GlobalRPh Renal Dosing Masterv6.6
GlobalRPh source record

Amprenavir / source fosamprenavir discussion

GlobalRPh source pageBase record retrieved 2026-09-05See the evidence for this drug1 sources available - open source summaries, references and comparisons
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The original Amprenavir page supplies fosamprenavir dosing. These ingredients are not interchangeable, and the source statement about availability is historical, not a newly verified marketing claim.

Usual Dosing (Adults)

Production of amprenavir was discontinued by the manufacturer December 31, 2004; a prodrug version (fosamprenavir) is available.

LEXIVA (fosamprenavir calcium): Therapy-Naive Adults: LEXIVA 1,400 mg twice daily; LEXIVA 1,400 mg once daily plus ritonavir 200 mg once daily; LEXIVA 1,400 mg once daily plus ritonavir 100 mg once daily; LEXIVA 700 mg twice daily plus ritonavir 100 mg twice daily.

Protease Inhibitor-Experienced Adults: LEXIVA 700 mg twice daily plus ritonavir 100 mg twice daily.

Pediatric Patients (2 to 18 years of age): Dosage should be calculated based on body weight (kg) and should not exceed adult dose. Hepatic Impairment: Recommended adjustments for patients with mild, moderate, or severe hepatic impairment.

Dosing Considerations: LEXIVA Tablets may be taken with or without food. LEXIVA Suspension: Adults should take without food; pediatric patients should take with food.

Renal Dosing

Renal Impairment: The impact of renal impairment on amprenavir elimination in adult patients has not been studied. The renal elimination of unchanged amprenavir represents approximately 1% of the administered dose; therefore, renal impairment is not expected to significantly impact the elimination of amprenavir.

Hemodialysis

Insufficient data

Source revision: Historical source; revision not established here | Retrieved: 2026-09-05. Retrieval date is not the revision date.

Source: https://globalrph.com/renal/amprenavir/

Scope: Preserved historical source; no fresh clinical approval GlobalRPh v6.6.

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Retrieved: 2026-09-05

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Important source distinctions

The original Amprenavir page supplies fosamprenavir dosing. These ingredients are not interchangeable, and the source statement about availability is historical, not a newly verified marketing claim.

Locally stored source content

Original GlobalRPh protocol

Clinical facts and comments transcribed into a structured reading format. This is not a byte-for-byte HTML archive. Original source: https://globalrph.com/renal/amprenavir/

Usual Dosing (Adults)

Production of amprenavir was discontinued by the manufacturer December 31, 2004; a prodrug version (fosamprenavir) is available.

LEXIVA (fosamprenavir calcium): Therapy-Naive Adults: LEXIVA 1,400 mg twice daily; LEXIVA 1,400 mg once daily plus ritonavir 200 mg once daily; LEXIVA 1,400 mg once daily plus ritonavir 100 mg once daily; LEXIVA 700 mg twice daily plus ritonavir 100 mg twice daily.

Protease Inhibitor-Experienced Adults: LEXIVA 700 mg twice daily plus ritonavir 100 mg twice daily.

Pediatric Patients (2 to 18 years of age): Dosage should be calculated based on body weight (kg) and should not exceed adult dose. Hepatic Impairment: Recommended adjustments for patients with mild, moderate, or severe hepatic impairment.

Dosing Considerations: LEXIVA Tablets may be taken with or without food. LEXIVA Suspension: Adults should take without food; pediatric patients should take with food.

GRPH-amprenavir-01 · Source section: Usual Dosing (Adults)Renal section finder

Renal Dosing

Renal Impairment: The impact of renal impairment on amprenavir elimination in adult patients has not been studied. The renal elimination of unchanged amprenavir represents approximately 1% of the administered dose; therefore, renal impairment is not expected to significantly impact the elimination of amprenavir.

GRPH-amprenavir-02 · Source section: Renal DosingRenal section finder

Provenance and preservation

Additional summaries stored on this page: 0 official-label, 0 RX List, 0 professional, 0 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source
https://globalrph.com/renal/amprenavir/
Source retrieval
2026-09-05. This is not the source publication or label revision date.
Original source type
globalrph individual
Local text SHA-256
894c197d397d49f57dc71b66f5cd6ae7f81d83a533f9b7fb14519ef3c075f6f7
Import versus clinical validation
Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

The original individual GlobalRPh pages commonly cite NIH/NLM DailyMed and instruct readers to review the applicable package insert for updates. That historical reference is preserved as context; it is not counted as an independently retrieved current label.

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