Bupropion sustained-release for smoking cessation (ZYBAN)

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The numeric every-other-day maximum is hepatic, not renal

The RX renal paragraph gives a qualitative reduction instruction, while the adjacent hepatic paragraph gives a numeric maximum. The repeated page sections also carry different revision dates.

Before applying: Do not promote the hepatic schedule into an evidence-based renal table. Reconcile the current exact smoking-cessation product label and monitor adverse effects.

Also check: The numeric every-other-day maximum is hepatic, not renal

Rxlist source

GlobalRPh RX List - ZYBAN

Product / population: ZYBAN oral sustained-release smoking-cessation product; not a substituted XL regimen.
Renal measure: GFR printed as mL/min; no indexed denominator stated.

RX mirror: this is not independent corroboration of its underlying label. Check dated-label and formulation limitations.

Renal dosing, restrictions and evidence limits

At GFR below 90 mL/min, consider reducing the dose, dosing frequency, or both. Bupropion and metabolites may accumulate; monitor for adverse effects suggesting excessive exposure. No specific renal reduction schedule is provided. The nearby 150 mg every-other-day maximum is a hepatic instruction, not the renal algorithm. The page repeats dosage material with different revision dates, so confirm the current exact product label before prescribing.

Source revision: Mixed page sections marked June 2016 and July 2019 | Retrieved: 2026-09-07. Retrieval date is not the revision date.

Source: https://globalrph.com/rx-list/zyban-drug/

Scope: Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph. GlobalRPh v6.6.

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GlobalRPh RX List

GlobalRPh RX List - ZYBAN

Qualitative renal precaution. No complete numerical renal schedule is supplied by this selected finding.

ZYBAN oral sustained-release smoking-cessation product; not a substituted XL regimen.

Renal method: GFR printed as mL/min; no indexed denominator stated.
Retrieved: 2026-09-07

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organ specific instruction

The numeric every-other-day maximum is hepatic, not renal

The RX renal paragraph gives a qualitative reduction instruction, while the adjacent hepatic paragraph gives a numeric maximum. The repeated page sections also carry different revision dates.

How to use this: Do not promote the hepatic schedule into an evidence-based renal table. Reconcile the current exact smoking-cessation product label and monitor adverse effects.

GlobalRPh RX List - ZYBAN

Source-specific interpretation; independent clinician adjudication pending.

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Renal dosing and precautions

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Rxlist source

GlobalRPh RX List - ZYBAN

ZYBAN oral sustained-release smoking-cessation product; not a substituted XL regimen.

Method: GFR printed as mL/min; no indexed denominator stated.

Renal dosing, restrictions and evidence limits Read this complete source summary

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Original content / product scope GlobalRPh RX List - ZYBAN

Exact product and population matter. This added page contains locally stored, source-specific clinical summaries. Historical handbook information, when present, is identified separately and may conflict with U.S. labeling. Confirm indication, population, kidney-function method, monitoring and the full prescribing information before applying a regimen.

Locally stored source content

Exact product and population

Product identity selected for the separately displayed source protocols below. Reference: https://globalrph.com/rx-list/zyban-drug/

Exact product and population

ZYBAN oral sustained-release smoking-cessation product; not a substituted XL regimen.

RDM37-SCOPE-bupropion-zyban-smoking-cessation · Source section: Selected source product scopeRenal section finder

Locally imported selected renal sections

GlobalRPh RX List renal information

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GlobalRPh RX List - ZYBAN

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GlobalRPh-hosted RX List · ZYBAN oral sustained-release smoking-cessation product; not a substituted XL regimen.

Renal method: GFR printed as mL/min; no indexed denominator stated.
Source date: Mixed page sections marked June 2016 and July 2019
Retrieved: 2026-09-07

Label mirror, not independent corroboration. This is selected locally stored RX List content. Full monograph import and current official-label review are not implied.

Qualitative renal precaution. No complete numerical renal schedule is supplied by this selected finding.

Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph.

Renal dosing, restrictions and evidence limits

RDM37-rxlist-bupropion-zyban-smoking-cessation-f25ade7cb3-C1 · Source locator: Dosage: Renal versus Hepatic Impairment; repeated dosage section.

Source identity and provenance

Source family: product_label_mirror
Source: https://globalrph.com/rx-list/zyban-drug/
Retrieved: 2026-09-07
Renal-function method: GFR printed as mL/min; no indexed denominator stated.
Source date/version: Mixed page sections marked June 2016 and July 2019
Hash meaning: SHA-256 of local authored summary only; not original HTML, PDF or SPL bytes.
Local summary SHA-256: 85ad31ff9457ab827ce08c3b792e6f236fc8587e7cb6b1090544edbf463adbb7

Provenance and preservation

Additional summaries stored on this page: 0 official-label, 1 RX List, 0 professional, 0 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source: https://globalrph.com/rx-list/zyban-drug/
Source retrieval: 2026-09-07. This is not the source publication or label revision date.
Original source type: rxlist summary
Local text SHA-256: 7d1d9aba6d9ada4d9d428b13abf2594a365edb00b9f163297bd1220f7f1852b2
Import versus clinical validation: Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

This page is an additional exact-product entry, not a recovered GlobalRPh monograph. Its primary scope text and separately attributed clinical summaries are locally included.

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