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Clinical context remains essential
Independent clinical review is pending. Confirm indication, exact formulation/route, population, renal measure and units, kidney-function stability, dialysis prescription, interacting drugs, monitoring and source revision. An RX mirror and its original label are not independent corroboration. Missing disagreement notes do not certify agreement.
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Renal Drug Handbook, fifth edition - Donepezil tablets (mild to moderate Alzheimer disease)
Product / population
Historical renal/RRT cross-check for the named ingredient; not a current U.S. prescribing instruction.
Renal method
Book table headings say GFR (mL/min); the preface states adjustment information is based on Cockcroft-Gault CrCl, not indexed eGFR. Do not substitute methods.
Source revision
Fifth edition, 2019
Retrieved
2026-09-05
Local review status
Historical source, separately displayed. Renal tables were read with page-image inspection.
Handbook
Renal Drug Handbook, fifth edition - Donepezil tablets (mild to moderate Alzheimer disease)
UK Renal Pharmacy Group / CRC Press · Historical renal/RRT cross-check for the named ingredient; not a current U.S. prescribing instruction.
Renal method: Book table headings say GFR (mL/min); the preface states adjustment information is based on Cockcroft-Gault CrCl, not indexed eGFR. Do not substitute methods. Source date: Fifth edition, 2019 Retrieved: 2026-09-05
Historical source, separately displayed. Renal tables were read with page-image inspection.
Historical renal and dialysis observations
The historical 20-50, 10-20 and below-10 mL/min bands all retain usual dosing. Peritoneal, conventional HD and continuous removal are described as unlikely; high-flux/HDF removal is unknown. No reduction is proposed for those modalities.
RDM31-donepezil-tablets-book · Source locator: Dose in renal impairment; renal replacement therapies; Other information
Source-specific limits
The dialysis statements are the book's historical assessment; the label study is not a dialysis efficacy study.
Source identity and provenance
Retrieved
2026-09-05
Handbook page
Printed page(s) 335; PDF page(s) 354
Renal-function method
Book table headings say GFR (mL/min); the preface states adjustment information is based on Cockcroft-Gault CrCl, not indexed eGFR. Do not substitute methods.
This reference does not select a regimen. Complete the indication, measured/estimated renal function and trend, dialysis setting, source rationale, monitoring and reassessment plan in your institution's approved documentation system. Confirm the complete current source before adopting its regimen.
GlobalRPh v6.6 | RDM66-DIRECT-PHP-20260911 | Local library date 2026-09-11. Selected-card identity does not imply clinical verification.