GlobalRPh Renal Dosing Masterv7.4
Renal Dosing Master: fast drug lookup
Source review / handoff

Modafinil (Provigil), oral tablet

One or two intact local summaries. No averaged regimen, patient-specific dose or automatic source preference.

Selecting here opens the current stored cards. The pinned link below records their fingerprints. Do not enter patient information in links or searches.

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1 local source card selected. Local card fingerprints checked where supplied. This is not an original-document hash, source-currency guarantee or clinical approval. Record-level cautions below are the current library's cautions, not a frozen prior version.

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Clinical context remains essential

Independent clinical review is pending. Confirm indication, exact formulation/route, population, renal measure and units, kidney-function stability, dialysis prescription, interacting drugs, monitoring and source revision. An RX mirror and its original label are not independent corroboration. Missing disagreement notes do not certify agreement.

Check source scope before reading a dose

Provigil - labeled renal guidance

Product / population
Modafinil (Provigil), oral tablet
Renal method
Creatinine clearance (CrCl), mL/min
Source revision
DailyMed SPL version 2, posted Dec 10, 2025
Retrieved
2026-11-07
Local review status
Selected renal passages reviewed; independent clinician adjudication pending.

Documented differences and cautions on this drug

All record notes are retained here, including notes about sources not selected in this review.

Provigil - product and source limitations

This study did not establish a dialysis schedule or a numeric dose reduction.

What to reconcile: Apply only to the stated formulation, indication and renal population.

Selected renal passages reviewed; independent clinician adjudication pending.

Open this note and its source references
Official

Provigil - labeled renal guidance

Open original reference

DailyMed / product prescribing information · Modafinil (Provigil), oral tablet

Renal method: Creatinine clearance (CrCl), mL/min
Source date: DailyMed SPL version 2, posted Dec 10, 2025
Retrieved: 2026-11-07

Pharmacokinetic observation only. A drug-exposure observation is not itself a dose recommendation.

Selected renal passages reviewed; independent clinician adjudication pending.

Renal guidance: 12.3 Pharmacokinetics

At CrCl 20 mL/min or lower, a single-dose study found little change in parent modafinil disposition but about ninefold higher exposure to inactive modafinil acid. This study did not establish a dialysis schedule or a numeric dose reduction.

RDM74-provigil-official-1 · Source locator: Renal guidance: 12.3 Pharmacokinetics

Source identity and provenance
Source family
product_label
Source
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=3b8d1c32-dac9-50e6-e063-6394a90aa5a5
Retrieved
2026-11-07
Renal-function method
Creatinine clearance (CrCl), mL/min
Source date/version
DailyMed SPL version 2, posted Dec 10, 2025
Hash meaning
SHA-256 of the local selected-source summary
Local summary SHA-256
2b70a8098c66e3b74a898cb08daaf1325321fd2c4d79e34eea4802ab643c3e26

Document the clinical decision separately

This reference does not select a regimen. Complete the indication, measured/estimated renal function and trend, dialysis setting, source rationale, monitoring and reassessment plan in your institution's approved documentation system. Confirm the complete current source before adopting its regimen.

GlobalRPh Renal Dosing Master v7.4. Review the retrieval and revision dates attached to each source. Selecting a reference does not imply clinical verification.

Pinned reference: https://globalrph.com/blogCalcs/renal-dosing-master/compare.php?id=rx-provigil&s1=RDM74-provigil-official&h1=89d2ffb810ff13663f9c0aa2ac8448e9a20439bd8b22a1206325bd44dcd76de8

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