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1 local source card selected. Local card fingerprints checked where supplied. This is not an original-document hash, source-currency guarantee or clinical approval. Record-level cautions below are the current library's cautions, not a frozen prior version.
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Clinical context remains essential
Independent clinical review is pending. Confirm indication, exact formulation/route, population, renal measure and units, kidney-function stability, dialysis prescription, interacting drugs, monitoring and source revision. An RX mirror and its original label are not independent corroboration. Missing disagreement notes do not certify agreement.
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Ivosidenib tablets (Tibsovo) - selected U.S. label sections
Product / population
TIBSOVO oral tablets; retain the underlying indication-specific treatment plan.
Renal method
MDRD eGFR in mL/min/1.73 m2
Source revision
Revision not captured; retrieval date is not the revision date.
Retrieved
2026-09-05
Local review status
Local label summary; independent clinical review pending. Not a two-source validated protocol.
Official
Ivosidenib tablets (Tibsovo) - selected U.S. label sections
U.S. product labeling / DailyMed · TIBSOVO oral tablets; retain the underlying indication-specific treatment plan.
Renal method: MDRD eGFR in mL/min/1.73 m2 Source date: Revision not captured; retrieval date is not the revision date. Retrieved: 2026-09-05
Local label summary; independent clinical review pending. Not a two-source validated protocol.
Renal impairment comments
No modification of the starting dose is recommended for mild or moderate impairment, with MDRD eGFR at least 30. Pharmacokinetics and safety below 30 or with hemodialysis are unknown. Consider risks and potential benefits before use in severe impairment or dialysis.
RDM32-ivosidenib-tibsovo-1 · Source locator: 8.6
Source-specific limits
Selected renal sections only, not a complete monograph. Exact product, indication, patient population, renal method and all other contraindications/interactions remain controlling.
Second independent renal reference and clinician adjudication remain pending; no all-indication, dialysis or pediatric dose may be inferred from an omitted field.
This reference does not select a regimen. Complete the indication, measured/estimated renal function and trend, dialysis setting, source rationale, monitoring and reassessment plan in your institution's approved documentation system. Confirm the complete current source before adopting its regimen.
GlobalRPh v6.6 | RDM66-DIRECT-PHP-20260911 | Local library date 2026-09-11. Selected-card identity does not imply clinical verification.