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Clinical context remains essential
Independent clinical review is pending. Confirm indication, exact formulation/route, population, renal measure and units, kidney-function stability, dialysis prescription, interacting drugs, monitoring and source revision. An RX mirror and its original label are not independent corroboration. Missing disagreement notes do not certify agreement.
This complete historical IV source is not a contemporary AUC, neonatal, unstable-AKI or high-flux-HD dosing algorithm. Its low-flux statement must not be generalized to modern HD. Original nomogram calculations and target concentrations are not enabled as automated recommendations.
2020 consensus executive summary for serious invasive MRSA infections; not a universal target for all organisms or oral therapy.
Renal method
AUC24-based exposure assessment, renal reassessment and renal-replacement context.
Source revision
March 19, 2020; DOI 10.1093/ajhp/zxaa036.
Retrieved
2026-09-07
Local review status
Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph.
Documented differences and cautions on this drug
All record notes are retained here, including notes about sources not selected in this review.
Historical renal nomogram versus later serious-MRSA exposure monitoring
The 2015 RX label mirror preserves an older steady-state renal nomogram and anuric approach. The 2020 multi-society executive summary favors AUC-guided monitoring for serious invasive MRSA, rather than reliance on trough surrogates or a fixed renal estimate alone.
What to reconcile: Use measured exposure, current renal function and the actual dialysis prescription with local monitoring capability. The consensus target is indication-scoped and is not a new fixed dose, oral-vancomycin rule or universal replacement-therapy schedule.
ASHP / IDSA / PIDS / SIDP · 2020 consensus executive summary for serious invasive MRSA infections; not a universal target for all organisms or oral therapy.
Renal method: AUC24-based exposure assessment, renal reassessment and renal-replacement context. Source date: March 19, 2020; DOI 10.1093/ajhp/zxaa036. Retrieved: 2026-09-07
Renal toxicity or monitoring. On-treatment injury and monitoring instructions are not a baseline renal-dose schedule.
Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph.
Renal dosing, restrictions and evidence limits
The consensus favors an AUC24 target of 400-600 mg*h/L when the broth-microdilution MIC is assumed to be 1 mg/L, seeking target attainment within 24-48 hours. Prior trough-surrogate strategies were associated with greater nephrotoxicity. Actual-body-weight loading is suggested for critically ill patients, those on renal replacement, or continuous infusion. These principles do not provide a universal fixed renal interval or a dialysis prescription. The complete selected-source review is needed alongside local monitoring capability and the patient's changing renal status. This dated executive-summary supplement is not a full re-review of every consensus table.
RDM40-professional-vancomycin-aee0ed3805-C1 · Source locator: Abstract and executive summary on IDSA site
This reference does not select a regimen. Complete the indication, measured/estimated renal function and trend, dialysis setting, source rationale, monitoring and reassessment plan in your institution's approved documentation system. Confirm the complete current source before adopting its regimen.
GlobalRPh v6.6 | RDM66-DIRECT-PHP-20260911 | Local library date 2026-09-11. Selected-card identity does not imply clinical verification.