One or two intact local summaries. No averaged regimen, patient-specific dose or automatic source preference.
1 local source card selected. Local card fingerprints checked where supplied. This is not an original-document hash, source-currency guarantee or clinical approval. Record-level cautions below are the current library's cautions, not a frozen prior version.
Independent clinical review is pending. Confirm indication, exact formulation/route, population, renal measure and units, kidney-function stability, dialysis prescription, interacting drugs, monitoring and source revision. An RX mirror and its original label are not independent corroboration. Missing disagreement notes do not certify agreement.
The source uses indexed renal thresholds but prints an unindexed Cockcroft-Gault formula; preserve the distinction rather than silently treating the units as equivalent.
The label mirror uses a daily renal regimen with a timing-dependent post-HD supplement. UCSF also offers a selected post-HD-only strategy, with toxicity, age and low-weight qualifications. The source renal units and exactly-30 boundary do not align automatically.
What to reconcile: Use one complete protocol with the dialysis prescription and ID/pharmacy review. Do not add the label supplement to an institutional post-HD dose or silently equate indexed and unindexed clearance.
Open this note and its source referencesThe label mirror says a supplement is needed within six hours but not needed when the dose is at least six hours before dialysis. The boundary is overlapping as printed.
What to reconcile: Clarify the timing endpoint with the controlling product label and dialysis pharmacist. Do not round an administration time to decide which instruction applies.
Open this note and its source referencesAge >=13 years: 1 g once daily. Age 3 months to 12 years: 15 mg/kg twice daily, maximum 1 g/day. May administer IV for up to 14 days or IM for up to 7 days; IV infusion over 30 minutes. IM is an alternative where appropriate. DO NOT MIX OR CO-INFUSE WITH OTHER MEDICATIONS. DO NOT USE DEXTROSE DILUENTS.
Source treatment guidelines for normal renal function (CrCl >90 mL/min/1.73 m2) and body weight use these age-specific doses:
| Indication | Total antimicrobial duration |
|---|---|
| Complicated intra-abdominal | 5 to 14 days |
| Complicated skin/skin structure including diabetic foot | 7 to 14 days; adult diabetic-foot patients in source received up to 28 days parenteral or parenteral plus oral switch |
| Community-acquired pneumonia | 10 to 14 days |
| Complicated urinary tract including pyelonephritis | 10 to 14 days |
| Acute pelvic infection including postpartum endomyometritis, septic abortion, postoperative gynecologic | 3 to 10 days |
Pneumonia/UTI durations can include oral stepdown after at least 3 days of parenteral therapy and demonstrated improvement.
Elective colorectal surgery prophylaxis in adults: 1 g IV once 1 hour before incision.
GRPH-ertapenem-01 · Source locator: Usual Dosing (Adults)
Adults: CrCl >30 mL/min/1.73 m2, no adjustment. CrCl <=30, including ESRD <=10: 500 mg daily. No pediatric renal-insufficiency data.
GRPH-ertapenem-02 · Source locator: Renal Dosing
If the adult daily 500 mg dose is administered within 6 hours before HD, give an additional 150 mg after HD. If given at least 6 hours before HD, no supplement is needed. No data for peritoneal dialysis, hemofiltration, or pediatric HD.
When only serum creatinine is available, use a steady-state value. Source formula: male CrCl = weight (kg) x (140 - age in years) / [72 x serum creatinine (mg/100 mL)]; female result = male result x 0.85.
GRPH-ertapenem-03 · Source locator: Hemodialysis
The source uses indexed renal thresholds but prints an unindexed Cockcroft-Gault formula; preserve the distinction rather than silently treating the units as equivalent.
This reference does not select a regimen. Complete the indication, measured/estimated renal function and trend, dialysis setting, source rationale, monitoring and reassessment plan in your institution's approved documentation system. Confirm the complete current source before adopting its regimen.
Pinned reference: https://globalrph.com/blogCalcs/renal-dosing-master/compare.php?id=ertapenem&s1=original&h1=8381a92c28adce791bdaeaa60e517d5dccbd4a45452c80b7751a1d3e63609ab5