GlobalRPh Renal Dosing Masterv6.6
Source review / handoff

Daptomycin

One or two intact local summaries. No averaged regimen, patient-specific dose or automatic source preference.

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Selecting here opens the current stored cards. The pinned link below records their fingerprints. Do not enter patient information in links or searches.

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1 local source card selected. Local card fingerprints checked where supplied. This is not an original-document hash, source-currency guarantee or clinical approval. Record-level cautions below are the current library's cautions, not a frozen prior version.

Copy is optional; the link can be selected and copied manually. No patient data or dose decision is collected.

Clinical context remains essential

Independent clinical review is pending. Confirm indication, exact formulation/route, population, renal measure and units, kidney-function stability, dialysis prescription, interacting drugs, monitoring and source revision. An RX mirror and its original label are not independent corroboration. Missing disagreement notes do not certify agreement.

Check source scope before reading a dose

Nebraska Medicine daptomycin

Product / population
Adult IV; exact displayed source row reviewed visually.
Renal method
Not specified
Source revision
Not independently captured
Retrieved
2026-09-05
Local review status
Source-read local summary; source-specific recommendations are not automatically interchangeable.

Documented differences and cautions on this drug

All record notes are retained here, including notes about sources not selected in this review.

Do not merge label and higher-dose institutional dialysis protocols

The label includes CrCl exactly 30 in its >=30 band. UCSF prints >30 and <30, omitting exactly 30, and uses higher doses and different HD scheduling.

What to reconcile: Keep source-specific dose, interval, indication, weight basis and modality together. The official threshold is explicit; seek institutional clarification rather than silently changing its headings.

Source-specific interpretation; independent clinician adjudication pending.

Open this note and its source references
Professional

Nebraska Medicine daptomycin

Open original reference

UNMC / Nebraska Medicine · Adult IV; exact displayed source row reviewed visually.

Renal method: Not specified in this summary.
Source date: Not independently captured
Retrieved: 2026-09-05

Source recheck unresolved. Prior follow-up retrieval/version warning retained; not resolved by v6.0. Read source-review status

Source-read local summary; source-specific recommendations are not automatically interchangeable.

Adult regimen and renal adjustment

The displayed table uses 6 mg/kg IV daily for bacteremia, osteomyelitis and other severe infections, or 4 mg/kg daily for UTI/skin infection. At CrCl <30 mL/min it retains the selected dose but extends the interval to every 48 hours. HD follows the <30 interval, with administration after dialysis on treatment days.

daptomycin:unmc-daptomycin-1 · Source locator: Rendered PDF page 21: daptomycin row

Source-specific limits

This institutional source includes off-label indications. Its outpatient post-HD and higher-dose salvage options were not imported here. Parsed-text page numbers did not match the rendered PDF; this summary uses the displayed page, not the conflicting parsed locations.

Source identity and provenance
Source
https://www.unmc.edu/intmed/_documents/id/asp/dose-nm-anti-infective-renal-dosing-guidelines.pdf
Retrieved
2026-09-05
Source date/version
Not independently captured
Hash meaning
Locally authored source summary, not original SPL/XML/PDF bytes
Local summary SHA-256
2a46f7b947eba7f903f11ef28837c73a2e59dc6c43cd3edaff3fb65c179c700c

Document the clinical decision separately

This reference does not select a regimen. Complete the indication, measured/estimated renal function and trend, dialysis setting, source rationale, monitoring and reassessment plan in your institution's approved documentation system. Confirm the complete current source before adopting its regimen.

GlobalRPh v6.6 | RDM66-DIRECT-PHP-20260911 | Local library date 2026-09-11. Selected-card identity does not imply clinical verification.

Pinned reference: https://globalrph.com/blogCalcs/renal-dosing-master/compare.php?id=daptomycin&s1=unmc-daptomycin&h1=a437f9f166135bb22fee1b4621dc998f7c0e06c314557f7a13411435d179c146