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Epivir - labeled renal guidance
Product / population
Lamivudine (Epivir), oral HIV treatment; adults and adolescents at least 25 kg
Routine four-hour HD or peritoneal dialysis requires no additional dose. Use the HIV product's renal table, not the HBV product regimen.
HIV treatment for adults and adolescents at least 25 kg
CrCl (mL/min)
First dose
Maintenance
>=50
Standard regimen
150 mg twice daily or 300 mg daily
30-49
150 mg
150 mg daily
15-29
150 mg
100 mg daily
5-14
150 mg
50 mg daily
<5
50 mg
25 mg daily
Read the retained text before reformatting
For HIV treatment in adults and adolescents at least 25 kg, reduce lamivudine dosing below CrCl 50 mL/min. At 30-49 mL/min give 150 mg daily; lower bands have distinct first and maintenance doses. Routine four-hour HD or peritoneal dialysis requires no additional dose. Use the HIV product's renal table, not the HBV product regimen.
This reference does not select a regimen. Complete the indication, measured/estimated renal function and trend, dialysis setting, source rationale, monitoring and reassessment plan in your institution's approved documentation system. Confirm the complete current source before adopting its regimen.
GlobalRPh Renal Dosing Master v7.4. Review the retrieval and revision dates attached to each source. Selecting a reference does not imply clinical verification.
