e687a9b25dc53b76c1c4bf852ee7b21cf46c51fe0be4e5fd1aa4750f5e4057
Import versus clinical validation: Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

The original individual GlobalRPh pages commonly cite NIH/NLM DailyMed and instruct readers to review the applicable package insert for updates. That historical reference is preserved as context; it is not counted as an independently retrieved current label.

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