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1 local source card selected. Local card fingerprints checked where supplied. This is not an original-document hash, source-currency guarantee or clinical approval. Record-level cautions below are the current library's cautions, not a frozen prior version.
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Clinical context remains essential
Independent clinical review is pending. Confirm indication, exact formulation/route, population, renal measure and units, kidney-function stability, dialysis prescription, interacting drugs, monitoring and source revision. An RX mirror and its original label are not independent corroboration. Missing disagreement notes do not certify agreement.
The original fixed-combination renal cutoff is retained for explicit comparison with current labeling.
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GlobalRPh RX List - EPZICOM
Product / population
EPZICOM fixed-dose HIV-treatment tablet; not individually adjustable lamivudine.
Renal method
Estimated creatinine clearance (CrCl), mL/min. The selected subsection does not independently establish an estimating equation.
Source revision
Source revision date not established in selected retrieval.
Retrieved
2026-09-08
Local review status
Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph.
Documented differences and cautions on this drug
All record notes are retained here, including notes about sources not selected in this review.
EPZICOM: label restriction versus limited-evidence panel practice
The selected label does not recommend the fixed-dose combination below CrCl 30. NIH describes some panel members retaining full-dose lamivudine there but explicitly states that evidence is insufficient.
What to reconcile: Preserve the evidence qualification and obtain HIV-specialist or institutional adjudication. Do not present that exception as a new label-approved dose.
GlobalRPh-hosted RX List · EPZICOM fixed-dose HIV-treatment tablet; not individually adjustable lamivudine.
Renal method: Estimated creatinine clearance (CrCl), mL/min. The selected subsection does not independently establish an estimating equation. Source date: Source revision date not established in selected retrieval. Retrieved: 2026-09-08
Label mirror, not independent corroboration. This is selected locally stored RX List content. Full monograph import and current official-label review are not implied.
Restriction or avoidance guidance. Read the specific threshold, age, formulation and dialysis exclusions; do not generalize across products.
Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph.
Renal dosing, restrictions and evidence limits
The selected RX labeling does not recommend EPZICOM at CrCl <30 mL/min. When lamivudine needs a renal reduction, use individual components rather than an invented fraction or interval for the fixed-dose tablet. This is distinct from the separately stored NIH discussion of selected clinicians continuing full-dose lamivudine despite limited evidence.
RDM45-rxlist-epzicom-10391176cb-C1 · Source locator: Use in Specific Populations: Renal Impairment, lines 339-341.
This reference does not select a regimen. Complete the indication, measured/estimated renal function and trend, dialysis setting, source rationale, monitoring and reassessment plan in your institution's approved documentation system. Confirm the complete current source before adopting its regimen.
GlobalRPh v6.6 | RDM66-DIRECT-PHP-20260911 | Local library date 2026-09-11. Selected-card identity does not imply clinical verification.