GlobalRPh Renal Dosing Masterv6.6
Source review / handoff

Penicillin G

One or two intact local summaries. No averaged regimen, patient-specific dose or automatic source preference.

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1 local source card selected. Local card fingerprints checked where supplied. This is not an original-document hash, source-currency guarantee or clinical approval. Record-level cautions below are the current library's cautions, not a frozen prior version.

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Clinical context remains essential

Independent clinical review is pending. Confirm indication, exact formulation/route, population, renal measure and units, kidney-function stability, dialysis prescription, interacting drugs, monitoring and source revision. An RX mirror and its original label are not independent corroboration. Missing disagreement notes do not certify agreement.

Historical indication-specific regimens are preserved. Penicillin G potassium, benzathine penicillin G and oral penicillin VK are not interchangeable formulations.

Check source scope before reading a dose

Penicillin G potassium - aqueous IV, UCSF renal tables

Product / population
Adults; aqueous IV potassium salt. Selected serious-infection rows, not depot products.
Renal method
Creatinine clearance, mL/min
Source revision
Revision not established in selected retrieval
Retrieved
2026-09-10
Local review status
Selected source sections stored locally. Not a complete monograph or independent clinical approval.

Documented differences and cautions on this drug

All record notes are retained here, including notes about sources not selected in this review.

Before use: Penicillin G

Selected serious-infection rows agree with the retained UCSF summary; source-specific doses remain separate from other evidence.

What to reconcile: Choose the indication, potassium/sodium formulation and dialysis setting; do not use these schedules for benzathine or procaine penicillin.

Source-specific interpretation; independent clinician adjudication pending.

Open this note and its source references
Professional

Penicillin G potassium - aqueous IV, UCSF renal tables

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UCSF Infectious Diseases Management Program · Adults; aqueous IV potassium salt. Selected serious-infection rows, not depot products.

Renal method: Creatinine clearance, mL/min
Source date: Revision not established in selected retrieval
Retrieved: 2026-09-10

Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.
Before using this finding

Choose the indication, potassium/sodium formulation and dialysis setting; do not use these schedules for benzathine or procaine penicillin.

Dialysis evidence: A regimen is reported in selected content

Selected source sections stored locally. Not a complete monograph or independent clinical approval.

Renal guidance and important limits

Limits that apply to these rows

Assess potassium load; sodium penicillin G may be preferable when available. Do not transfer to benzathine or procaine products.

Neurosyphilis, meningitis, necrotizing skin infection or toxic shock - IV
CrCl, mL/minSource-specific dose / instruction
>504 million units every 4 hours
10-503 million units every 4 hours
<103 million units every 6 hours
Endovascular infection or bacteremia - IV
CrCl, mL/minSource-specific dose / instruction
>503 million units every 4 hours
10-503 million units every 6 hours
<102 million units every 6 hours
Dialysis guidance - separate source-specific schedules
Penicillin G potassium IV - dialysis
Dialysis setting / indicationSource-specific schedule
Intermittent HD - neurosyphilis/meningitis/necrotizing infection/toxic shock4 million units once, then 2 million units every 4 hours
Continuous HD - same indications3 million units every 4 hours
Intermittent HD - endovascular infection/bacteremia3 million units once, then 2 million units every 6 hours
Continuous HD - endovascular infection/bacteremia3 million units every 6 hours
Read the retained text before reformatting

Neurosyphilis, meningitis, necrotizing skin infection or toxic shock - IV

CrCl, mL/minSource-specific dose / instruction
>504 million units every 4 hours
10-503 million units every 4 hours
<103 million units every 6 hours

Endovascular infection or bacteremia - IV

CrCl, mL/minSource-specific dose / instruction
>503 million units every 4 hours
10-503 million units every 6 hours
<102 million units every 6 hours

Penicillin G potassium IV - dialysis

Dialysis setting / indicationSource-specific schedule
Intermittent HD - neurosyphilis/meningitis/necrotizing infection/toxic shock4 million units once, then 2 million units every 4 hours
Continuous HD - same indications3 million units every 4 hours
Intermittent HD - endovascular infection/bacteremia3 million units once, then 2 million units every 6 hours
Continuous HD - endovascular infection/bacteremia3 million units every 6 hours

Assess potassium load; sodium penicillin G may be preferable when available. Do not transfer to benzathine or procaine products.

RDM63-professional-penicillin-g-7ad94b974d-C1 · Source locator: Non-dialysis and intermittent/continuous hemodialysis tables; selected serious-infection indications

Source-specific limits

Assess potassium load; sodium penicillin G may be preferable when available. Do not transfer to benzathine or procaine products.

Source identity and provenance
Source family
professional_guidance
Source
https://idmp.ucsf.edu/content/penicillin-g-potassium-aqueous-iv
Retrieved
2026-09-10
Renal-function method
Creatinine clearance, mL/min
Source date/version
Revision not established in selected retrieval
Hash meaning
Local authored summary, not source HTML/XML/PDF bytes
Local summary SHA-256
f17431300215ffeff11a785b2b911f255453ab39176449e439bfb2002981492f

Document the clinical decision separately

This reference does not select a regimen. Complete the indication, measured/estimated renal function and trend, dialysis setting, source rationale, monitoring and reassessment plan in your institution's approved documentation system. Confirm the complete current source before adopting its regimen.

GlobalRPh v6.6 | RDM66-DIRECT-PHP-20260911 | Local library date 2026-09-11. Selected-card identity does not imply clinical verification.

Pinned reference: https://globalrph.com/blogCalcs/renal-dosing-master/compare.php?id=penicillin-g&s1=RDM63-professional-penicillin-g-7ad94b974d&h1=641958461edbb238b4481581762b7ddc01127468f4fefb21d981998a3db5ea38