GlobalRPh Renal Dosing Masterv6.6
Evidence addition

Atorvastatin (Lipitor)

Local official-label summaryBase record retrieved 2026-09-05See the evidence for this drug2 sources available - open source summaries, references and comparisons

Lipitor

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Official source

LIPITOR - adult lipid dosing and renal safety

Product / population
Adults; named product and route only. Selected dosing and renal summary, not the full prescribing information.
Renal measure
No renal-function dose bands specified for this summary.

Dosing / renal protocol and limits

Adults generally start 10-20 mg orally once daily; the labeled range is 10-80 mg daily. A 40-mg start may be used when an LDL reduction greater than 45% is needed. Renal impairment does not require dose reduction, but it increases the risk of myopathy/rhabdomyolysis, so monitor symptoms. Hemodialysis is not expected to substantially increase clearance; ESRD was not directly studied in that pharmacokinetic statement. Interaction-based dose limits still apply and are not overridden by the no-renal-adjustment statement.

Source revision: DailyMed updated 2024-04-15. | Retrieved: 2026-09-05. Retrieval date is not the revision date.

Source: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a60cc18b-0631-4cf0-b021-9f52224ece65

Scope: Locally included source-specific summary. Regimen differences are not automatically resolved. GlobalRPh v6.6.

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Source-first renal review

Evidence sources and renal implications

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Official product label

LIPITOR - adult lipid dosing and renal safety

Adults; named product and route only. Selected dosing and renal summary, not the full prescribing information.

Renal method: No renal-function dose bands specified for this summary.
Retrieved: 2026-09-05

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Handbook

Renal Drug Handbook, 5th edition - Atorvastatin

Historical adult renal/RRT summary. U.S. product identity anchored to the separate locally included DailyMed label. This is not a current U.S. product label.

Renal method: Book table headed GFR (mL/min); its preface states renal adjustments generally derive from Cockcroft-Gault CrCl. Do not silently relabel as indexed eGFR.
Retrieved: 2026-09-05

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All source summaries, original wording and provenance
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Renal-context checklist: population, kidney trend and dialysis

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See source-specific renal methods and the clinical interpretation guide for the supporting context.

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Renal dosing and precautions

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Handbook source

Renal Drug Handbook, 5th edition - Atorvastatin

Historical adult renal/RRT summary. U.S. product identity anchored to the separate locally included DailyMed label. This is not a current U.S. product label.

Method: Book table headed GFR (mL/min); its preface states renal adjustments generally derive from Cockcroft-Gault CrCl. Do not silently relabel as indexed eGFR.

Historical renal / replacement-therapy guidanceRead this complete source summary

No dialysis or renal heading shown? Read the complete source summary. Absence of a heading is not evidence that dose adjustment is unnecessary.

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Original content / product scopeLIPITOR - adult lipid dosing and renal safetyRenal Drug Handbook, 5th edition - Atorvastatin
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Exact product and population matter. This added page contains locally stored, source-specific clinical summaries. Historical handbook information, when present, is identified separately and may conflict with U.S. labeling. Confirm indication, population, kidney-function method, monitoring and the full prescribing information before applying a regimen.
Locally stored source content

Exact product and population

Product identity selected for the separately displayed source protocols below. Reference: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a60cc18b-0631-4cf0-b021-9f52224ece65

Product and population scope

Adult Atorvastatin (Lipitor). Use only the product, route, indication and renal-replacement setting explicitly stated in the source protocol selected below. Sources are alternatives to compare, not ingredients of a blended regimen.

SCOPE-atorvastatin · Source section: Editorial scope; each clinical recommendation is separately attributed belowRenal section finder
Separate U.S. product-label layer

FDA / DailyMed dosing and renal information

Official

LIPITOR - adult lipid dosing and renal safety

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NIH/NLM DailyMed - U.S. product labeling · Adults; named product and route only. Selected dosing and renal summary, not the full prescribing information.

Renal method: No renal-function dose bands specified for this summary.
Source date: DailyMed updated 2024-04-15.
Retrieved: 2026-09-05

Locally included source-specific summary. Regimen differences are not automatically resolved.

Dosing / renal protocol and limits

Adults generally start 10-20 mg orally once daily; the labeled range is 10-80 mg daily. A 40-mg start may be used when an LDL reduction greater than 45% is needed. Renal impairment does not require dose reduction, but it increases the risk of myopathy/rhabdomyolysis, so monitor symptoms. Hemodialysis is not expected to substantially increase clearance; ESRD was not directly studied in that pharmacokinetic statement. Interaction-based dose limits still apply and are not overridden by the no-renal-adjustment statement.

RDM30-080-atorvastatin-1 · Source locator: LIPITOR - adult lipid dosing and renal safety; renal/dosing sections and stated qualifiers

Source identity and provenance
Source
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a60cc18b-0631-4cf0-b021-9f52224ece65
Retrieved
2026-09-05
DailyMed Set ID
a60cc18b-0631-4cf0-b021-9f52224ece65
Renal-function method
No renal-function dose bands specified for this summary.
Source date/version
DailyMed updated 2024-04-15.
Hash meaning
Locally authored summary text; not original SPL, HTML or PDF bytes
Local summary SHA-256
c0d39c8beff5e954ca11cb9bc0da33e0a4de137ce3d99c92f48ae1dbe42899ee
Separate handbook layer

Renal Drug Handbook cross-check

Handbook

Renal Drug Handbook, 5th edition - Atorvastatin

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UK Renal Pharmacy Group / CRC Press · Historical adult renal/RRT summary. U.S. product identity anchored to the separate locally included DailyMed label. This is not a current U.S. product label.

Renal method: Book table headed GFR (mL/min); its preface states renal adjustments generally derive from Cockcroft-Gault CrCl. Do not silently relabel as indexed eGFR.
Source date: 5th edition; 2019 copyright; historical reference
Retrieved: 2026-09-05

Historical handbook cross-check; not a current U.S. protocol

Historical renal / replacement-therapy guidance

The 20-50, 10-20 and <10 mL/min bands retain the usual indication-specific dose. The stated range is 10-80 mg daily. HD and PD are described as not removing the drug; high-flux dialyzability is unknown. The book retains usual dosing for these modalities.

HB30-atorvastatin-1 · Source locator: Printed page 95: renal impairment, RRT and other information

Source-specific limits

Separate source recommendation, not proof of agreement or contemporary clinical validation. Dialysis predictions are retained with their original certainty.

Source identity and provenance
Retrieved
2026-09-05
Handbook page
5th edition, printed p. 95; uploaded PDF p. 114
Renal-function method
Book table headed GFR (mL/min); its preface states renal adjustments generally derive from Cockcroft-Gault CrCl. Do not silently relabel as indexed eGFR.
Source date/version
5th edition; 2019 copyright; historical reference
U.S. product identity basis
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a60cc18b-0631-4cf0-b021-9f52224ece65
Hash meaning
Local paraphrase; original book not redistributed
Local summary SHA-256
608142ebda3f0ba05c240bb974e629248fdec2dd91dce892f776b8cb07a9bfa5

Provenance and preservation

Additional summaries stored on this page: 1 official-label, 0 RX List, 0 professional, 1 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a60cc18b-0631-4cf0-b021-9f52224ece65
Source retrieval
2026-09-05. This is not the source publication or label revision date.
Original source type
multisource addition
Local text SHA-256
5a94607f48ad019752798ee9b964753b91021ed426f287603eebe879c13fa90e
Import versus clinical validation
Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

This page is an additional exact-product entry, not a recovered GlobalRPh monograph. Its primary scope text and separately attributed clinical summaries are locally included.

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