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1 local source card selected. Local card fingerprints checked where supplied. This is not an original-document hash, source-currency guarantee or clinical approval. Record-level cautions below are the current library's cautions, not a frozen prior version.
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Clinical context remains essential
Independent clinical review is pending. Confirm indication, exact formulation/route, population, renal measure and units, kidney-function stability, dialysis prescription, interacting drugs, monitoring and source revision. An RX mirror and its original label are not independent corroboration. Missing disagreement notes do not certify agreement.
Check source scope before reading a dose
Belumosudil - REZUROCK oral tablets
Product / population
Age 12 years and older; chronic GVHD after at least two prior systemic treatments.
Renal method
eGFR: PK paragraph prints mL/min/1.72 m2; trial exclusion prints 1.73 m2.
Source revision
01/2026
Retrieved
2026-09-10
Local review status
Selected source sections stored locally. Not a complete monograph or independent clinical approval.
Documented differences and cautions on this drug
All record notes are retained here, including notes about sources not selected in this review.
Before use: Belumosudil - REZUROCK oral tablets
Both the mirror and manufacturer print 1.72 m2 for renal PK; the manufacturer also uses 1.73 m2 for trial exclusion. This is not an isolated mirror transcription error.
What to reconcile: Do not normalize the unusual units or infer a severe-renal regimen. Check the exact product, interactions and full labeling.
Sanofi / manufacturer prescribing information · Age 12 years and older; chronic GVHD after at least two prior systemic treatments.
Renal method: eGFR: PK paragraph prints mL/min/1.72 m2; trial exclusion prints 1.73 m2. Source date: 01/2026 Retrieved: 2026-09-10
Pharmacokinetic observation only. A drug-exposure observation is not itself a dose recommendation.
Before using this finding
Do not normalize the unusual units or infer a severe-renal regimen. Check the exact product, interactions and full labeling.
Selected source sections stored locally. Not a complete monograph or independent clinical approval.
Renal guidance and important limits
Limits that apply to these rows
The usual dose is 200 mg orally once daily with food. No severe-renal dose or dialysis supplement is established here.
The source prints 1.72 m2 in its PK paragraph. Do not silently substitute another renal measure. Interaction, hepatic and embryo-fetal safeguards still apply; monitor bilirubin, AST and ALT at least monthly.
REZUROCK - renal evidence, not a dose ladder
Source renal population
Source-specific instruction
eGFR >=60 to <90 and >=30 to <60 (printed per 1.72 m2)
No clinically significant pharmacokinetic difference reported.
Pre-existing severe renal impairment
Not studied; weigh risks and benefits before starting.
Read the retained text before reformatting
REZUROCK - renal evidence, not a dose ladder
Source renal population
Source-specific instruction
eGFR >=60 to <90 and >=30 to <60 (printed per 1.72 m2)
No clinically significant pharmacokinetic difference reported.
Pre-existing severe renal impairment
Not studied; weigh risks and benefits before starting.
The usual dose is 200 mg orally once daily with food. No severe-renal dose or dialysis supplement is established here.
The source prints 1.72 m2 in its PK paragraph. Do not silently substitute another renal measure. Interaction, hepatic and embryo-fetal safeguards still apply; monitor bilirubin, AST and ALT at least monthly.
RDM64-official-belumosudil-rezurock-a7ba1181bc-C1 · Source locator: Sections 2.1-2.3, 8.6, 12.3, 14.1; manufacturer PDF pages 1, 3 and 4 inspected.
Source-specific limits
The usual dose is 200 mg orally once daily with food. No severe-renal dose or dialysis supplement is established here.
The source prints 1.72 m2 in its PK paragraph. Do not silently substitute another renal measure. Interaction, hepatic and embryo-fetal safeguards still apply; monitor bilirubin, AST and ALT at least monthly.
This reference does not select a regimen. Complete the indication, measured/estimated renal function and trend, dialysis setting, source rationale, monitoring and reassessment plan in your institution's approved documentation system. Confirm the complete current source before adopting its regimen.
GlobalRPh v6.6 | RDM66-DIRECT-PHP-20260911 | Local library date 2026-09-11. Selected-card identity does not imply clinical verification.