GlobalRPh RX List - LITHOSTAT
- Product / population
- LITHOSTAT oral adjunct for chronic urea-splitting urinary infection. Source eligibility exclusions, including suitability for definitive treatment, remain essential.
- Renal measure
- Serum creatinine, mg/dL, and a separate CrCl, mL/min, contraindication
RX mirror: this is not independent corroboration of its underlying label. Check dated-label and formulation limitations.
Selected sections only. A hosted mirror is not independent confirmation of the underlying label.
Renal dosing, restrictions and evidence limits
At serum creatinine above 1.8 mg/dL, the source limits the daily total to 1 g, administered every 12 hours. It does not define the optimal further reduction or interval as renal function worsens. The contraindication applies when serum creatinine exceeds 2.5 mg/dL and/or CrCl is below 20 mL/min.
The label advises CBC and reticulocyte assessment after two weeks and at three-month intervals; a reticulocyte count above 6% warrants consideration of dose reduction. This is not a complete antimicrobial or dialysis protocol. Do not convert the source's untested dialyzability expectation into a supplemental-dose rule.