GlobalRPh Renal Dosing Masterv6.6
GlobalRPh source record

Adefovir

Local RX List renal extractBase record retrieved 2026-09-05See the evidence for this drug2 sources available - open source summaries, references and comparisons
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Rxlist source

GlobalRPh RX List - HEPSERA

Product / population
Adult oral adefovir for chronic hepatitis B; not a preferred-therapy recommendation
Renal measure
Cockcroft-Gault CrCl using lean or ideal body weight; mL/min

RX mirror: this is not independent corroboration of its underlying label. Check dated-label and formulation limitations.

Renal dosing, restrictions and evidence limits

Adult baseline renal impairment: 10 mg orally every 24 hours at CrCl >=50 mL/min, every 48 hours at 30-49, and every 72 hours at 10-29. Hemodialysis: 10 mg every seven days after dialysis. The table specifies Cockcroft-Gault with lean or ideal body weight.

No regimen is available below 10 mL/min without hemodialysis or for adolescents with renal insufficiency. These interval adjustments were not clinically validated for safety/effectiveness and were derived from pre-existing renal impairment; they may not apply when renal injury develops during treatment. Follow renal function and antiviral response closely. Peritoneal-dialysis removal was not evaluated.

Source revision: December 2018 | Retrieved: 2026-09-07. Retrieval date is not the revision date.

Source: https://globalrph.com/rx-list/hepsera-drug/

Scope: Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph. GlobalRPh v6.6.

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Evidence sources and renal implications

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Preserved GlobalRPh source

Preserved original GlobalRPh source

Preserved historical content; not revalidated as current prescribing guidance.

Renal method: Read the measure and population stated in the original source sections.
Retrieved: 2026-09-05

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GlobalRPh RX List

GlobalRPh RX List - HEPSERA

Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.

Adult oral adefovir for chronic hepatitis B; not a preferred-therapy recommendation

Renal method: Cockcroft-Gault CrCl using lean or ideal body weight; mL/min
Retrieved: 2026-09-07

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Source presence is not independent validation. A label mirror is not a second independent source; review the original reference and exact formulation.

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Renal dosing and precautions

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New source summary - independent clinical review pending. Summaries of the identified label sections are included locally. Source import and numeric transcription checks are not independent two-reference validation. Do not treat this card as an approved institutional dosing protocol.

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Original content / product scopeGlobalRPh RX List - HEPSERA
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Historical source content is not a current prescription. Original GlobalRPh recommendations are preserved, not automatically certified as current. Product-label and professional additions below are separately attributed. Confirm indication, population, kidney-function method, monitoring and the full prescribing information before applying a regimen.
Locally stored source content

Original GlobalRPh protocol

Clinical facts and comments transcribed into a structured reading format. This is not a byte-for-byte HTML archive. Original source: https://globalrph.com/renal/adefovir/

Usual Dosing (Adults)

Chronic Hepatitis B: 10 mg orally once daily

GRPH-adefovir-01 · Source section: Usual Dosing (Adults)Renal section finder

Renal Dosing

Oral:

[>50 ml/min]: No Change

[20-49]: 10 mg every 48 hours

[10-19]: 10 mg every 72 hours

[<10 ml/min]: See under hemodialysis

GRPH-adefovir-02 · Source section: Renal DosingRenal section finder

Hemodialysis

10 mg every 7 days (following dialysis)

GRPH-adefovir-03 · Source section: HemodialysisRenal section finder
Locally imported selected renal sections

GlobalRPh RX List renal information

Rxlist

GlobalRPh RX List - HEPSERA

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GlobalRPh-hosted RX List · Adult oral adefovir for chronic hepatitis B; not a preferred-therapy recommendation

Renal method: Cockcroft-Gault CrCl using lean or ideal body weight; mL/min
Source date: December 2018
Retrieved: 2026-09-07

Label mirror, not independent corroboration. This is selected locally stored RX List content. Full monograph import and current official-label review are not implied.
Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.

Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph.

Renal dosing, restrictions and evidence limits

Adult baseline renal impairment: 10 mg orally every 24 hours at CrCl >=50 mL/min, every 48 hours at 30-49, and every 72 hours at 10-29. Hemodialysis: 10 mg every seven days after dialysis. The table specifies Cockcroft-Gault with lean or ideal body weight.

No regimen is available below 10 mL/min without hemodialysis or for adolescents with renal insufficiency. These interval adjustments were not clinically validated for safety/effectiveness and were derived from pre-existing renal impairment; they may not apply when renal injury develops during treatment. Follow renal function and antiviral response closely. Peritoneal-dialysis removal was not evaluated.

RDM38-rxlist-adefovir-9bd7a480fa-C1 · Source locator: Dosage: table 1; nephrotoxicity; renal pharmacokinetics

Source identity and provenance
Source family
product_label_mirror
Source
https://globalrph.com/rx-list/hepsera-drug/
Retrieved
2026-09-07
Renal-function method
Cockcroft-Gault CrCl using lean or ideal body weight; mL/min
Source date/version
December 2018
Hash meaning
SHA-256 of local authored summary only; not original HTML, PDF or SPL bytes.
Local summary SHA-256
08627fe95b65f4042eb379a2b6457d9e97fe583cbf8016aab38cf503ecd482eb

Provenance and preservation

Additional summaries stored on this page: 0 official-label, 1 RX List, 0 professional, 0 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source
https://globalrph.com/renal/adefovir/
Source retrieval
2026-09-05. This is not the source publication or label revision date.
Original source type
globalrph individual
Local text SHA-256
fd2ebe030416d1a8201005345ccce1dfa11f876e721b98362f8f78994a551e2f
Import versus clinical validation
Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

The original individual GlobalRPh pages commonly cite NIH/NLM DailyMed and instruct readers to review the applicable package insert for updates. That historical reference is preserved as context; it is not counted as an independently retrieved current label.

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