GlobalRPh Renal Dosing Masterv6.6
Source review / handoff

Belumosudil - REZUROCK oral tablets

One or two intact local summaries. No averaged regimen, patient-specific dose or automatic source preference.

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1 local source card selected. Local card fingerprints checked where supplied. This is not an original-document hash, source-currency guarantee or clinical approval. Record-level cautions below are the current library's cautions, not a frozen prior version.

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Clinical context remains essential

Independent clinical review is pending. Confirm indication, exact formulation/route, population, renal measure and units, kidney-function stability, dialysis prescription, interacting drugs, monitoring and source revision. An RX mirror and its original label are not independent corroboration. Missing disagreement notes do not certify agreement.

Check source scope before reading a dose

Belumosudil - REZUROCK oral tablets

Product / population
Age 12 years and older; chronic GVHD after at least two prior systemic treatments.
Renal method
eGFR: PK paragraph prints mL/min/1.72 m2; trial exclusion prints 1.73 m2.
Source revision
01/2026
Retrieved
2026-09-10
Local review status
Selected source sections stored locally. Not a complete monograph or independent clinical approval.

Documented differences and cautions on this drug

All record notes are retained here, including notes about sources not selected in this review.

Before use: Belumosudil - REZUROCK oral tablets

Both the mirror and manufacturer print 1.72 m2 for renal PK; the manufacturer also uses 1.73 m2 for trial exclusion. This is not an isolated mirror transcription error.

What to reconcile: Do not normalize the unusual units or infer a severe-renal regimen. Check the exact product, interactions and full labeling.

Source-specific interpretation; independent clinician adjudication pending.

Open this note and its source references
Official

Belumosudil - REZUROCK oral tablets

Open original reference

Sanofi / manufacturer prescribing information · Age 12 years and older; chronic GVHD after at least two prior systemic treatments.

Renal method: eGFR: PK paragraph prints mL/min/1.72 m2; trial exclusion prints 1.73 m2.
Source date: 01/2026
Retrieved: 2026-09-10

Pharmacokinetic observation only. A drug-exposure observation is not itself a dose recommendation.
Before using this finding

Do not normalize the unusual units or infer a severe-renal regimen. Check the exact product, interactions and full labeling.

Selected source sections stored locally. Not a complete monograph or independent clinical approval.

Renal guidance and important limits

Limits that apply to these rows

The usual dose is 200 mg orally once daily with food. No severe-renal dose or dialysis supplement is established here.

The source prints 1.72 m2 in its PK paragraph. Do not silently substitute another renal measure. Interaction, hepatic and embryo-fetal safeguards still apply; monitor bilirubin, AST and ALT at least monthly.

REZUROCK - renal evidence, not a dose ladder
Source renal populationSource-specific instruction
eGFR >=60 to <90 and >=30 to <60 (printed per 1.72 m2)No clinically significant pharmacokinetic difference reported.
Pre-existing severe renal impairmentNot studied; weigh risks and benefits before starting.
Read the retained text before reformatting

REZUROCK - renal evidence, not a dose ladder

Source renal populationSource-specific instruction
eGFR >=60 to <90 and >=30 to <60 (printed per 1.72 m2)No clinically significant pharmacokinetic difference reported.
Pre-existing severe renal impairmentNot studied; weigh risks and benefits before starting.

The usual dose is 200 mg orally once daily with food. No severe-renal dose or dialysis supplement is established here.

The source prints 1.72 m2 in its PK paragraph. Do not silently substitute another renal measure. Interaction, hepatic and embryo-fetal safeguards still apply; monitor bilirubin, AST and ALT at least monthly.

RDM64-official-belumosudil-rezurock-a7ba1181bc-C1 · Source locator: Sections 2.1-2.3, 8.6, 12.3, 14.1; manufacturer PDF pages 1, 3 and 4 inspected.

Source-specific limits

The usual dose is 200 mg orally once daily with food. No severe-renal dose or dialysis supplement is established here.

The source prints 1.72 m2 in its PK paragraph. Do not silently substitute another renal measure. Interaction, hepatic and embryo-fetal safeguards still apply; monitor bilirubin, AST and ALT at least monthly.

Source identity and provenance
Source family
product_label
Source
https://products.sanofi.us/rezurock/rezurock.pdf
Retrieved
2026-09-10
Exact label title
Belumosudil - REZUROCK oral tablets
Label revision
01/2026
Renal-function method
eGFR: PK paragraph prints mL/min/1.72 m2; trial exclusion prints 1.73 m2.
Source date/version
01/2026
Hash meaning
Local authored summary, not source HTML/XML/PDF bytes
Local summary SHA-256
bea3e3adecd76ba50fda00aa916e4d8bc10d6a522ee59cb5f5049356645817dc

Document the clinical decision separately

This reference does not select a regimen. Complete the indication, measured/estimated renal function and trend, dialysis setting, source rationale, monitoring and reassessment plan in your institution's approved documentation system. Confirm the complete current source before adopting its regimen.

GlobalRPh v6.6 | RDM66-DIRECT-PHP-20260911 | Local library date 2026-09-11. Selected-card identity does not imply clinical verification.

Pinned reference: https://globalrph.com/blogCalcs/renal-dosing-master/compare.php?id=belumosudil-rezurock&s1=RDM64-official-belumosudil-rezurock-a7ba1181bc&h1=afb7712d054688ce15cf40691edec5b617fcabed46bd7dde1120ade0cfbbf395