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Quetiapine immediate-release tablets (adults) - selected U.S. labeling
Product / population
Adult bipolar depression dosing orientation with oral immediate-release quetiapine tablets. Excludes extended-release tablets and other indication-specific titrations.
Renal method
Indexed ClCr in the renal study; no labeled numeric renal reduction.
Source revision
Label revision date not separately recorded; retrieval date is not the revision date.
Retrieved
2026-09-05
Local review status
Selected dosing/renal sections read; concise local summary, not full prescribing information.
Official
Quetiapine immediate-release tablets (adults) - selected U.S. labeling
U.S. product labeling / DailyMed · Adult bipolar depression dosing orientation with oral immediate-release quetiapine tablets. Excludes extended-release tablets and other indication-specific titrations.
Renal method: Indexed ClCr in the renal study; no labeled numeric renal reduction. Source date: Label revision date not separately recorded; retrieval date is not the revision date. Retrieved: 2026-09-05
Selected dosing/renal sections read; concise local summary, not full prescribing information.
Labeled basic dosing
For adult bipolar depression, the label gives once-nightly doses of 50 mg on day 1, 100 mg on day 2, 200 mg on day 3 and 300 mg on day 4; recommended dose 300 mg/day.
At ClCr 10-30 mL/min/1.73 m2, mean clearance was about 25% lower, but exposures remained within the normal-subject range. The label therefore does not require renal adjustment for those patients. A separate dialysis regimen is not established here.
Older adults and hepatic impairment have separate dosing considerations. Review orthostasis, sedation, metabolic adverse effects, suicidality and the boxed warning about mortality in elderly patients with dementia-related psychosis.
This reference does not select a regimen. Complete the indication, measured/estimated renal function and trend, dialysis setting, source rationale, monitoring and reassessment plan in your institution's approved documentation system. Confirm the complete current source before adopting its regimen.
GlobalRPh v6.6 | RDM66-DIRECT-PHP-20260911 | Local library date 2026-09-11. Selected-card identity does not imply clinical verification.