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1 local source card selected. Local card fingerprints checked where supplied. This is not an original-document hash, source-currency guarantee or clinical approval. Record-level cautions below are the current library's cautions, not a frozen prior version.
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Clinical context remains essential
Independent clinical review is pending. Confirm indication, exact formulation/route, population, renal measure and units, kidney-function stability, dialysis prescription, interacting drugs, monitoring and source revision. An RX mirror and its original label are not independent corroboration. Missing disagreement notes do not certify agreement.
High-priority source disagreement: the old handbook supplies small doses in severe renal disease, while the later toxicity recommendation advises avoidance. No patient-specific safe dose is calculated.
Check source scope before reading a dose
Baclofen oral immediate-release tablets - selected U.S. labeling
Product / population
Adults with spasticity; oral immediate-release baclofen only. Intrathecal doses and pump management are excluded. Severe kidney impairment is a high-risk toxicity setting.
Renal method
Qualitative labeling only. The separate professional recommendation uses indexed eGFR.
Source revision
Label revision date not separately recorded; retrieval date is not the revision date.
Retrieved
2026-09-05
Local review status
Selected dosing/renal sections read; concise local summary, not full prescribing information.
Documented differences and cautions on this drug
All record notes are retained here, including notes about sources not selected in this review.
Older-adult avoidance guidance is more conservative than a generic reduction instruction
AGS 2023 recommends avoidance in older adults below its eGFR threshold, whereas the product-label summary advises caution and possible reduction.
What to reconcile: Review the age-specific source before using a reduced-dose schedule. The geriatric warning is not an intrathecal dosing rule.
U.S. product labeling / DailyMed · Adults with spasticity; oral immediate-release baclofen only. Intrathecal doses and pump management are excluded. Severe kidney impairment is a high-risk toxicity setting.
Renal method: Qualitative labeling only. The separate professional recommendation uses indexed eGFR. Source date: Label revision date not separately recorded; retrieval date is not the revision date. Retrieved: 2026-09-05
Selected dosing/renal sections read; concise local summary, not full prescribing information.
Labeled basic dosing
The general label titration begins 5 mg orally three times daily for 3 days, then 10, 15 and 20 mg three times daily at successive 3-day steps. Maximum 80 mg/day. This is NOT a renal-adjusted schedule.
RDM31-baclofen-oral-label-dose · Source locator: Dosage and Administration
Renal information and dialysis
The label urges caution and possible dose reduction because renal excretion is substantial. It does not provide numeric CrCl-based doses or a safe dialysis dose.
RDM31-baclofen-oral-label-renal · Source locator: Warnings: Impaired Renal Function
Selected warnings and limits
Toxicity may include profound sedation, coma, respiratory depression and seizures. Avoid abrupt withdrawal except when serious adverse reactions require a different immediate plan.
RDM31-baclofen-oral-label-limits · Source locator: Warnings; Overdosage: signs and symptoms
This reference does not select a regimen. Complete the indication, measured/estimated renal function and trend, dialysis setting, source rationale, monitoring and reassessment plan in your institution's approved documentation system. Confirm the complete current source before adopting its regimen.
GlobalRPh v6.6 | RDM66-DIRECT-PHP-20260911 | Local library date 2026-09-11. Selected-card identity does not imply clinical verification.