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Cosela - labeled renal guidance
Product / population
Trilaciclib (Cosela), adult IV infusion before eligible chemotherapy
Renal method
Indexed GFR/eGFR, mL/min/1.73 m2
Source revision
DailyMed SPL version 3, effective 2025-08-31; posted Sep 10, 2025
At eGFR 30-89 mL/min/1.73 m2, the PK analysis found no clinically meaningful change in exposure. Severe renal impairment, ESRD and dialysis were unstudied. The PK finding supplies no regimen for these groups.
RDM73-cosela-official-1 · Source locator: Renal guidance: 12.3, specific populations
This reference does not select a regimen. Complete the indication, measured/estimated renal function and trend, dialysis setting, source rationale, monitoring and reassessment plan in your institution's approved documentation system. Confirm the complete current source before adopting its regimen.
GlobalRPh Renal Dosing Master v7.4. Review the retrieval and revision dates attached to each source. Selecting a reference does not imply clinical verification.
