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Clinical context remains essential
Independent clinical review is pending. Confirm indication, exact formulation/route, population, renal measure and units, kidney-function stability, dialysis prescription, interacting drugs, monitoring and source revision. An RX mirror and its original label are not independent corroboration. Missing disagreement notes do not certify agreement.
The source uses indexed renal thresholds but prints an unindexed Cockcroft-Gault formula; preserve the distinction rather than silently treating the units as equivalent.
Check source scope before reading a dose
Sunnybrook - ertapenem renal and replacement-therapy schedule
Product / population
Adult institutional ertapenem guidance.
Renal method
CrCl in mL/min; HD, PD, CRRT and SLED distinguished.
Source revision
Revision date not stated in the reviewed page.
Retrieved
2026-09-05
Local review status
Locally included source-specific summary. Regimen differences are not automatically resolved.
Documented differences and cautions on this drug
All record notes are retained here, including notes about sources not selected in this review.
Daily label regimen versus case-by-case post-HD institutional dosing
The label mirror uses a daily renal regimen with a timing-dependent post-HD supplement. UCSF also offers a selected post-HD-only strategy, with toxicity, age and low-weight qualifications. The source renal units and exactly-30 boundary do not align automatically.
What to reconcile: Use one complete protocol with the dialysis prescription and ID/pharmacy review. Do not add the label supplement to an institutional post-HD dose or silently equate indexed and unindexed clearance.
Exactly six hours before HD: overlapping source wording
The label mirror says a supplement is needed within six hours but not needed when the dose is at least six hours before dialysis. The boundary is overlapping as printed.
What to reconcile: Clarify the timing endpoint with the controlling product label and dialysis pharmacist. Do not round an administration time to decide which instruction applies.
Sunnybrook Health Sciences Centre, Canada · Adult institutional ertapenem guidance.
Renal method: CrCl in mL/min; HD, PD, CRRT and SLED distinguished. Source date: Revision date not stated in the reviewed page. Retrieved: 2026-09-05
Source recheck unresolved. Prior follow-up retrieval/version warning retained; not resolved by v6.0. Read source-review status
Locally included source-specific summary. Regimen differences are not automatically resolved.
Dosing / renal protocol and limits
Usual 1 g daily is retained at CrCl 30-49 mL/min and during CRRT. At 10-29, below 10, PD or HD: 500 mg daily; on HD days give toward session end. SLED days use 1 g IV daily, with the ESRD schedule on non-dialysis days. This Canadian institutional protocol is not U.S. labeling.
RDM30-064-ertapenem-1 · Source locator: Sunnybrook - ertapenem renal and replacement-therapy schedule; renal/dosing sections and stated qualifiers
This reference does not select a regimen. Complete the indication, measured/estimated renal function and trend, dialysis setting, source rationale, monitoring and reassessment plan in your institution's approved documentation system. Confirm the complete current source before adopting its regimen.
GlobalRPh v6.6 | RDM66-DIRECT-PHP-20260911 | Local library date 2026-09-11. Selected-card identity does not imply clinical verification.