GlobalRPh Renal Dosing Masterv6.6
Evidence addition

Carvedilol immediate-release

Local official-label summaryBase record retrieved 2026-09-05See the evidence for this drug2 sources available - open source summaries, references and comparisons
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Official source

Carvedilol immediate-release - titration and renal monitoring

Product / population
Adults; named product and route only. Selected dosing and renal summary, not the full prescribing information.
Renal measure
No renal-function dose bands specified for this summary.

Dosing / renal protocol and limits

Adult heart failure: 3.125 mg orally twice daily for 2 weeks, then, if tolerated, 6.25, 12.5 and 25 mg twice daily at intervals of at least 2 weeks. For hypertension, begin 6.25 mg twice daily and titrate at 1-2-week intervals, to at most 25 mg twice daily.

No fixed CrCl reduction schedule is supplied in this label. During titration, monitor renal function particularly with low blood pressure, ischemic/vascular disease or underlying renal impairment. Reduce or discontinue if renal function worsens. Carvedilol is not significantly cleared by HD. These are immediate-release tablets, not extended-release capsules.

Source revision: Selected label updated 2024-06-07; revised August 2023. | Retrieved: 2026-09-05. Retrieval date is not the revision date.

Source: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=7cc14b86-0833-4c3c-91f3-7963d7052fd5

Scope: Locally included source-specific summary. Regimen differences are not automatically resolved. GlobalRPh v6.6.

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Evidence sources and renal implications

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Official product label

Carvedilol immediate-release - titration and renal monitoring

Adults; named product and route only. Selected dosing and renal summary, not the full prescribing information.

Renal method: No renal-function dose bands specified for this summary.
Retrieved: 2026-09-05

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Handbook

Renal Drug Handbook, 5th edition - Carvedilol

Historical adult renal/RRT summary. U.S. product identity anchored to the separate locally included DailyMed label. This is not a current U.S. product label.

Renal method: Book table headed GFR (mL/min); its preface states renal adjustments generally derive from Cockcroft-Gault CrCl. Do not silently relabel as indexed eGFR.
Retrieved: 2026-09-05

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Renal dosing and precautions

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Handbook source

Renal Drug Handbook, 5th edition - Carvedilol

Historical adult renal/RRT summary. U.S. product identity anchored to the separate locally included DailyMed label. This is not a current U.S. product label.

Method: Book table headed GFR (mL/min); its preface states renal adjustments generally derive from Cockcroft-Gault CrCl. Do not silently relabel as indexed eGFR.

Historical renal / replacement-therapy guidanceRead this complete source summary

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Original content / product scopeCarvedilol immediate-release - titration and renal monitoringRenal Drug Handbook, 5th edition - Carvedilol
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Exact product and population matter. This added page contains locally stored, source-specific clinical summaries. Historical handbook information, when present, is identified separately and may conflict with U.S. labeling. Confirm indication, population, kidney-function method, monitoring and the full prescribing information before applying a regimen.
Locally stored source content

Exact product and population

Product identity selected for the separately displayed source protocols below. Reference: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=7cc14b86-0833-4c3c-91f3-7963d7052fd5

Product and population scope

Adult Carvedilol immediate-release. Use only the product, route, indication and renal-replacement setting explicitly stated in the source protocol selected below. Sources are alternatives to compare, not ingredients of a blended regimen.

SCOPE-carvedilol-ir · Source section: Editorial scope; each clinical recommendation is separately attributed belowRenal section finder
Separate U.S. product-label layer

FDA / DailyMed dosing and renal information

Official

Carvedilol immediate-release - titration and renal monitoring

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NIH/NLM DailyMed - U.S. product labeling · Adults; named product and route only. Selected dosing and renal summary, not the full prescribing information.

Renal method: No renal-function dose bands specified for this summary.
Source date: Selected label updated 2024-06-07; revised August 2023.
Retrieved: 2026-09-05

Locally included source-specific summary. Regimen differences are not automatically resolved.

