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Clinical context remains essential
Independent clinical review is pending. Confirm indication, exact formulation/route, population, renal measure and units, kidney-function stability, dialysis prescription, interacting drugs, monitoring and source revision. An RX mirror and its original label are not independent corroboration. Missing disagreement notes do not certify agreement.
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Cubicin - labeled renal guidance
Product / population
Daptomycin (Cubicin), adult IV treatment of cSSSI or S. aureus bacteremia
Renal method
Creatinine clearance (CrCl), mL/min; use the product-specific calculation
All record notes are retained here, including notes about sources not selected in this review.
Do not merge label and higher-dose institutional dialysis protocols
The label includes CrCl exactly 30 in its >=30 band. UCSF prints >30 and <30, omitting exactly 30, and uses higher doses and different HD scheduling.
What to reconcile: Keep source-specific dose, interval, indication, weight basis and modality together. The official threshold is explicit; seek institutional clarification rather than silently changing its headings.
The labeled adult doses for cSSSI and S. aureus bacteremia differ from UCSF institutional high-dose regimens. Check infection, weight convention and dialysis modality.
What to reconcile: The labeled adult doses for cSSSI and S. aureus bacteremia differ from UCSF institutional high-dose regimens. Check infection, weight convention and dialysis modality.
Renal guidance: 2, renal dosing and 5, CPK monitoring
For adult CrCl <30 mL/min, use 4 mg/kg IV every 48 hours for complicated skin/skin-structure infection or 6 mg/kg every 48 hours for S. aureus bloodstream infection. The interval is every 24 hours at CrCl >=30. The 48-hour schedule includes HD and CAPD. On HD days, dose after dialysis when possible. Check renal function and CPK more often than weekly in renal impairment.
This reference does not select a regimen. Complete the indication, measured/estimated renal function and trend, dialysis setting, source rationale, monitoring and reassessment plan in your institution's approved documentation system. Confirm the complete current source before adopting its regimen.
GlobalRPh Renal Dosing Master v7.4. Review the retrieval and revision dates attached to each source. Selecting a reference does not imply clinical verification.
