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Independent clinical review is pending. Confirm indication, exact formulation/route, population, renal measure and units, kidney-function stability, dialysis prescription, interacting drugs, monitoring and source revision. An RX mirror and its original label are not independent corroboration. Missing disagreement notes do not certify agreement.
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Otrexup - labeled renal guidance
Product / population
Methotrexate (Otrexup), subcutaneous injection
Renal method
Renal impairment categories as defined by the cited product label
DailyMed / product prescribing information · Methotrexate (Otrexup), subcutaneous injection
Renal method: Renal impairment categories as defined by the cited product label Source date: DailyMed SPL version 15, posted Feb 03, 2025 Retrieved: 2026-11-07
Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.
Renal guidance: 5.6 Patients with Impaired Renal Function, Ascites, or Pleural Effusions / 8.6 Renal Impairment
Renal dysfunction reduces methotrexate elimination. Monitor closely for toxicity and reduce the dose or discontinue when indicated. Verify the once-weekly subcutaneous autoinjector, prescribed strength and indication.
RDM74-otrexup-official-1 · Source locator: Renal guidance: 5.6 Patients with Impaired Renal Function, Ascites, or Pleural Effusions / 8.6 Renal Impairment
This reference does not select a regimen. Complete the indication, measured/estimated renal function and trend, dialysis setting, source rationale, monitoring and reassessment plan in your institution's approved documentation system. Confirm the complete current source before adopting its regimen.
GlobalRPh Renal Dosing Master v7.4. Review the retrieval and revision dates attached to each source. Selecting a reference does not imply clinical verification.
