GlobalRPh Renal Dosing Masterv6.6
Evidence addition

Amlodipine - single agent

Local official-label summaryBase record retrieved 2026-09-05See the evidence for this drug2 sources available - open source summaries, references and comparisons
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Official source

Amlodipine single-agent tablets - starting dose and renal statement

Product / population
Adults; named product and route only. Selected dosing and renal summary, not the full prescribing information.
Renal measure
No renal-function dose bands specified for this summary.

Dosing / renal protocol and limits

Adult hypertension: begin 5 mg orally once daily and titrate to a maximum of 10 mg daily. A 2.5-mg starting dose may be appropriate for small, frail or elderly patients, or hepatic insufficiency. Renal failure alone does not require lowering the usual starting dose. Titrate to blood pressure and tolerability; generally allow 7-14 days between changes. This selected repackaged label has an older revision; current availability of its NDC is not claimed.

Source revision: Selected repackaged label updated 2022-01-21; prescribing text revised January 2017. | Retrieved: 2026-09-05. Retrieval date is not the revision date.

Source: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=56d031db-67ed-217d-e054-00144ff88e88

Scope: Locally included source-specific summary. Regimen differences are not automatically resolved. GlobalRPh v6.6.

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Source-first renal review

Evidence sources and renal implications

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Official product label

Amlodipine single-agent tablets - starting dose and renal statement

Adults; named product and route only. Selected dosing and renal summary, not the full prescribing information.

Renal method: No renal-function dose bands specified for this summary.
Retrieved: 2026-09-05

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Handbook

Renal Drug Handbook, 5th edition - Amlodipine

Historical adult renal/RRT summary. U.S. product identity anchored to the separate locally included DailyMed label. This is not a current U.S. product label.

Renal method: Book table headed GFR (mL/min); its preface states renal adjustments generally derive from Cockcroft-Gault CrCl. Do not silently relabel as indexed eGFR.
Retrieved: 2026-09-05

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Renal-context checklist: population, kidney trend and dialysis

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Renal dosing and precautions

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Handbook source

Renal Drug Handbook, 5th edition - Amlodipine

Historical adult renal/RRT summary. U.S. product identity anchored to the separate locally included DailyMed label. This is not a current U.S. product label.

Method: Book table headed GFR (mL/min); its preface states renal adjustments generally derive from Cockcroft-Gault CrCl. Do not silently relabel as indexed eGFR.

Historical renal / replacement-therapy guidanceRead this complete source summary

No dialysis or renal heading shown? Read the complete source summary. Absence of a heading is not evidence that dose adjustment is unnecessary.

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Original content / product scopeAmlodipine single-agent tablets - starting dose and renal statementRenal Drug Handbook, 5th edition - Amlodipine
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Exact product and population matter. This added page contains locally stored, source-specific clinical summaries. Historical handbook information, when present, is identified separately and may conflict with U.S. labeling. Confirm indication, population, kidney-function method, monitoring and the full prescribing information before applying a regimen.
Locally stored source content

Exact product and population

Product identity selected for the separately displayed source protocols below. Reference: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=56d031db-67ed-217d-e054-00144ff88e88

Product and population scope

Adult Amlodipine - single agent. Use only the product, route, indication and renal-replacement setting explicitly stated in the source protocol selected below. Sources are alternatives to compare, not ingredients of a blended regimen.

SCOPE-amlodipine · Source section: Editorial scope; each clinical recommendation is separately attributed belowRenal section finder
Separate U.S. product-label layer

FDA / DailyMed dosing and renal information

Official

Amlodipine single-agent tablets - starting dose and renal statement

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NIH/NLM DailyMed - U.S. product labeling · Adults; named product and route only. Selected dosing and renal summary, not the full prescribing information.

Renal method: No renal-function dose bands specified for this summary.
Source date: Selected repackaged label updated 2022-01-21; prescribing text revised January 2017.
Retrieved: 2026-09-05

Locally included source-specific summary. Regimen differences are not automatically resolved.

Dosing / renal protocol and limits

Adult hypertension: begin 5 mg orally once daily and titrate to a maximum of 10 mg daily. A 2.5-mg starting dose may be appropriate for small, frail or elderly patients, or hepatic insufficiency. Renal failure alone does not require lowering the usual starting dose. Titrate to blood pressure and tolerability; generally allow 7-14 days between changes. This selected repackaged label has an older revision; current availability of its NDC is not claimed.

RDM30-079-amlodipine-1 · Source locator: Amlodipine single-agent tablets - starting dose and renal statement; renal/dosing sections and stated qualifiers

Source identity and provenance
Source
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=56d031db-67ed-217d-e054-00144ff88e88
Retrieved
2026-09-05
DailyMed Set ID
56d031db-67ed-217d-e054-00144ff88e88
Renal-function method
No renal-function dose bands specified for this summary.
Source date/version
Selected repackaged label updated 2022-01-21; prescribing text revised January 2017.
Hash meaning
Locally authored summary text; not original SPL, HTML or PDF bytes
Local summary SHA-256
ff91a8a9914df7836e131baa14c3b57fd8c0d4c238681d5e906cf460b95b35b6
Separate handbook layer

Renal Drug Handbook cross-check

Handbook

Renal Drug Handbook, 5th edition - Amlodipine

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UK Renal Pharmacy Group / CRC Press · Historical adult renal/RRT summary. U.S. product identity anchored to the separate locally included DailyMed label. This is not a current U.S. product label.

Renal method: Book table headed GFR (mL/min); its preface states renal adjustments generally derive from Cockcroft-Gault CrCl. Do not silently relabel as indexed eGFR.
Source date: 5th edition; 2019 copyright; historical reference
Retrieved: 2026-09-05

Historical handbook cross-check; not a current U.S. protocol

Historical renal / replacement-therapy guidance

The 20-50, 10-20 and <10 mL/min bands retain the usual indication-specific dose. The book lists 5-10 mg orally daily. HD and PD are described as not removing the drug; high-flux removal is considered unlikely. These are historical renal statements, not instructions to bypass blood-pressure titration.

HB30-amlodipine-1 · Source locator: Printed page 60: renal impairment, RRT and other information

Source-specific limits

Separate source recommendation, not proof of agreement or contemporary clinical validation. Dialysis predictions are retained with their original certainty.

Source identity and provenance
Retrieved
2026-09-05
Handbook page
5th edition, printed p. 60; uploaded PDF p. 79
Renal-function method
Book table headed GFR (mL/min); its preface states renal adjustments generally derive from Cockcroft-Gault CrCl. Do not silently relabel as indexed eGFR.
Source date/version
5th edition; 2019 copyright; historical reference
U.S. product identity basis
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=56d031db-67ed-217d-e054-00144ff88e88
Hash meaning
Local paraphrase; original book not redistributed
Local summary SHA-256
a656d4b348b465cd346c359a5e4bb1fdd7e92d8801e011252d5dbdea95b5fae4

Provenance and preservation

Additional summaries stored on this page: 1 official-label, 0 RX List, 0 professional, 1 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=56d031db-67ed-217d-e054-00144ff88e88
Source retrieval
2026-09-05. This is not the source publication or label revision date.
Original source type
multisource addition
Local text SHA-256
7d64ef67d49ea577aa909e21db2bf2308ab2d1f0ea996bd67f45e406b44318fc
Import versus clinical validation
Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

This page is an additional exact-product entry, not a recovered GlobalRPh monograph. Its primary scope text and separately attributed clinical summaries are locally included.

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