Dosing / renal protocol and limits

Adult heart failure: 3.125 mg orally twice daily for 2 weeks, then, if tolerated, 6.25, 12.5 and 25 mg twice daily at intervals of at least 2 weeks. For hypertension, begin 6.25 mg twice daily and titrate at 1-2-week intervals, to at most 25 mg twice daily.

No fixed CrCl reduction schedule is supplied in this label. During titration, monitor renal function particularly with low blood pressure, ischemic/vascular disease or underlying renal impairment. Reduce or discontinue if renal function worsens. Carvedilol is not significantly cleared by HD. These are immediate-release tablets, not extended-release capsules.

RDM30-081-carvedilol-ir-1 · Source locator: Carvedilol immediate-release - titration and renal monitoring; renal/dosing sections and stated qualifiers

Source identity and provenance
Source
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=7cc14b86-0833-4c3c-91f3-7963d7052fd5
Retrieved
2026-09-05
DailyMed Set ID
7cc14b86-0833-4c3c-91f3-7963d7052fd5
Renal-function method
No renal-function dose bands specified for this summary.
Source date/version
Selected label updated 2024-06-07; revised August 2023.
Hash meaning
Locally authored summary text; not original SPL, HTML or PDF bytes
Local summary SHA-256
a7b8907d37d189f0c77e2b44db79bd1d7c10ac6948ce4b2d63ff32e22a38d30a
Separate handbook layer

Renal Drug Handbook cross-check

Handbook

Renal Drug Handbook, 5th edition - Carvedilol

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UK Renal Pharmacy Group / CRC Press · Historical adult renal/RRT summary. U.S. product identity anchored to the separate locally included DailyMed label. This is not a current U.S. product label.

Renal method: Book table headed GFR (mL/min); its preface states renal adjustments generally derive from Cockcroft-Gault CrCl. Do not silently relabel as indexed eGFR.
Source date: 5th edition; 2019 copyright; historical reference
Retrieved: 2026-09-05

Historical handbook cross-check; not a current U.S. protocol

Historical renal / replacement-therapy guidance

The 20-50, 10-20 and <10 mL/min bands retain the usual indication-specific dose. For renal replacement therapy, start low and titrate to response. HD removal is described as absent; PD/continuous removal unlikely; high-flux removal unknown. The book includes broader indication dose ranges; this page uses the separate U.S. immediate-release label for baseline titration.

HB30-carvedilol-ir-1 · Source locator: Printed page 174: renal impairment, RRT and other information

Source-specific limits

Separate source recommendation, not proof of agreement or contemporary clinical validation. Dialysis predictions are retained with their original certainty.

Source identity and provenance
Retrieved
2026-09-05
Handbook page
5th edition, printed p. 174; uploaded PDF p. 193
Renal-function method
Book table headed GFR (mL/min); its preface states renal adjustments generally derive from Cockcroft-Gault CrCl. Do not silently relabel as indexed eGFR.
Source date/version
5th edition; 2019 copyright; historical reference
U.S. product identity basis
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=7cc14b86-0833-4c3c-91f3-7963d7052fd5
Hash meaning
Local paraphrase; original book not redistributed
Local summary SHA-256
9fd88e4e24ecb98f63e566eb61862620c6306cdfbbc8f8752c88761bd549e1c3

Provenance and preservation

Additional summaries stored on this page: 1 official-label, 0 RX List, 0 professional, 1 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=7cc14b86-0833-4c3c-91f3-7963d7052fd5
Source retrieval
2026-09-05. This is not the source publication or label revision date.
Original source type
multisource addition
Local text SHA-256
f75ed1790dbfeb257ae2a231dc8ecc7afe4371cf1d444f7d4cb1e612b12ea4e4
Import versus clinical validation
Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

This page is an additional exact-product entry, not a recovered GlobalRPh monograph. Its primary scope text and separately attributed clinical summaries are locally included.

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