GlobalRPh Renal Dosing Masterv6.6
GlobalRPh source record

Bivalirudin

GlobalRPh source pageBase record retrieved 2026-09-05See the evidence for this drug1 sources available - open source summaries, references and comparisons

Angiomax

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Usual Dosing (Adults)

Dosing and Administration

For patients who do not have HIT/HITTS: PCI/PTCA: 0.75 mg/kg intravenous (IV) bolus dose followed by a 1.75 mg/kg/h IV infusion for the duration of the procedure. Perform activated clotting time (ACT) test 5 minutes post-bolus dose. If needed, give an additional bolus of 0.3 mg/kg. After PCI/PTCA, IV infusion may be continued for up to 4 hours, after which a rate of 0.2 mg/kg/h can be used for up to 20 more hours, if needed.

Consider glycoprotein IIb/IIIa inhibitor (GPI) administration with procedural complications.

For patients who have HIT/HITTS: The recommended dose of Angiomax in patients with HIT/HITTS undergoing PCI is an IV bolus of 0.75 mg/kg. This should be followed by an infusion at a rate of 1.75 mg/kg/h for the duration of the procedure. After PCI/PTCA, IV infusion may be continued for up to 4 hours, after which a rate of 0.2 mg/kg/h can be used for up to 20 more hours, if needed.

For patients with Renal Impairment: No reduction in bolus dose required. Consider reduction of the rate of infusion to 1 mg/kg/hour for CrCL <30 mL/min or 0.25 mg/kg/hour if on dialysis.

Renal Dosing

Initial bolus dose remains unchanged. Monitor activated coagulation time (ACT).

[>30 ml/min]: No adjustment required

[10-29 ml/min]: Decrease infusion rate to 1 mg/kg/hour.

Hemodialysis

Dialysis-dependent patients (off dialysis): Decrease infusion rate to 0.25 mg/kg/hour. No reduction in the bolus dose is needed.

Source revision: Historical source; revision not established here | Retrieved: 2026-09-05. Retrieval date is not the revision date.

Source: https://globalrph.com/renal/bivalirudin/

Scope: Preserved historical source; no fresh clinical approval GlobalRPh v6.6.

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Retrieved: 2026-09-05

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Locally stored source content

Original GlobalRPh protocol

Clinical facts and comments transcribed into a structured reading format. This is not a byte-for-byte HTML archive. Original source: https://globalrph.com/renal/bivalirudin/

Usual Dosing (Adults)

Dosing and Administration

For patients who do not have HIT/HITTS: PCI/PTCA: 0.75 mg/kg intravenous (IV) bolus dose followed by a 1.75 mg/kg/h IV infusion for the duration of the procedure. Perform activated clotting time (ACT) test 5 minutes post-bolus dose. If needed, give an additional bolus of 0.3 mg/kg. After PCI/PTCA, IV infusion may be continued for up to 4 hours, after which a rate of 0.2 mg/kg/h can be used for up to 20 more hours, if needed.

Consider glycoprotein IIb/IIIa inhibitor (GPI) administration with procedural complications.

For patients who have HIT/HITTS: The recommended dose of Angiomax in patients with HIT/HITTS undergoing PCI is an IV bolus of 0.75 mg/kg. This should be followed by an infusion at a rate of 1.75 mg/kg/h for the duration of the procedure. After PCI/PTCA, IV infusion may be continued for up to 4 hours, after which a rate of 0.2 mg/kg/h can be used for up to 20 more hours, if needed.

For patients with Renal Impairment: No reduction in bolus dose required. Consider reduction of the rate of infusion to 1 mg/kg/hour for CrCL <30 mL/min or 0.25 mg/kg/hour if on dialysis.

GRPH-bivalirudin-01 · Source section: Usual Dosing (Adults)Renal section finder

Renal Dosing

Initial bolus dose remains unchanged. Monitor activated coagulation time (ACT).

[>30 ml/min]: No adjustment required

[10-29 ml/min]: Decrease infusion rate to 1 mg/kg/hour.

GRPH-bivalirudin-02 · Source section: Renal DosingRenal section finder

Hemodialysis

Dialysis-dependent patients (off dialysis): Decrease infusion rate to 0.25 mg/kg/hour. No reduction in the bolus dose is needed.

GRPH-bivalirudin-03 · Source section: HemodialysisRenal section finder

Provenance and preservation

Additional summaries stored on this page: 0 official-label, 0 RX List, 0 professional, 0 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source
https://globalrph.com/renal/bivalirudin/
Source retrieval
2026-09-05. This is not the source publication or label revision date.
Original source type
globalrph individual
Local text SHA-256
367219f7a3573a2c6abac3d4c75473e2c21940d7b8490545cadd091a9a5b5a1a
Import versus clinical validation
Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

The original individual GlobalRPh pages commonly cite NIH/NLM DailyMed and instruct readers to review the applicable package insert for updates. That historical reference is preserved as context; it is not counted as an independently retrieved current label.

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