GlobalRPh Renal Dosing Masterv6.6
Evidence addition

Bosutinib (BOSULIF), adults

Local RX List renal extractBase record retrieved 2026-09-07See the evidence for this drug1 sources available - open source summaries, references and comparisons

Bosulif

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Rxlist source

GlobalRPh RX List - Bosulif

Product / population
Adult starting doses only. Separate pediatric tables and subsequent toxicity modifications are outside this local extract.
Renal measure
CrCl by Cockcroft-Gault, mL/min.

RX mirror: this is not independent corroboration of its underlying label. Check dated-label and formulation limitations.

Renal dosing, restrictions and evidence limits

For CrCl 30 to 50 mL/min, the adult starting dose is 300 mg once daily for newly diagnosed chronic-phase CML, or 400 mg once daily for previously treated resistant/intolerant disease. For CrCl below 30 mL/min, the corresponding doses are 200 mg and 300 mg once daily. The reference starting doses without renal or hepatic impairment are 400 mg and 500 mg once daily, respectively. Hemodialysis has not been studied. Monitor renal function and use the full label for subsequent toxicity-related changes.

Source revision: Revised December 2024 on retrieved RX List page | Retrieved: 2026-09-07. Retrieval date is not the revision date.

Source: https://globalrph.com/rx-list/bosulif-drug/

Scope: Locally imported selected source sections; independent clinical review pending. Not a complete prescribing monograph. GlobalRPh v6.6.

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Evidence sources and renal implications

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GlobalRPh RX List

GlobalRPh RX List - Bosulif

Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.

Adult starting doses only. Separate pediatric tables and subsequent toxicity modifications are outside this local extract.

Renal method: CrCl by Cockcroft-Gault, mL/min.
Retrieved: 2026-09-07

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Renal dosing and precautions

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New source summary - independent clinical review pending. Summaries of the identified label sections are included locally. Source import and numeric transcription checks are not independent two-reference validation. Do not treat this card as an approved institutional dosing protocol.

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Original content / product scopeGlobalRPh RX List - Bosulif
Exact product and population matter. This added page contains locally stored, source-specific clinical summaries. Historical handbook information, when present, is identified separately and may conflict with U.S. labeling. Confirm indication, population, kidney-function method, monitoring and the full prescribing information before applying a regimen.
Locally stored source content

Exact product and population

Product identity selected for the separately displayed source protocols below. Reference: https://globalrph.com/rx-list/bosulif-drug/

Product and population scope

Adult starting doses only. Separate pediatric tables and subsequent toxicity modifications are outside this local extract.

RDM33-SCOPE-bosutinib-bosulif-C1 · Source section: Exact product identity and selected populationRenal section finder
Locally imported selected renal sections

GlobalRPh RX List renal information

Rxlist

GlobalRPh RX List - Bosulif

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GlobalRPh-hosted RX List · Adult starting doses only. Separate pediatric tables and subsequent toxicity modifications are outside this local extract.

Renal method: CrCl by Cockcroft-Gault, mL/min.
Source date: Revised December 2024 on retrieved RX List page
Retrieved: 2026-09-07

Label mirror, not independent corroboration. This is selected locally stored RX List content. Full monograph import and current official-label review are not implied.
Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.

Locally imported selected source sections; independent clinical review pending. Not a complete prescribing monograph.

Renal dosing, restrictions and evidence limits

For CrCl 30 to 50 mL/min, the adult starting dose is 300 mg once daily for newly diagnosed chronic-phase CML, or 400 mg once daily for previously treated resistant/intolerant disease. For CrCl below 30 mL/min, the corresponding doses are 200 mg and 300 mg once daily. The reference starting doses without renal or hepatic impairment are 400 mg and 500 mg once daily, respectively. Hemodialysis has not been studied. Monitor renal function and use the full label for subsequent toxicity-related changes.

RDM33-rxlist-bosutinib-bosulif-C1 · Source locator: Dosage and administration: Table 4, adult renal/hepatic starting-dose adjustments; renal impairment.

Source identity and provenance
Source family
product_label_mirror
Source
https://globalrph.com/rx-list/bosulif-drug/
Retrieved
2026-09-07
Renal-function method
CrCl by Cockcroft-Gault, mL/min.
Source date/version
Revised December 2024 on retrieved RX List page
Hash meaning
SHA-256 of the local authored summary only; original HTML/PDF/SPL bytes are not bundled or hashed.
Local summary SHA-256
b8d2f0ef6dee843b21130ad1bc0d9de59ddcef3de49f3a6e609d7ac6acd18140

Provenance and preservation

Additional summaries stored on this page: 0 official-label, 1 RX List, 0 professional, 0 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source
https://globalrph.com/rx-list/bosulif-drug/
Source retrieval
2026-09-07. This is not the source publication or label revision date.
Original source type
rxlist summary
Local text SHA-256
2eb7daff1843d4b6e8e74a06c369164435ea6bc3335a18eb8b5d105861484378
Import versus clinical validation
Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

This page is an additional exact-product entry, not a recovered GlobalRPh monograph. Its primary scope text and separately attributed clinical summaries are locally included.

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