GlobalRPh Renal Dosing Masterv6.6
Source review / handoff

Capecitabine

One or two intact local summaries. No averaged regimen, patient-specific dose or automatic source preference.

Selecting here opens the current stored cards. The pinned link below records their fingerprints. Do not enter patient information in links or searches.

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1 local source card selected. Local card fingerprints checked where supplied. This is not an original-document hash, source-currency guarantee or clinical approval. Record-level cautions below are the current library's cautions, not a frozen prior version.

Copy is optional; the link can be selected and copied manually. No patient data or dose decision is collected.

Clinical context remains essential

Independent clinical review is pending. Confirm indication, exact formulation/route, population, renal measure and units, kidney-function stability, dialysis prescription, interacting drugs, monitoring and source revision. An RX mirror and its original label are not independent corroboration. Missing disagreement notes do not certify agreement.

The original renal band is printed as >51-80 and the reduced dose as 950 mg/m2. These values are preserved as source text, not recalculated or silently corrected.

Check source scope before reading a dose

GlobalRPh RX List - capecitabine tablets

Product / population
Oral capecitabine: renal adjustment must be applied to the correct indication-specific regimen; DPYD/DPD and toxicity requirements remain separate.
Renal method
Cockcroft-Gault CrCl, mL/min
Source revision
Source revision date not established in selected retrieval.
Retrieved
2026-09-10
Local review status
Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph.

Documented differences and cautions on this drug

All record notes are retained here, including notes about sources not selected in this review.

eviQ protocols disagree at the same indexed eGFR band

At eGFR 45-59 mL/min/1.73 m2, metastatic colorectal protocol 94 considers a 25% reduction or an alternative, whereas post-neoadjuvant breast protocol 3503 permits full dose with increased adverse-event risk. Protocol 94 explicitly identifies a committee-endorsed departure from ADDIKD.

What to reconcile: Choose by the exact cancer setting and protocol, not whichever dose is larger or smaller. These are two protocols from one organization, not independent confirmation. Record the indication, protocol number, renal metric and oncology rationale.

Source-specific interpretation; independent clinician adjudication pending.

Open this note and its source references

A label CrCl band is not an eGFR band

The newly imported RX label specifies Cockcroft-Gault CrCl; the eviQ tables use indexed eGFR. Similar numbers do not establish equivalent renal categories. The newer RX text says a dose below CrCl 30 is not established, unlike the older preserved source restriction.

What to reconcile: Read the original and newer source in full. Do not convert a missing established dose into permission to use a regimen or substitute eGFR for CrCl without reconciling the method. A retrieval date alone does not establish a label version.

Source-specific interpretation; independent clinician adjudication pending.

Open this note and its source references

Current label renal wording and DPYD testing need a dated reading

The retrieved 2026 official labels state that a dosage below Cockcroft-Gault CrCl 30 is not established, whereas the older generic RX mirror calls this range contraindicated. Current labels also include pretreatment DPYD testing precautions.

What to reconcile: Use the exact current product label and oncology protocol; do not interpret absence of an established dose as permission. Older eviQ comparisons were not rechecked in this pass.

Source-specific interpretation; independent clinician adjudication pending.

Open this note and its source references
Rxlist

GlobalRPh RX List - capecitabine tablets

Open original reference

GlobalRPh-hosted RX List · Oral capecitabine: renal adjustment must be applied to the correct indication-specific regimen; DPYD/DPD and toxicity requirements remain separate.

Renal method: Cockcroft-Gault CrCl, mL/min
Source date: Source revision date not established in selected retrieval.
Retrieved: 2026-09-10

Label mirror, not independent corroboration. This is selected locally stored RX List content. Full monograph import and current official-label review are not implied.
Historical product / current restriction. Historical renal instructions do not establish current prescribing eligibility. Read the regulatory caution.

Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph.

Renal dosing, restrictions and evidence limits

This generic-tablet mirror states that severe impairment below Cockcroft-Gault CrCl 30 mL/min is a contraindication. Its dose section uses a 25% starting-dose reduction at CrCl 30-50. This is retained as source-specific wording, not silently substituted for current selected official labeling.

The separately retrieved 2026 official labels say a dose below 30 has not been established. These statements must remain attributed rather than averaged or converted into an invented severe-renal regimen.

RDM57-rxlist-capecitabine-64ae450f60-C1 · Source locator: Dose adjustments in special populations; Contraindications: Severe Renal Impairment

Source-specific limits

Selected sections only; not a complete prescribing monograph or independent clinician approval.

The hosted label mirror is not independent corroboration of its underlying label. Official-label confirmation of this new card remains pending unless a separate official card is shown.

Source identity and provenance
Source family
product_label_mirror
Source
https://globalrph.com/rx-list/capecitabine-tablets-drug/
Retrieved
2026-09-10
Renal-function method
Cockcroft-Gault CrCl, mL/min
Source date/version
Source revision date not established in selected retrieval.
Hash meaning
SHA-256 of local authored summary only; not original HTML, PDF or SPL bytes.
Local summary SHA-256
02224b0ed0cc3539d716f03550442895a205c1bc00f50dd2ac43d421722a46e9

Document the clinical decision separately

This reference does not select a regimen. Complete the indication, measured/estimated renal function and trend, dialysis setting, source rationale, monitoring and reassessment plan in your institution's approved documentation system. Confirm the complete current source before adopting its regimen.

GlobalRPh v6.6 | RDM66-DIRECT-PHP-20260911 | Local library date 2026-09-11. Selected-card identity does not imply clinical verification.

Pinned reference: https://globalrph.com/blogCalcs/renal-dosing-master/compare.php?id=capecitabine&s1=RDM57-rxlist-capecitabine-64ae450f60&h1=8e3cee444991604ed4a4c10ca3570c854f642c68a7a7d346f42daf8a84ea1152