GlobalRPh Renal Dosing Masterv6.6
Source review / handoff

Clarithromycin

One or two intact local summaries. No averaged regimen, patient-specific dose or automatic source preference.

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1 local source card selected. Local card fingerprints checked where supplied. This is not an original-document hash, source-currency guarantee or clinical approval. Record-level cautions below are the current library's cautions, not a frozen prior version.

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Clinical context remains essential

Independent clinical review is pending. Confirm indication, exact formulation/route, population, renal measure and units, kidney-function stability, dialysis prescription, interacting drugs, monitoring and source revision. An RX mirror and its original label are not independent corroboration. Missing disagreement notes do not certify agreement.

Historical H. pylori regimens, the pediatric weight table and lifelong MAC statement are preserved from the source; they are not independently verified current treatment recommendations. IR and XL are distinct formulations.

The handbook renal dose ranges and selected U.S. label dose-reduction rules differ. Current label instructions and patient-specific interactions must be reviewed; the sources are not counted as agreeing.

Check source scope before reading a dose

Clarithromycin immediate-release tablets, USP

Product / population
Adult oral immediate-release tablets; not an IV or extended-release regimen.
Renal method
Not specified
Source revision
Retrieved
2026-09-05
Local review status
Source-read local summary; source-specific recommendations are not automatically interchangeable.
Official

Clarithromycin immediate-release tablets, USP

Open original reference

NIH/NLM DailyMed - U.S. prescribing information · Adult oral immediate-release tablets; not an IV or extended-release regimen.

Renal method: Not specified in this summary.
Source date:
Retrieved: 2026-09-05

Source-read local summary; source-specific recommendations are not automatically interchangeable.

Baseline adult examples

Sinusitis: 500 mg every 12 hours for 14 days. Community-acquired pneumonia: 250 mg every 12 hours for 7-14 days. For disseminated MAC treatment, 500 mg every 12 hours with other antimycobacterial agents. These are label regimens, not endorsement as current empiric first-line choices.

clarithromycin:dm-98580dee-d2f4-4f62-a2d4-7434bab2421e-1 · Source locator: 2.2, Table 1; 2.5

Renal impairment and interactions

At CrCl <30 mL/min, reduce the selected dose by 50%. With atazanavir or a ritonavir-containing regimen, the renal table calls for a 50% reduction at CrCl 30-60 and a 75% reduction below 30. Atazanavir itself requires a 50% reduction. Do not combine independently calculated reductions.

clarithromycin:dm-98580dee-d2f4-4f62-a2d4-7434bab2421e-2 · Source locator: 2.6, Table 2; 2.7

High-risk combination

Concomitant colchicine is contraindicated in renal or hepatic impairment. Review the complete interaction and QT-risk warnings before selecting therapy.

clarithromycin:dm-98580dee-d2f4-4f62-a2d4-7434bab2421e-3 · Source locator: 4.4; 5.2; 7

Source identity and provenance
Source
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=98580dee-d2f4-4f62-a2d4-7434bab2421e
Retrieved
2026-09-05
Exact label title
Clarithromycin immediate-release tablets, USP
DailyMed Set ID
98580dee-d2f4-4f62-a2d4-7434bab2421e
Labeler
Ajanta Pharma USA Inc.
DailyMed page updated
2023-12-05
FDA application
Abbreviated New Drug Application
U.S. product identity basis
Exact named product and route appear in the selected U.S. prescription label; current retail availability was not independently assessed.
Hash meaning
Locally authored source summary, not original SPL/XML/PDF bytes
Local summary SHA-256
6cae6e371b2e896b7bfd9637296a42fb522296fc33a1cf26e8a14bd70e4096c9

Document the clinical decision separately

This reference does not select a regimen. Complete the indication, measured/estimated renal function and trend, dialysis setting, source rationale, monitoring and reassessment plan in your institution's approved documentation system. Confirm the complete current source before adopting its regimen.

GlobalRPh v6.6 | RDM66-DIRECT-PHP-20260911 | Local library date 2026-09-11. Selected-card identity does not imply clinical verification.

Pinned reference: https://globalrph.com/blogCalcs/renal-dosing-master/compare.php?id=clarithromycin&s1=dm-98580dee-d2f4-4f62-a2d4-7434bab2421e&h1=a904c68455ab18ab19761fdc990683d809b4cd67a1bafa0f4b6311a180998967