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Mektovi - labeled renal guidance
Product / population
Binimetinib (Mektovi), adult oral tablets
Renal method
Indexed GFR/eGFR, mL/min/1.73 m2
Source revision
DailyMed SPL version 12, effective 2025-03-20; posted Mar 24, 2025
Renal guidance: 12.3 and 2, dosage modifications for adverse reactions
In severe renal impairment (eGFR <=29 mL/min/1.73 m2), systemic exposure did not change to a clinically important degree in the cited study. Separately, renal impairment with elevated CPK can require withholding treatment. Check the adverse-reaction table before continuing therapy.
RDM73-mektovi-official-1 · Source locator: Renal guidance: 12.3 and 2, dosage modifications for adverse reactions
This reference does not select a regimen. Complete the indication, measured/estimated renal function and trend, dialysis setting, source rationale, monitoring and reassessment plan in your institution's approved documentation system. Confirm the complete current source before adopting its regimen.
GlobalRPh Renal Dosing Master v7.4. Review the retrieval and revision dates attached to each source. Selecting a reference does not imply clinical verification.
