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Clinical context remains essential
Independent clinical review is pending. Confirm indication, exact formulation/route, population, renal measure and units, kidney-function stability, dialysis prescription, interacting drugs, monitoring and source revision. An RX mirror and its original label are not independent corroboration. Missing disagreement notes do not certify agreement.
Compare complete versions: U.S. labeling uses 2-hour infusions, while UCSF uses 3-hour extended infusions. Nebraska separately lists an HD/PD interval different from the label. Do not select a dose from one version and an interval from another.
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Avycaz - labeled renal guidance
Product / population
Ceftazidime/avibactam (Avycaz), adult IV combination
Renal method
Cockcroft-Gault creatinine clearance, mL/min
Source revision
DailyMed SPL version 25, effective 2025-04-30; posted Aug 11, 2026
All record notes are retained here, including notes about sources not selected in this review.
Avycaz - product and source limitations
The FDA label uses a 2-hour infusion. UCSF reports 3 hours and a separate institutional dialysis schedule. Select a complete source before using a dose.
What to reconcile: The FDA label uses a 2-hour infusion. UCSF reports 3 hours and a separate institutional dialysis schedule. Select a complete source before using a dose.
Give after hemodialysis on HD days. Reassess CrCl at least daily when it is changing. Pediatric eGFR bands have a separate table.
Adult renal dosing in this source
CrCl (mL/min)
Total IV combination dose over 2 hours
Interval
31-50
1.25 g
Every 8 hours
16-30
0.94 g
Every 12 hours
6-15
0.94 g
Every 24 hours
<=5
0.94 g
Every 48 hours
Read the retained text before reformatting
Adult renal doses are total combination grams infused over 2 hours. CrCl 31-50: 1.25 g every 8 hours. At 16-30: 0.94 g every 12 hours. At 6-15: 0.94 g every 24 hours. At <=5: 0.94 g every 48 hours. Give after hemodialysis on HD days. Reassess CrCl at least daily when it is changing. Pediatric eGFR bands have a separate table.
This reference does not select a regimen. Complete the indication, measured/estimated renal function and trend, dialysis setting, source rationale, monitoring and reassessment plan in your institution's approved documentation system. Confirm the complete current source before adopting its regimen.
GlobalRPh Renal Dosing Master v7.4. Review the retrieval and revision dates attached to each source. Selecting a reference does not imply clinical verification.