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1 local source card selected. Local card fingerprints checked where supplied. This is not an original-document hash, source-currency guarantee or clinical approval. Record-level cautions below are the current library's cautions, not a frozen prior version.
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Clinical context remains essential
Independent clinical review is pending. Confirm indication, exact formulation/route, population, renal measure and units, kidney-function stability, dialysis prescription, interacting drugs, monitoring and source revision. An RX mirror and its original label are not independent corroboration. Missing disagreement notes do not certify agreement.
The historical renal cutoff is preserved. Current product labeling and professional recommendations may use different thresholds; do not silently reconcile them.
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MACROBID renal contraindication - selected label
Product / population
MACROBID nitrofurantoin monohydrate/macrocrystals, oral. Selected restriction, not a complete antibiotic regimen.
Renal method
CrCl, mL/min, plus qualitative anuria/oliguria and serum-creatinine criteria.
Source revision
Source revision date not established in selected retrieval.
Retrieved
2026-09-07
Local review status
Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph.
Documented differences and cautions on this drug
All record notes are retained here, including notes about sources not selected in this review.
MACROBID label and older-adult criteria use different renal thresholds
The label retains a CrCl-below-60 contraindication; the AGS 2023 older-adult criterion uses below 30. This difference does not establish safety for every patient between those values.
What to reconcile: Confirm population, lower-tract indication, duration and local policy. Document any departure from labeling; neither a source count nor this comparison selects a prescription.
Nitrofurantoin: U.K. indexed-eGFR advice is not the U.S. CrCl label
The added historical MHRA advice differs in renal measure, cutoff and limited lower-UTI exception from the retained U.S. label and geriatric/institutional sources. It is not a new 2026 U.S. rule.
What to reconcile: Keep jurisdiction, infection site, source date and renal estimator attached to each recommendation. Do not substitute one numerical cutoff for another without clinical adjudication.
Nitrofurantoin: label, UCSF and UK guidance remain distinct
The label restriction, UCSF limited-data position and UK short-course exception differ in renal measure, setting and qualifications. UCSF is not an endorsement down to CrCl 30.
What to reconcile: Document jurisdiction and infection scope; preserve the UK multidrug-resistant lower-UTI and benefit-risk qualifications. Do not convert eGFR thresholds into CrCl cutoffs.
DailyMed / NLM; manufacturer prescribing information · MACROBID nitrofurantoin monohydrate/macrocrystals, oral. Selected restriction, not a complete antibiotic regimen.
Renal method: CrCl, mL/min, plus qualitative anuria/oliguria and serum-creatinine criteria. Source date: Source revision date not established in selected retrieval. Retrieved: 2026-09-07
Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.
Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph.
Renal dosing, restrictions and evidence limits
The selected MACROBID label contraindicates use with anuria, oliguria or significant renal impairment, including CrCl below 60 mL/min or clinically important serum-creatinine elevation. It identifies increased toxicity from impaired excretion. Monitor renal function with long-term treatment; pulmonary, hepatic and peripheral-neuropathy risks remain relevant. This label restriction differs from the separately displayed older-adult professional criterion.
This reference does not select a regimen. Complete the indication, measured/estimated renal function and trend, dialysis setting, source rationale, monitoring and reassessment plan in your institution's approved documentation system. Confirm the complete current source before adopting its regimen.
GlobalRPh v6.6 | RDM66-DIRECT-PHP-20260911 | Local library date 2026-09-11. Selected-card identity does not imply clinical verification.