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Clinical context remains essential
Independent clinical review is pending. Confirm indication, exact formulation/route, population, renal measure and units, kidney-function stability, dialysis prescription, interacting drugs, monitoring and source revision. An RX mirror and its original label are not independent corroboration. Missing disagreement notes do not certify agreement.
High-priority source disagreement: the old handbook supplies small doses in severe renal disease, while the later toxicity recommendation advises avoidance. No patient-specific safe dose is calculated.
Check source scope before reading a dose
Renal Drug Handbook, fifth edition - Baclofen oral immediate-release tablets
Product / population
Historical renal/RRT cross-check for the named ingredient; not a current U.S. prescribing instruction.
Renal method
Book table headings say GFR (mL/min); the preface states adjustment information is based on Cockcroft-Gault CrCl, not indexed eGFR. Do not substitute methods.
Source revision
Fifth edition, 2019
Retrieved
2026-09-05
Local review status
Historical source, separately displayed. Renal tables were read with page-image inspection.
Documented differences and cautions on this drug
All record notes are retained here, including notes about sources not selected in this review.
Older-adult avoidance guidance is more conservative than a generic reduction instruction
AGS 2023 recommends avoidance in older adults below its eGFR threshold, whereas the product-label summary advises caution and possible reduction.
What to reconcile: Review the age-specific source before using a reduced-dose schedule. The geriatric warning is not an intrathecal dosing rule.
Renal Drug Handbook, fifth edition - Baclofen oral immediate-release tablets
UK Renal Pharmacy Group / CRC Press · Historical renal/RRT cross-check for the named ingredient; not a current U.S. prescribing instruction.
Renal method: Book table headings say GFR (mL/min); the preface states adjustment information is based on Cockcroft-Gault CrCl, not indexed eGFR. Do not substitute methods. Source date: Fifth edition, 2019 Retrieved: 2026-09-05
Historical source, separately displayed. Renal tables were read with page-image inspection.
Historical renal and dialysis observations
The historical table proposes 5 mg three times daily at 20-50 mL/min, twice daily at 10-20 and daily below 10. The following page documents encephalopathy and major toxicity in dialysis patients after small doses.
RDM31-baclofen-oral-book · Source locator: Dose in renal impairment; renal replacement therapies; Other information
Source-specific limits
SAFETY DISAGREEMENT: these historical doses must not be read as established safe regimens. The separate Wolf et al. recommendation advises avoidance below eGFR 30 mL/min/1.73 m2 or during renal replacement therapy.
Source identity and provenance
Retrieved
2026-09-05
Handbook page
Printed page(s) 107-108; PDF page(s) 126,127
Renal-function method
Book table headings say GFR (mL/min); the preface states adjustment information is based on Cockcroft-Gault CrCl, not indexed eGFR. Do not substitute methods.
This reference does not select a regimen. Complete the indication, measured/estimated renal function and trend, dialysis setting, source rationale, monitoring and reassessment plan in your institution's approved documentation system. Confirm the complete current source before adopting its regimen.
GlobalRPh v6.6 | RDM66-DIRECT-PHP-20260911 | Local library date 2026-09-11. Selected-card identity does not imply clinical verification.