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Clinical context remains essential
Independent clinical review is pending. Confirm indication, exact formulation/route, population, renal measure and units, kidney-function stability, dialysis prescription, interacting drugs, monitoring and source revision. An RX mirror and its original label are not independent corroboration. Missing disagreement notes do not certify agreement.
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GOCOVRI: MDRD method despite a creatinine-clearance heading
The label expressly uses MDRD and indexed units. The immediate-release amantadine record has different product-specific schedules; a numerically similar renal value is not proof of equivalence.
What to reconcile: Verify renal method and formulation before selecting the nightly extended-release regimen. Do not transfer an immediate-release schedule or dialysis dose.
The label uses an MDRD-derived value in mL/min/1.73 m2 although it calls it creatinine clearance. Do not substitute an unindexed Cockcroft-Gault value.
What to reconcile: Apply only to the stated formulation, indication and renal population.
At 60-89, start 137 mg at bedtime and increase after one week to 274 mg. At 30-59, start 68.5 mg at bedtime and, if needed after one week, increase to 137 mg. At 15-29, use 68.5 mg at bedtime. Below 15, use is contraindicated. The label uses an MDRD-derived value in mL/min/1.73 m2 although it calls it creatinine clearance. Do not substitute an unindexed Cockcroft-Gault value.
RDM73-gocovri-official-1 · Source locator: Renal guidance: 2.3, 4 and 8.6
This reference does not select a regimen. Complete the indication, measured/estimated renal function and trend, dialysis setting, source rationale, monitoring and reassessment plan in your institution's approved documentation system. Confirm the complete current source before adopting its regimen.
GlobalRPh Renal Dosing Master v7.4. Review the retrieval and revision dates attached to each source. Selecting a reference does not imply clinical verification.
