One or two intact local summaries. No averaged regimen, patient-specific dose or automatic source preference.
1 local source card selected. Local card fingerprints checked where supplied. This is not an original-document hash, source-currency guarantee or clinical approval. Record-level cautions below are the current library's cautions, not a frozen prior version.
Independent clinical review is pending. Confirm indication, exact formulation/route, population, renal measure and units, kidney-function stability, dialysis prescription, interacting drugs, monitoring and source revision. An RX mirror and its original label are not independent corroboration. Missing disagreement notes do not certify agreement.
Historical indication-specific regimens are preserved. Penicillin G potassium, benzathine penicillin G and oral penicillin VK are not interchangeable formulations.
Selected serious-infection rows agree with the retained UCSF summary; source-specific doses remain separate from other evidence.
What to reconcile: Choose the indication, potassium/sodium formulation and dialysis setting; do not use these schedules for benzathine or procaine penicillin.
Open this note and its source referencesAssess potassium load; sodium penicillin G may be preferable when available. Do not transfer to benzathine or procaine products.
| CrCl, mL/min | Source-specific dose / instruction |
|---|---|
| >50 | 4 million units every 4 hours |
| 10-50 | 3 million units every 4 hours |
| <10 | 3 million units every 6 hours |
| CrCl, mL/min | Source-specific dose / instruction |
|---|---|
| >50 | 3 million units every 4 hours |
| 10-50 | 3 million units every 6 hours |
| <10 | 2 million units every 6 hours |
| Dialysis setting / indication | Source-specific schedule |
|---|---|
| Intermittent HD - neurosyphilis/meningitis/necrotizing infection/toxic shock | 4 million units once, then 2 million units every 4 hours |
| Continuous HD - same indications | 3 million units every 4 hours |
| Intermittent HD - endovascular infection/bacteremia | 3 million units once, then 2 million units every 6 hours |
| Continuous HD - endovascular infection/bacteremia | 3 million units every 6 hours |
For neurosyphilis, meningitis, necrotizing skin infection or toxic shock, CrCl >50 / 10-50 / <10 mL/min: 4 million units every 4 hours / 3 million every 4 hours / 3 million every 6 hours, all IV. IHD: 4 million units initially, then 2 million every 4 hours. Continuous HD: 3 million every 4 hours.
For endovascular infection or bacteremia, corresponding non-dialysis schedules are 3 million every 4 hours / 3 million every 6 hours / 2 million every 6 hours. IHD: 3 million initially then 2 million every 6 hours; continuous HD: 3 million every 6 hours.
Assess potassium load; sodium penicillin G may be preferable when available. Do not transfer to benzathine or procaine products.
RDM30-056-penicillin-g-1 · Source locator: UCSF - aqueous penicillin G potassium IV; renal/dosing sections and stated qualifiers
This reference does not select a regimen. Complete the indication, measured/estimated renal function and trend, dialysis setting, source rationale, monitoring and reassessment plan in your institution's approved documentation system. Confirm the complete current source before adopting its regimen.
Pinned reference: https://globalrph.com/blogCalcs/renal-dosing-master/compare.php?id=penicillin-g&s1=RDM30-056-penicillin-g&h1=aa81b838a59994b46d387ccf03c24e2c9811d3b79ffe0f078d1f1e7db3b008d4