GlobalRPh Renal Dosing Masterv7.4
Renal Dosing Master: fast drug lookup
Source review / handoff

Canagliflozin/metformin (Invokamet), adult immediate-release oral tablets

One or two intact local summaries. No averaged regimen, patient-specific dose or automatic source preference.

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1 local source card selected. Local card fingerprints checked where supplied. This is not an original-document hash, source-currency guarantee or clinical approval. Record-level cautions below are the current library's cautions, not a frozen prior version.

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Clinical context remains essential

Independent clinical review is pending. Confirm indication, exact formulation/route, population, renal measure and units, kidney-function stability, dialysis prescription, interacting drugs, monitoring and source revision. An RX mirror and its original label are not independent corroboration. Missing disagreement notes do not certify agreement.

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Invokamet - labeled renal guidance

Product / population
Canagliflozin/metformin (Invokamet), adult immediate-release oral tablets
Renal method
Indexed GFR/eGFR, mL/min/1.73 m2
Source revision
DailyMed SPL version 32, effective 2026-08-24; posted Aug 25, 2026
Retrieved
2026-11-07
Local review status
Selected renal passages reviewed; independent clinician adjudication pending.

Documented differences and cautions on this drug

All record notes are retained here, including notes about sources not selected in this review.

Invokamet - product and source limitations

These rules apply to a metformin-containing combination. Confirm the immediate-release formulation, interactions and contrast instructions.

What to reconcile: Apply only to the stated formulation, indication and renal population.

Selected renal passages reviewed; independent clinician adjudication pending.

Open this note and its source references
Official

Invokamet - labeled renal guidance

Open original reference

DailyMed / product prescribing information · Canagliflozin/metformin (Invokamet), adult immediate-release oral tablets

Renal method: Indexed GFR/eGFR, mL/min/1.73 m2
Source date: DailyMed SPL version 32, effective 2026-08-24; posted Aug 25, 2026
Retrieved: 2026-11-07

Restriction or avoidance guidance. Read the specific threshold, age, formulation and dialysis exclusions; do not generalize across products.

Selected renal passages reviewed; independent clinician adjudication pending.

Renal guidance: 2.3, Table 2

Below eGFR 45, initiation is not recommended. At 45 to <60, the renal table caps canagliflozin at 100 mg/day. At 30 to <45, reassess continuation and use the same cap. Below 30, discontinue; use is contraindicated. These rules apply to a metformin-containing combination. Confirm the immediate-release formulation, interactions and contrast instructions.

RDM73-invokamet-official-1 · Source locator: Renal guidance: 2.3, Table 2

Source identity and provenance
Source family
product_label
Source
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=6868666b-c25e-40d1-9d1f-306bbe9390c1
Retrieved
2026-11-07
Renal-function method
Indexed GFR/eGFR, mL/min/1.73 m2
Source date/version
DailyMed SPL version 32, effective 2026-08-24; posted Aug 25, 2026
Hash meaning
SHA-256 of the local selected-source summary
Local summary SHA-256
c408f7920333b3824cb4efdf09f339f1eba1ca4680862d08afb81977ec1dcdb7

Document the clinical decision separately

This reference does not select a regimen. Complete the indication, measured/estimated renal function and trend, dialysis setting, source rationale, monitoring and reassessment plan in your institution's approved documentation system. Confirm the complete current source before adopting its regimen.

GlobalRPh Renal Dosing Master v7.4. Review the retrieval and revision dates attached to each source. Selecting a reference does not imply clinical verification.

Pinned reference: https://globalrph.com/blogCalcs/renal-dosing-master/compare.php?id=canagliflozin-metformin-invokamet&s1=RDM73-invokamet-official&h1=9a6bdfefc30e82277d94e86034ae8770e5f44ba358ef5a27ee6ed306ee7af313

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