GlobalRPh Renal Dosing Masterv6.6
Source review / handoff

Ertapenem (Invanz)

One or two intact local summaries. No averaged regimen, patient-specific dose or automatic source preference.

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1 local source card selected. Local card fingerprints checked where supplied. This is not an original-document hash, source-currency guarantee or clinical approval. Record-level cautions below are the current library's cautions, not a frozen prior version.

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Clinical context remains essential

Independent clinical review is pending. Confirm indication, exact formulation/route, population, renal measure and units, kidney-function stability, dialysis prescription, interacting drugs, monitoring and source revision. An RX mirror and its original label are not independent corroboration. Missing disagreement notes do not certify agreement.

The source uses indexed renal thresholds but prints an unindexed Cockcroft-Gault formula; preserve the distinction rather than silently treating the units as equivalent.

Check source scope before reading a dose

Sunnybrook - ertapenem renal and replacement-therapy schedule

Product / population
Adult institutional ertapenem guidance.
Renal method
CrCl in mL/min; HD, PD, CRRT and SLED distinguished.
Source revision
Revision date not stated in the reviewed page.
Retrieved
2026-09-05
Local review status
Locally included source-specific summary. Regimen differences are not automatically resolved.

Documented differences and cautions on this drug

All record notes are retained here, including notes about sources not selected in this review.

Daily label regimen versus case-by-case post-HD institutional dosing

The label mirror uses a daily renal regimen with a timing-dependent post-HD supplement. UCSF also offers a selected post-HD-only strategy, with toxicity, age and low-weight qualifications. The source renal units and exactly-30 boundary do not align automatically.

What to reconcile: Use one complete protocol with the dialysis prescription and ID/pharmacy review. Do not add the label supplement to an institutional post-HD dose or silently equate indexed and unindexed clearance.

Source-specific interpretation; independent clinician adjudication pending.

Open this note and its source references

Exactly six hours before HD: overlapping source wording

The label mirror says a supplement is needed within six hours but not needed when the dose is at least six hours before dialysis. The boundary is overlapping as printed.

What to reconcile: Clarify the timing endpoint with the controlling product label and dialysis pharmacist. Do not round an administration time to decide which instruction applies.

Source-specific interpretation; independent clinician adjudication pending.

Open this note and its source references
Professional

Sunnybrook - ertapenem renal and replacement-therapy schedule

Open original reference

Sunnybrook Health Sciences Centre, Canada · Adult institutional ertapenem guidance.

Renal method: CrCl in mL/min; HD, PD, CRRT and SLED distinguished.
Source date: Revision date not stated in the reviewed page.
Retrieved: 2026-09-05

Source recheck unresolved. Prior follow-up retrieval/version warning retained; not resolved by v6.0. Read source-review status

Locally included source-specific summary. Regimen differences are not automatically resolved.

Dosing / renal protocol and limits

Usual 1 g daily is retained at CrCl 30-49 mL/min and during CRRT. At 10-29, below 10, PD or HD: 500 mg daily; on HD days give toward session end. SLED days use 1 g IV daily, with the ESRD schedule on non-dialysis days. This Canadian institutional protocol is not U.S. labeling.

RDM30-064-ertapenem-1 · Source locator: Sunnybrook - ertapenem renal and replacement-therapy schedule; renal/dosing sections and stated qualifiers

Source identity and provenance
Source
https://sunnybrook.ca/antimicrobial-stewardship/renal-dosing-and-insufficiency-drug-dosing-considerations/
Retrieved
2026-09-05
Renal-function method
CrCl in mL/min; HD, PD, CRRT and SLED distinguished.
Source date/version
Revision date not stated in the reviewed page.
Hash meaning
Locally authored summary text; not original SPL, HTML or PDF bytes
Local summary SHA-256
2a8503af70040e5866b9f3cf9e5b89f3b3278e18512bd771818d0b00cb3aa47d

Document the clinical decision separately

This reference does not select a regimen. Complete the indication, measured/estimated renal function and trend, dialysis setting, source rationale, monitoring and reassessment plan in your institution's approved documentation system. Confirm the complete current source before adopting its regimen.

GlobalRPh v6.6 | RDM66-DIRECT-PHP-20260911 | Local library date 2026-09-11. Selected-card identity does not imply clinical verification.

Pinned reference: https://globalrph.com/blogCalcs/renal-dosing-master/compare.php?id=ertapenem&s1=RDM30-064-ertapenem&h1=f48a2b8300d3327d48ffb1eb98737a79dee16011b2d9930f7d4f62fb045ff893