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Hycamtin capsules - labeled renal guidance
Product / population
Topotecan (Hycamtin), adult oral capsules for relapsed small cell lung cancer
Renal method
Cockcroft-Gault CrCl using ideal body weight, mL/min
Source revision
DailyMed SPL version 1, effective 2023-09-18; posted Oct 31, 2024
All record notes are retained here, including notes about sources not selected in this review.
Hycamtin capsules - product and source limitations
The primary label table includes 49 mL/min in the 30-49 band; section 8.6 also uses the words less than 49. At this boundary verify section 2.3 of the exact capsule label.
What to reconcile: The primary label table includes 49 mL/min in the 30-49 band; section 8.6 also uses the words less than 49. At this boundary verify section 2.3 of the exact capsule label.
Use the oral dose-modification table. Verify blood-count recovery before the next cycle. IV topotecan uses different doses.
Adult renal dosing in this source
Cockcroft-Gault CrCl (mL/min), ideal body weight
Oral starting dose on days 1-5 of each 21-day cycle
30-49
1.5 mg/m2/day
<30
0.6 mg/m2/day
Read the retained text before reformatting
Use Cockcroft-Gault with ideal body weight. At CrCl 30-49 mL/min, give 1.5 mg/m2/day; below 30, give 0.6 mg/m2/day. Both are on days 1-5 of the 21-day oral cycle. Use the oral dose-modification table. Verify blood-count recovery before the next cycle. IV topotecan uses different doses.
RDM73-hycamtin-capsules-official-1 · Source locator: Renal guidance: 2.1, 2.3 and 8.6
This reference does not select a regimen. Complete the indication, measured/estimated renal function and trend, dialysis setting, source rationale, monitoring and reassessment plan in your institution's approved documentation system. Confirm the complete current source before adopting its regimen.
GlobalRPh Renal Dosing Master v7.4. Review the retrieval and revision dates attached to each source. Selecting a reference does not imply clinical verification.
