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Clinical context remains essential
Independent clinical review is pending. Confirm indication, exact formulation/route, population, renal measure and units, kidney-function stability, dialysis prescription, interacting drugs, monitoring and source revision. An RX mirror and its original label are not independent corroboration. Missing disagreement notes do not certify agreement.
The source summary and source table use slightly different boundary notation at CrCl 30. The original indexed table heading and accompanying Cockcroft-Gault formula are retained; renal-function normalization must be confirmed before prescribing.
Adult institutional antimicrobial dosing; standard and separately ID-directed CRAB pathways.
Renal method
CrCl in mL/min; intermittent versus continuous hemodialysis; source-specific boundaries
Source revision
Source revision date not established in selected retrieval.
Retrieved
2026-09-07
Local review status
Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph.
Documented differences and cautions on this drug
All record notes are retained here, including notes about sources not selected in this review.
UNASYN label and UCSF do not use identical renal bands
At the printed value 30, the RX label table places patients in its at-least-30 row, whereas UCSF standard dosing places 30 in its 15-30 row. The RX heading also prints indexed clearance while UCSF uses mL/min.
What to reconcile: Reconcile the renal metric and endpoint before selecting an interval. Do not choose whichever row is more convenient or merge the label dose range with an institutional interval.
High-dose CRAB treatment is not the routine label regimen
The ID-directed UCSF CRAB regimen can exceed the routine labeled sulbactam exposure. It has different infusion duration and renal eligibility, and its printed extended-infusion columns leave exactly 60 unassigned.
What to reconcile: Use infectious-disease/antimicrobial-stewardship oversight and the exact infection context. Do not extrapolate this row into unlisted renal or dialysis settings. Keep total combination grams distinct from sulbactam grams.
UCSF Infectious Diseases Management Program · Adult institutional antimicrobial dosing; standard and separately ID-directed CRAB pathways.
Renal method: CrCl in mL/min; intermittent versus continuous hemodialysis; source-specific boundaries Source date: Source revision date not established in selected retrieval. Retrieved: 2026-09-07
Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.
Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph.
Renal dosing, restrictions and evidence limits
UCSF standard adult IV dosing is 3 g every six hours for CrCl above 30 mL/min, every 12 hours at 15-30, and every 24 hours below 15. Its intermittent-hemodialysis regimen is 3 g IV every 12 hours; continuous-hemodialysis dosing is 3 g IV every six hours. For carbapenem-resistant Acinetobacter baumannii, the separate ID-directed extended-infusion row lists 9 g IV every eight hours over four hours only above CrCl 60; lower categories require ID/antimicrobial-stewardship pharmacy guidance. The printed extended-infusion columns leave exactly 60 unassigned. These are total combination grams. Do not extrapolate the specialized regimen into unlisted renal settings or treat all CRRT prescriptions as identical.
This reference does not select a regimen. Complete the indication, measured/estimated renal function and trend, dialysis setting, source rationale, monitoring and reassessment plan in your institution's approved documentation system. Confirm the complete current source before adopting its regimen.
GlobalRPh v6.6 | RDM66-DIRECT-PHP-20260911 | Local library date 2026-09-11. Selected-card identity does not imply clinical verification.