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Clinical context remains essential
Independent clinical review is pending. Confirm indication, exact formulation/route, population, renal measure and units, kidney-function stability, dialysis prescription, interacting drugs, monitoring and source revision. An RX mirror and its original label are not independent corroboration. Missing disagreement notes do not certify agreement.
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eviQ Ewing sarcoma IE: ifosfamide kidney guidance
Product / population
eviQ protocol 3465, Ewing sarcoma IE part of VDC/IE; ifosfamide column only. Not an isolated-agent starting dose.
Renal method
eGFR mL/min/1.73 m2.
Source revision
Source revision date not established in selected retrieval.
Retrieved
2026-09-07
Local review status
Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph.
Documented differences and cautions on this drug
All record notes are retained here, including notes about sources not selected in this review.
Ifosfamide kidney guidance differs between Ewing IE and lymphoma RICE
The two eviQ protocols treat severe kidney impairment differently: the Ewing regimen directs an alternative where the fractionated lymphoma regimen permits a reduction or alternative. The label itself supplies qualitative renal precautions, not these numeric bands.
What to reconcile: Match the malignancy, full chemotherapy protocol, intent, renal measurement and KRT. Different protocols from the same organization are not independent validation or interchangeable prescriptions.
Baseline kidney modification does not replace tubular-toxicity surveillance
Protocol-based baseline modifications coexist with the label warning about glomerular and tubular injury, including delayed effects. A baseline reduction is not proof that treatment-emergent injury is controlled.
What to reconcile: Review renal trends and tubular/electrolyte findings throughout and after treatment; consider the complete toxicity management instructions rather than continuing from a baseline table alone.
eviQ / Cancer Institute NSW · eviQ protocol 3465, Ewing sarcoma IE part of VDC/IE; ifosfamide column only. Not an isolated-agent starting dose.
Renal method: eGFR mL/min/1.73 m2. Source date: Source revision date not established in selected retrieval. Retrieved: 2026-09-07
Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.
Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph.
Renal dosing, restrictions and evidence limits
For this protocol, ifosfamide is full dose at eGFR at least 60 and at 45-59, with increased adverse-event risk in the latter band. At 30-44, reduce by 20% or select an alternative protocol. At 15-29, use an alternative protocol; the page notes possible use in other circumstances but not this regimen. Below 15 without KRT, avoid and use an alternative. KRT requires multidisciplinary oncology/nephrology/pharmacology input. Reductions apply to each starting dose, not automatically to cycle duration.
This reference does not select a regimen. Complete the indication, measured/estimated renal function and trend, dialysis setting, source rationale, monitoring and reassessment plan in your institution's approved documentation system. Confirm the complete current source before adopting its regimen.
GlobalRPh v6.6 | RDM66-DIRECT-PHP-20260911 | Local library date 2026-09-11. Selected-card identity does not imply clinical verification.